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Familial Motor Neuron Disease

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Motor Neuron Disease

Abstract

Familial motor neuron disease (FMND) constitutes approximately 5%–10% of cases of motor neuron disease (MND). Whilst in most families the pattern of inheritance is consistent with an autosomal-dominant trait, with age-dependent penetrance, a few cases appear to show an autosomal-recessive mode of inheritance. Statistical analysis shows that the likelihood of chance aggregation is improbable because affected members span several generations, come from different environmental and geographical regions, and the condition does not develop in spouses.

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Authors
  1. J. de Belleroche
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  2. P. N. Leigh
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  3. F. Clifford Rose
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Editors and Affiliations

  1. University Department of Neurology, Institute of Psychiatry and Kings College School of Medicine and Dentistry, De Crespigny Park, London, SE5 8AF, UK

    P. N. Leigh BSc, PhD, FRCP (Professor) (Professor)

  2. Department of Neurology, The Royal London Hospital, Whitechapel, London, E1 1BB, UK

    Michael Swash MD, FRCP, FRCPath (Consultant Neurologist) (Consultant Neurologist)

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© 1995 Springer-Verlag London Limited

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de Belleroche, J., Leigh, P.N., Clifford Rose, F. (1995). Familial Motor Neuron Disease. In: Leigh, P.N., Swash, M. (eds) Motor Neuron Disease. Springer, London. https://doi.org/10.1007/978-1-4471-1871-8_3

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  • DOI: https://doi.org/10.1007/978-1-4471-1871-8_3

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1873-2

  • Online ISBN: 978-1-4471-1871-8

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