Developmental Biology of Mammalian Myocardium

  • R. L. Gingell


The study of the process and control of the transitional cardiovascular physiology from the fetal to adult condition has brought enormous insight into the diagnosis, natural history and treatment of congenital, as well as acquired, cardiac abnormalities in children. It is now apparent that a remarkable passage also occurs in the metabolic maturation of the myocardium. The myocardial cell undergoes important changes in metabolic operations that include substrate preference, maintenance of cellular integrity, production and delivery of high energy phosphate, replication of the contractile apparatus as well as response to adverse metabolic and hemodynamic conditions. Remarkably, the functional capacity of the heart remains essentially constant throughout this period of differentiation. Indeed, the immature cardiovascular system demonstrates a striking capacity to accommodate severe physiologic burdens and metabolic alterations.


Sarcoplasmic Reticulum Rabbit Heart Immature Myocardium High Energy Phosphate Thymidine Kinase Activity 
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© Springer-Verlag London Limited 1992

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  • R. L. Gingell

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