The Reaction of Bone to Bone Cement in Animals and Humans
John Charnley revolutionised orthopaedic surgery and it is impossible to discuss the reaction to bone cement without this historical perspective, because our view has changed over the years. In the 1960s and early 1970s, what we discussed was whether a 2-mm radiolucency or a 1-mm radiolucency was acceptable and whether it was the normal response of bone to bone cement. If we looked at the interfaces histologically in those years, we invariably found a thick fibrous membrane between the bone and the bone cement. Why was the fibrous tissue there? Was it because of the bone cement as such, or the wear of the polyethylene socket? Was it due to metal corrosion, or the fragmentation of the bone cement surface? All these phenomena could be traced in the membrane, which was very bewildering (Mirra et al. 1976).
KeywordsBone Cement Foreign Body Giant Cell Osseous Tissue Barium Sulphate Implant Bone Interface
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References and Further Reading
- Linder L, Hansson H-A (1983) Ultra-structural aspects of the interface between bone and cement in man. J Bone Joint Surg (Br) 65:646–649Google Scholar