Abstract
The development of radiotherapy in the management of brain tumours has been largely empirical, but since its introduction it has developed into one of the most effective treatment modalities in the management of patients with intracranial tumours. In some rare malignant brain tumours such as germinoma, radiotherapy is curative. The excellent disease control following conservative surgery and radiotherapy in the more benign tumours such as optic nerve glioma, pituitary adenoma and craniopharyngioma has established radiotherapy as the essential component of treatment. In highgrade gliomas, the commonest of malignant brain tumours, radiotherapy achieves prolongation of disease-free survival and survival. The value of radiotherapy has been demonstrated in prospective randomized studies in high-grade gliomas. In other brain tumours the role of radiotherapy is not proven beyond doubt and we have to rely for proof of its effectiveness on selected series of patients referred for radiotherapy largely following incomplete tumour excision.
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References
Alexander E III, Loeffler JS (1992) Radiosurgery using a modified linear accelerator. Neurosurg Clin N Am 3: 167–190
Allen JC, Kim JH, Packer RJ (1987) Neoadjuvant chemotheraphy for newly diagnosed germ-cell tumours of the central nervous system. J Neurosurg 67: 65–70
Aug KK, Jiang GL, Guttenberg R et al. (1992) Impact of spinal cord repair kinetics on the practice of altered fractionation schedules. Radiother Oncol 25: 287–294
Barbaro NM, Gutin PH, Wilson CB et al. (1987) Radiation therapy in the treatment of partially resected meningiomas. Neurosurgery 20: 525–528
Barnard RO, Geddes JF (1987) The incidence of multifocal cerebral gliomas. A histologic study of large hemisphere sections. Cancer 60: 1519–1531
Berry MP, Jenkin DT, Keen CW, Nair BD, Simpson WJ (1981) Radiation treatment for medulloblastoma. A 21 year review. J Neurosurg 55: 43–51
Berry MP, Simpson WJ (1981) Radiation therapy is the management of primary malignant lymphoma of the brain. Int J Rad Oncol Biol Phys 7: 55–59
Bleehen NM, Stenning SP (1991) A Medical Research Council trial of two radiotherapy doses in the treatment of grades 3 and 4 astrocytoma. Br J Cancer 64: 769–774
Bleyer WA (1981) Neurologic sequelae of methotrexate and ionising radiation: A new classification. Cancer Treat Rep 65: 89–98
Bloom HJG (1982) Intracranial tumors: response and resistance to therapeutic endeavours, 1970–1980. Int J Radiat Oncol Biol Phys 8: 1083–1113
Bloom HJG (1983) Primary intracranial germ cell tumours. Clin Oncol 2: 233–257
Bloom HJG (1986) Tumours of the central nervous system. In: Voute PA, Barret A, Bloom HJG, Lemerle J, Neidardt MK (eds) Cancer in Children — Clinical Management. Springer-Verlag, Berlin, pp 197–222
Bloom HJG, Bessel EM (1990) Medulloblastoma in adults: a review of 97 patients treated between 1956 and 1981. Int J Radiat Oncol Biol Phys 18: 763–773
Boden G (1948) Radiation myelitis of the cervical spinal cord. Br J Radiol 21: 464–469
Borgelt B, Gelber R, Kramer S et al. (1980) The palliation of brain metastases: final results of the first two studies by the Radiation Therapy Oncology Group. Int J Radiol Oncol Biol Phys 6: 1–9
Brada M, Dearnley D, Horwich A, Bloom HJG (1990) Management of primary cerebral lymphoma with initial chemotherapy: preliminary results and comparison with patients treated with radiotherapy alone. Int J Radiol Oncol Biol Phys 18(4): 787–792
Brada M, Rajan B (1990) Spinal seeding in cranial germinoma. Br J Cancer 61: 339–340
Bullard DE, Rawlings CE, Phillips B et al. (1987) Oligodendroglioma. An analysis of the value of radiation therapy. Cancer 60: 2179–2188
Burger PC, Vogel FS (eds) (1982) Surgical Pathology of the Nervous System and Its Coverings. John Wiley, New York
Burger PC, Rawlings CE, Cox EB et al. (1987) Clinicopathologic correlations in the oligodendroglioma. Cancer 59: 1345–1352
Burger PC, Hemz ER, Shibata T et al. (1988) Topographic anatomy and CT correlations in the untreated glioblastoma multiforme. J Neurosurg 68: 698
Cairncross J, Macdonald DR, Ramsay DA (1992) Aggressive oligodendroglioma: a chemosensitive tumour. Neurosurgery 31(1): 78–81
Carella RJ, Gelber R, Hendrickson F et al. (1980) Value of radiation therapy in the management of patients with cerebral metastases from malignant melonoma. Radiation Therapy Oncology Group Brain Metastases Study I and II. Cancer 45: 679–683
Catterall M, Bloom HJG, Ash DV et al. (1980) Fast neutrons compared with megavoltage x-rays in the treatment of patients with supratentorial glioblastoma: a controlled pilot study. Int J Radiat Oncol Biol Phys 6: 261
Chadwick KH, Leenhouts HP (1973) A molecular theory of cell survival. Phys Med Biol 18: 78–87
Chan RC, Thompson GB (1984) Morbidity, mortality and quality of life following surgery for intracranial meningiomas — a retrospective study in 257 cases. J Neurosurg 60: 52–60
Chang CH (1977) Hyperbaric oxygen and radiation therapy in the management of glioblastoma. In Modern Concepts in Brain Tumour Therapy: Laboratory and Clinical Investigations. National Cancer Institute Monograph No. 46. US Govt Printing Office, Washington DC, p 163
Chang CH, Horton J, Schoenfeld D et al. (1983) Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. Cancer 52: 997
Chen GTY (1988) Dose volume histograms in treatment planning. Int J Radiat Oncol Biol Phys 14: 1319–1320
Choucair Ak, Levin VA, Gutin PH et al. (1986) Development of multiple lesions during radiation therapy and chemotherapy in patients with gliomas. J Neurosurg 65: 654
Colombo F, Benedetti A, Pozza F et al. (1985) External stereotactic irradiation by linear accelerator. Neurosurgery 16: 154
DeAngelis LM, Yahalom J, Thaler HT et al. (1992) Combined modality therapy for primary CNS lymphoma. J Clin Oncol 10(4): 635–643
Dearnaley DP, A’Hearn R, Whitaker S et al. (1990) Pineal and CNS germ cell tumours: Royal Marsden Hospital experience 1962–1987. Int J Radiat Oncol Biol Phys 18(4): 7773–7781
Diener-West M, Dobbins TW, Phillips TL et al. (1989) Identification of an optimal subgroup for treatment evaluation of patients with brain metastases using RTOG study 7916. Int J Radiat Oncol Biol Phys 16: 669–673
Disclafani A, Hudgins RJ, Edwards MSB et al. (1989) Pineocytomas. Cancer 63: 302–304
Douglas BG, Worth AJ (1982) Superfractionation in glioblastoma multiforme — results of a phase II study. Int J Radiat Oncol Biol Phys 8: 1787
Duffner PK, Cohen ME, Thomas PRM et al. (1985) The long-term effects of cranial irradiation on the central nervous system. Cancer 56: 1841–1846
Duncan W, McLelland J, Jack WJL et al. (1986) Report of a randomised pilot study of the treatment of patients with supratentorial gliomas using neuron irradiation. Br J Radiol 59: 373
Eby M, Grufferman S, Flannelly CM et al. (1988) Increasing incidence of primary brain lymphoma in the US. Cancer 62: 2461–2465
Emami B, Lyman J, Brown A et al. (1991) Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21: 109–122
Engenhart R, Kimmig BN, Höver KH (1990) Stereotactic single high dose radiation therapy of benign intracranial meningiomas. Int J Radiat Oncol Biol Phys 19(4): 1021–1026
Fazekas JT (1977) Treatment of grades I and II brain astrocytomas. The role of radiotherapy. Int J Radiat Oncol Biol Phys 2: 661–666
Flickinger JC, Tarres C, Deutsch M (1988) Management of low-grade gliomas of the optic nerve and chiasm. Cancer 61: 635–642
Florell RC, Macdonald DR, Irish WD et al. (1992) Selection bias, survival, and brachytherapy for glioma. J Neurosurg 76: 179–183
Fowler JF (1985) In: Proc XVI Int Conf Radiology, Hawaii, pp 201–206
Fulton DS, Urtasun RC, Shin KH et al. (1984) Misonidazole combined with hyperfractionation in the management of malignant glioma. Int J Radiat Oncol Biol Phys 10: 1709
Gelber RD, Larson M, Borgelt BB et al. (1981) Equivalence of radiation schedules for the palliative treatment of brain metastases in patients with favorable prognosis. Cancer 48: 1749–1753
Glaholm J, Bloom HJG, Crow JH (1990) The role of radiotherapy in the management of intracranial meningiomas: The Royal Marsden Hospital experience with 186 patients. Int J Radiat Oncol Biol Phys 18: 755–761
Glass J, Hochberg FH, Gruber ML et al. (1992) The treatment of oligodendrogliomas and mixed oligodendroglioma-astrocytomas with PCV chemotherapy. J Neurosurg 76: 741–745
Greenberg HS, Chandler WF, Diaz RF et al. (1988) Intra-arterial bromodeoxyuridine radiosensitization and radiation in treatment of malignant astrocytomas. J Neurosurg 69: 500
Griffin BR, Shuman WP, Wisbeck W et al. (1988) Improved localization of infratentorial ependymoma by magnetic resonance imaging: implications for radiation treatment planning. J Neuro-oncol 6: 147–155
Griffin TW, Beaufait D, Blasko JC (1979) Cystic cerebellar astrocytoma in childhood. Cancer 44: 276–280
Gutin PH, Phillips TL, Wara WM et al. (1984) Brachytherapy of recurrent malignant brain tumors with removable high-activity iodine-125 sources. J Neurosurg 60: 61
Guttenberger R, Thames HD, Ang KK (1992) Is the experience with CHART compatible with experimental data? A new model of repair kinetics and computer simulations. Radiother Oncol 25: 280–286
Hartmann GH, Schlegel W, Sturm V et al. (1985) Cerebral radiation surgery using moving field irradiation at a linear accelerator facility. Int J Radiat Oncol Biol Phys 11: 1185
Healey EA, Barnes PD, Kupsky WJ et al. (1991) The prognostic significance of postoperative residual tumor in ependymoma. Neurosurg 28: 666–672
Hochberg FH, Pruitt A (1980) Assumptions in the radiotherapy of glioblastoma. Neurology 30: 907
Hochberg FH, Slotnick B (1980) Neuropsychologic impairment in astrocytoma survivors. Neurology 30: 172–177
Hochberg FH, Miller DC (1988) Primary central nervous system lymphoma. J Neurosurg 68: 835–853
Horwich A, Bloom HJG (1985) Optic gliomas: radiation therapy and prognosis. Int J Radiat Oncol Biol Phys 11: 1067–1079
Hoshino T (1984) A commentary on the biology and growth kinetics of low-grade and highgrade gliomas. J Neurosurg 61: 895–900
Jenkin D, Angyalfi S, Becker L et al. (1993) Optic glioma in children: surveillance, resection, or irradiation? Int J Radiat Oncol Biol Phys 25: 215–225
Jereb B, Reid A, Ahuja RK (1982) Patterns of failure in patients with medulloblastoma. Cancer 50: 2941–2947
Keim H, Potthoff PC, Schmidt K et al. (1987) Survival and quality of life after continuous accelerated radiotheraphy of glioblastomas. Radiother Oncol 9: 21
Kernohan JW, Sayre GP (1952) Tumors of the central nervous system. In: Atlas of Tumor Pathology; 1st Series; Section 10; fasc. 35. Armed Forces Institute of Pathology, Washington DC
Kim YH, Fayos JV (1977) Intracranial ependymomas. Radiology 124: 805–808
Kinsella TJ, Dobson PP, Mitchell JB et al. (1987) Enhancement of x-ray induced DNA damage by pre-treatment with halogenated pyrimidine analogs. Int J Radiat Oncol Biol Phys 13: 733
Kleinman GM, Hochberg FH, Richardson EP (1981) Systematic metastases from medulloblastoma: report of two cases and review of the literature. Cancer 48: 2296–2309
Kondziolka D, Lunsford LD, Coffey RJ et al. (1991) Stereotactic radiosurgery of meningiomas. J Neurosurg 74: 552–559
Kristiansen K, Hagen S, Kollevold T et al. (1981) Combined modality therapy of operated astrocytomas grade III and IV. Confirmation of the value of postoperative irradiation and lack of potentiation of bleomycin on survival time: a prospective multicenter trial of the Scandinavian Glioblastoma Study Group. Cancer 47: 649–652
Kurtz JM, Gelber R, Brady LW et al. (1981) The palliation of brain metastases in a favourable patient population: a randomized clinical trial by the radiation therapy oncology group. Int J Radiat Oncol Biol Phys 7: 891–895
Laing RW, Warrington AP, Graham J, Britton J, Hines F, Brada M (1993) Efficacy and toxicity of fractionated stereotactic radiotherapy in the treatment of recurrent gliomas (Phase I–II Study). Radiother Oncol 27: 22–29
Leibel SA, Sheline GE, Wara WM et al. (1975) The role of radiation therapy in the treatment of astrocytomas. Cancer 35: 1551–1557
Leibel SD, Sheline GE (1987) Radiation therapy for neoplasms of the brain. J Neurosurg 66: 1–22
Leibel S, Gutin P, Wara W et al. (1988) Survival and quality of life following interstitial implantation of removable high-activity iodine-125 sources for recurrent malignant gliomas (Abstract). Int J Radiat Oncol Biol Phys 15: 155
Leksell DG (1987) Stereotactic radiosurgery. Neurol Res 9: 60
Lindegaard KF, Mørk SJ, Eide GE et al. (1987) Statistical analysis of clinicopathological features, radiotherapy and survival in 170 cases of oligodendroglioma. J Neurosurg 67: 224–230
Ludgate CM, Douglas BG, Dixon PE et al. (1988) Superfractionated radiotherapy in grade HI, IV intracranial glioma. Int J Radiat Oncol Biol Phys 15: 1091
Ludwig CL, Smith MT, Godfrey AD et al. (1986) A clinicopathological study of 323 patients with oligodendroglioma. Ann Neurol 19: 15–21
Lutz W, Winston KR, Maleki N (1988) A system for stereotactic radiosurgery with a linear accelerator. Int J Radiat Oncol Biol Phys 14: 373
Lyons MK, Kelly PJ (1991) Posterior fossa ependymomas: report of 30 cases and review of the literature. Neurosurg 28: 659–665
MacDonald D, O’Brien R, Gilbert JG et al. (1989) Metastatic anaplastic oligodendroglioma. Neurology 39: 1593–1596
Marcus RB, Million RR (1990) The incidence of myelitis after irradiation of the cervical spinal cord. Int J Radiat Oncol Biol Phys 19: 3–8
Marks JP, Baglan RJ, Prassad SC et al. (1981) Cerebral radionecrosis: incidence and risk in relation to dose, time fractionation and volume. Int J Radiat Oncol Biol Phys 7: 243–252
Mastaglia FL, McDonald WI, Watson JV et al. (1976) Effects of X-radiation of the spinal cord: an experimental study of the morphological changes in central nerve fibres. Brain 99: 101–122
Mørk SJ, Løken AC (1977) Ependymoma. A follow up study of 101 cases. Cancer 40: 907–915
MRC Working Party (1983) A study of the effect of misonidazole in conjunction with radiotherapy for the treatment of grades 3 and 4 astrocytomas. A report from the MRC Working Party on misonidazole in gliomas. Br J Radiol 56: 673
Murray K, Kund L, Cox J (1986) Primary malignant lymphoma of the central nervous system. Results of treatment of 11 cases and review of the literature. J Neurosurg 65: 600
Nazar GB, Hoffman HJ, Becker LE et al. (1990) Infratentorial ependymomas in childhood: prognostic factors and treatment. J Neurosurg 72: 408–417
Nelson DF, Martz KL, Bonner H et al. (1992) Non-Hodgkin’s lymphoma of the brain: can high dose, large volume radiation therapy improve survival? Report on a prospective trial by The Radiation Therapy Oncology Group (RTOG): RTOG 8315. Int J Radiat Oncol Biol Phys 23: 9–17
Neuwelt EA, Goldman DL, Dahlborg SA et al. (1991) Primary CNS lymphoma treated with osmotic blood-brain-barrier disruption: prolonged survival and preservation of cognitive function. J Clin Oncol 9(9): 1580–1590
Packer RJ, Littman PA, Sposto RM et al. (1987) Results of a pilot study of hyperfractionated radiation therapy for children with brain stem gliomas. Int J Radiat Oncol Biol Phys 13: 1647
Packer RJ, Sutton LN, Atkins TE et al. (1989) A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results. J Neurosurg 70: 707–713
Palma L, Guidetti B (1985) Cystic pilocytic astrocytomas of the cerebral hemispheres. Surgical experience with 51 cases and long-term results. J Neurosurg 62: 811–815
Payne DG, Simpson WJ, Keen C et al. (1982) Malignant astrocytoma. Hyperfractionated and standard radiotherapy with chemotherapy in a randomized prospective clinical trial. Cancer 50: 2301–2306
Pezmer RD, Achambeau JO (1981) Brain tolerance unit: a method to estimate risk of radiation brain injury for various dose schedules. Int J Radiat Oncol Biol Phys 7: 397–402
Pierre-Kahn A, Hirsch JF, Roux FX et al. (1983) Intracranial ependymomas in childhood. Child’s Brain 10: 145–156
Reinhold HS, van Putten WLJ, Hopewell JW et al. (1984) The latent period in clinical radiation myelopathy. Int J Radiat Oncol Biol Phys 10: 2385–2387
Rorke LB, Gilles FH, Davis RL et al. (1985) Revision of the World Health Organization classification of brain tumours from childhood brain tumours. Cancer 56: 1869–1886
Rosenstock JG, Packer RJ, Bilaniuk L et al. (1985) Chiasmatic optic glioma treated with chemotherapy: a preliminary report. J Neurosurg 63: 862–866
Ross GW, Rubinstein LJ (1989) Lack of histopathological correlation of malignant ependymomas with postoperative survival. J Neurosurg 70: 31–36
Rubinstein LJ (1970) The definition of the ependymoblastoma. Arch Path 90: 35–45
Rubinstein LJ (1972) Tumours of the central nervous system. Atlas of Tumour Pathology, ser 2. Armed Forces Institution of Pathology, Washington DC, p 6
Ruifrok ACC, Kleiboer BJ, van der Kogel AJ (1992a) Fractionation sensitivity of the rat spinal cord during radiation retreatment. Radiother Oncol 25: 295–300
Ruifrok ACC, Kleiboer BJ, van der Kogel AJ (1992b) Radiation tolerance and fractionation sensitivity of the developing rat cervical spinal cord. Int J Radiat Oncol Biol Phys 24: 505–510
Ruifrok ACC, Kleiboer BJ, van der Kogel AJ (1992c) Reirradiation tolerance of the immature rat spinal cord. Radiother Oncol 23: 249–256
Salazar OM (1983) A better understanding of CNS seeding and a brighter outlook for postoperatively irradiated patients with ependymomas. Int J Radiat Oncol Biol Phys 9: 1231–1234
Salazar OM, Castro-Vita M, Van Houtte P et al. (1983) Improved survival in cases of intracranial ependymoma after radiation therapy. Late report and recommendations. J Neurosurg 59: 652–659
Salazar OM (1988) Ensuring local control in meningiomas. Int J Radiat Oncol Biol Phys 15: 501–504
Schultheiss TE, Stephens LC, Moor MH (1988) Analysis of the histopathology of radiation myelopathy. Int J Radiat Oncol Biol Phys 14: 27–32
Schultheiss TE, Stephens LC, Jiang GL et al. (1990) Radiation myelopathy in primates treated with conventional fractionation. Int J Radiat Oncol Biol Phys 19: 935–940
Shalet SM (1986) Irradiation induced growth failure. Clin Endocrinol Metab 15: 591–606
Shapiro WR (1986) Therapy of adult malignant brain tumours: what have the clinical trials taught us? Semin Oncol 13: 38
Shaw EG, Evans RG, Scheithauer BW et al. (1987) Postoperative radiotherapy of intracranial ependymoma in pediatric and adult patients. Int J Radiat Oncol Biol Phys 13: 1457–1462
Shaw EG, Daumas-Duport C, Scheithauer BW et al. (1989a) Radiation therapy in the management of low-grade supratentorial astrosytomas. J Neurosurg 70: 853–861
Shaw EG, Scheithauer BW, Gilbertson DT et al. (1989b) Postoperative radiotherapy of supratentorial low-grade gliomas. Int J Radiat Oncol Biol Phys 16: 663–668
Sheline GE, Boldrey E, Karlsberg P et al. (1964) Therapeutic considerations in tumours affecting the central nervous system: oligodendroglioma. Radiology 82: 84–89
Sheline GE, Wara W, Smith V (1980) Therapeutic irradiation and brain injury. Int J Radiat Oncol Biol Phys 6: 1215–1228
Sheline GE, (1986) Normal tissue tolerance and radiation therapy of gliomas of the adult brain. In: Bleehen NM (ed) Tumours of the Brain, Springer-Verlag, New York
Smith WJ, Gasson JA, Bourne SP et al. (1988) Immunoglobulin gene rearrangement and antigenic profile confirm B cell origin of primary cerebral lymphoma and indicate a mature phenotype. J Clin Path 41: 128–132
Stenning SP, Freedman LS, Bleehen NM (1987) An overview of published results from randomized studies of nitro-sources in primary high grade malignant glioma. Br J Cancer 56: 89
Sung D II, Havisiadis L, Chang CH (1978) Midline pineal tumors and suprasellar germinomas highly curable by irradiation. Radiology 128: 745–751
Sutcliffe SB, Gospodarowicz MK, Bush RS et al. (1985) Radiation therapy in localised non-Hodgkin’s lymphoma. Radiother Oncol 4: 211–223
Taylor BW, Marcus RB, Friedman WA et al. (1988) The meningioma controversy: postoperative radiation therapy. Int J Radiat Oncol Biol Phys 15: 299–304
Thames HD (1985) An “incomplete-repair” model for survival after fractionated and continuous irradiations. Int J Radiat Oncol Biol Phys 47: 319–339
Twijnstra A, Boon PJ, Lormans ACM et al. (1987) Neurotoxicity of prophylactic cranial irradiation in patients with small cell carcinoma of the lung. Eur J Cancer Clin Oncol 23: 983–986
Urie MM, Fullerton B, Tatsuzaki H et al. (1992) A dose response analysis of injury to cranial nerves and/or nuclei following proton beam radiation therapy. Int J Radiat Oncol Phys 23: 27–39
Vanuytsel L, Brada M (1991) The role of prophylactic spinal irradiation in localized intracranial ependymoma. Int J Radiat Oncol Phys 21: 825–830
Vanuytsel L, Bessel EM, Ashley SE et al. (1992) Intracranial ependymoma: long-term results of a policy of surgery and radiotherapy. Int J Radiat Oncol Phys 23: 313–319
Walker MD, Strike TA, Sheline GE (1979) An analysis of dose-effective relationship in the radiotherapy of malignant gliomas. Int J Radiat Oncol Phys 5: 1725
Wallner KE, Wara WM, Sheline GE et al. (1986) Intracranial ependymomas: results of treatment with partial or whole brain irradiation without spinal irradiation. Int J Radiat Oncol Phys 12: 1937–1941
Wallner KE, Gonzales M, Sheline GE (1988) Treatment of oligodendrogliomas with or without postoperative irradiation. J Neurosurg 68: 684–688
Wen BC, Hussey DH, Staples J et al. (1989) A comparison of the roles of surgery and radiation therapy in the management of craniopharyngiomas. Int J Radiat Oncol Phys 16: 17–24
Yassargil MG, Curcic M, Kis M, et al. (1990) Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients. J Neurosurg 73: 3–11
Zulch KJ (1980) Review article: Principles of the new World Health Organization (WHO) classification of brain tumours. Neuroradiology 19: 59–66
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Brada, M., Vanuytsel, L. (1995). Radiotherapy for Malignant Brain Tumours. In: Thomas, D.G.T., Graham, D.I. (eds) Malignant Brain Tumours. Springer, London. https://doi.org/10.1007/978-1-4471-1877-0_12
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