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Streptococci and Rheumatic Heart Disease

  • Chapter
The Role of Micro-organisms in Non-infectious Diseases

Part of the book series: Argenteuil Symposia ((ARGENTEUIL))

Abstract

The selection of rheumatic fever as the introductory topic for this volume may or may not be appropriate. On the one hand, few diseases have done more to stimulate the concept of “molecular mimicry” in autoimmunity. On the other hand, autoimmunity remains so far but a popular concept for the pathogenesis of this disease and is not the proven pathogenetic mechanism. The methodology of immunology has become increasingly powerful, however, and it may now be possible to identify on a molecular basis which (if any) of the group A streptococcal epitopes that are cross-reactive with human tissues are, or are not, relevant to the cardiac injury of the disease. It is this cardiac injury that makes rheumatic fever so important to the human race, and particularly to the medically neglected communities of the world [1].

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Authors
  1. G. H. Stollerman
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Editors and Affiliations

  1. Department of Immunohaematology and Blood Bank, University Hospital, 2333 AA, Leiden, The Netherlands

    René R. P. de Vries  & Jon J. van Rood  & 

  2. Department of Cell Biology, The Weizmann Institute of Science, PO Box 26, 76 100, Rehovot, Israel

    Irun R. Cohen

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Stollerman, G.H. (1990). Streptococci and Rheumatic Heart Disease. In: de Vries, R.R.P., Cohen, I.R., van Rood, J.J. (eds) The Role of Micro-organisms in Non-infectious Diseases. Argenteuil Symposia. Springer, London. https://doi.org/10.1007/978-1-4471-1796-4_2

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  • DOI: https://doi.org/10.1007/978-1-4471-1796-4_2

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1798-8

  • Online ISBN: 978-1-4471-1796-4

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