Advertisement

Chronic Carotid Glomitis

  • Donald Heath
  • Paul Smith

Abstract

A sparse, diffuse infiltrate of lymphocytes throughout the stroma of the carotid body appears to be an age-related change occurring in subjects over 50 years who show sustentacular cell proliferation around cell clusters or the effects of compression or ablation of glomic tissue by fibrous tissue (Hurst et al. 1985; see Chapter 4). In the elderly or aged, however, discrete, focal aggregations of lymphocytes are to be found. The appearances of these aggregates are so characteristic that they may be regarded as forming a distinct pathological entity which we have designated “chronic carotid glomitis” (Khan et al. 1989). In one study that we carried out, both carotid bodies were obtained at necropsy from each of 75 subjects, 38 male and 37 female, ranging in age from 14 to 90 years. The diffuse infiltration of lymphocytes ascribed to age and referred to above occurred on its own in 34 cases. It was found in two of 18 subjects under 50 years of age (11%) and in 32 of 57 subjects who were older than that (56%). In contrast, in 12 instances there were aggregates of lymphocytes which constitute chronic carotid glomitis.

Keywords

Plasma Cell Carotid Body Pulmonary Trunk Small Lymphocyte Lymphoid Aggregate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Chused TM, Hardin J A, Frank MM, Green I (1974) Identification of cells infiltrating the minor salivary glands in patients with Sjögren’s syndrome. J Immunol 112: 641–648PubMedGoogle Scholar
  2. Comroe JH (1962) In: de Reuck AVS, O’Connor M (eds) Ciba Foundation Symposium on pulmonary structure and function. Churchill, London, pp 70–73 (discussion)Google Scholar
  3. Edwards C, Heath D (1969) Microanatomy of glomic tissue of the pulmonary trunk. Thorax 24: 209–217PubMedCrossRefGoogle Scholar
  4. Heath D, Khan Q (1989) Focal chronic thyroiditis and chronic carotid glomitis. J Pathol 159: 29–34PubMedCrossRefGoogle Scholar
  5. Heath D, Khan Q, Nash J, Smith P (1989) Carotid body disease and the physician — chronic carotid glomitis. Postgrad Med J 65: 353–357PubMedCrossRefGoogle Scholar
  6. Hurst G, Heath D, Smith P (1985) Histological changes associated with ageing of the human carotid body. J Pathol 147: 181–187PubMedCrossRefGoogle Scholar
  7. Khan Q, Heath D (1990) Chronic carotid glomitis and the glomus pulmonale. J Clin Pathol 43: 39–42PubMedCrossRefGoogle Scholar
  8. Khan Q, Heath D, Nash J, Smith P (1989) Chronic carotid glomitis. Histopathology 14: 471–481PubMedCrossRefGoogle Scholar
  9. Krahl VE (1960) The glomus pulmonale. A preliminary report. Bull Sch Med Univ Maryland 45: 36–38PubMedGoogle Scholar
  10. Krahl VE (1962) The glomus pulmonale: its location and microscopic anatomy. In: de Reuck AVS, O’Connor M (eds) Ciba Foundation Symposium on pulmonary structure and function. Churchill, London, pp 53–69Google Scholar
  11. Lindahl G, Hedfors, E, Klareskog L, Forsum U (1985) Epithelial HLA-DR expression and T lymphocyte subsets in salivary glands in Sjögren’s syndrome. Clin Exp Immunol 61: 475–482PubMedGoogle Scholar
  12. MacDonald DG (1985) Alimentary tract. I: The oral cavity, salivary glands and oropharynx. In: Anderson JR (ed) Muir’s Textbook of Pathology 12th edit. Edward Arnold, London, pp 19.1–19. 12Google Scholar
  13. Misaki T, Konishi J, Nakashima T, Iida Y, Kasagi K, Endo K, Uchiyama T, Kuma K, Torizuka K (1985) Immunohistological phenotyping of thyroid infiltrating lymphocytes in Graves’ disease and Hashimoto’s thyroiditis. Clin Exp Immunol 60: 104–110PubMedGoogle Scholar
  14. Mitchell JD, Kirkham N, Machin D (1984) Focal lymphocytic thyroiditis in Southampton. J Pathol 144: 269–273PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Limited 1992

Authors and Affiliations

  • Donald Heath
    • 1
  • Paul Smith
    • 2
  1. 1.Department of PathologyUniversity of Liverpool Royal Liverpool University HospitalLiverpoolUK
  2. 2.Department of PathologyLiverpoolUK

Personalised recommendations