Abstract
The concept that cancer arises as a result of mutations in cellular genes was confirmed around 1981 by Weinberg and others. They found that DNA isolated from a human bladder carcinoma cell line could transform NIH/3T3 cells, an established cell line of mouse origin, into tumourigenic cells. When a similar experiment was carried out with DNA from normal human tissue, no such transformation was observed. This result indicated that the DNA from the tumour cells contained a gene that had acquired transforming activity, presumably due to a mutation.
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© 1990 Springer-Verlag London Limited
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van der Eb, A.J. (1990). Viruses, Oncogenes and Cancer. In: de Vries, R.R.P., Cohen, I.R., van Rood, J.J. (eds) The Role of Micro-organisms in Non-infectious Diseases. Argenteuil Symposia. Springer, London. https://doi.org/10.1007/978-1-4471-1796-4_7
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DOI: https://doi.org/10.1007/978-1-4471-1796-4_7
Publisher Name: Springer, London
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