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What Drives Autoantibodies? The Evidence From Spontaneous Human Autoimmune Diseases

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The Role of Micro-organisms in Non-infectious Diseases

Part of the book series: Argenteuil Symposia ((ARGENTEUIL))

Abstract

Although the fathers of immunology recognized from the beginning the danger that a competent immune system posed to its possessor, it was decades before an actual disease was connected to an antibody directed at a self-antigen. Soon, however, other antibodies directed at self components turned up in diseases, but their connection to the disease was far less clear than in Coombs-positive haemolytic anaemia. In fact, autoantibodies have become, especially in the rheumatological autoimmune diseases, far more numerous than plausible explanations of how they got there and what they are doing.

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References

  1. Nossal GJ (1989) Immunologic tolerance: collaboration between antigen and lymphokines. Science 345: 147–153

    Article  Google Scholar 

  2. Goodnow CC, Crosbie J, Adelstein S et al. (1988) Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334: 676–682

    Article  PubMed  CAS  Google Scholar 

  3. Nemazee DA, Biiurki K (1989) Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 337: 562–566

    Article  PubMed  CAS  Google Scholar 

  4. Shlomchik MJ, Aucoin AH, Pisetsky DS, Weigert MG (1987) Structure and function of anti- DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci USA 84: 9150–9154

    Article  PubMed  CAS  Google Scholar 

  5. Marion TN, Bothwell AL, Briles DE, Janeway CA Jr (1989) IgG anti-DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection. J Immunol 142: 4269–4274

    PubMed  CAS  Google Scholar 

  6. Tojo T, Friou GJ, Spiegelberg HL (1979) Immunoglobulin G subclass of human antinuclear antibodies. Clin Exp Immunol 6: 145–151

    Google Scholar 

  7. Lieu TS, Reimer CB, Sontheimer RD (1988) Immunoglobulin class and subclass profile of the Ro/SS-A autoantibody response. J Invest Dermatol 90: 158–164

    Article  PubMed  CAS  Google Scholar 

  8. Pearce DC, Yount WJ, Eisenberg RA (1986) Subclass restriction of anti-SS-B ( La) autoantibodies. Clin Immunol Immumopathol 38: 111–119

    Article  CAS  Google Scholar 

  9. Davies TF, Weber CM, Wallack P, Platzer M (1986) Restricted heterogeneity and T cell dependence of human thyroid autoantibody immunoglobulin G subclasses. J Clin Endocrinol Metab 62: 945–949

    Article  PubMed  CAS  Google Scholar 

  10. McLachlan SM, Feldt-Rasmussen U, Young ET et al. (1987) IgG subclass distribution of thyroid autoantibodies: ‘fingerprint’ of an individual’s response to thyroglobulin and thyroid microsomal antigen. Clin Endocrinol (Oxf) 26: 335–346

    Article  CAS  Google Scholar 

  11. Bonfa E, Chu JL, Brot N, Elkon KB (1987) Lupus anti-ribosomal P peptide antibodies show limited heterogeneity and are predominantly of the IgG1 and IgG2 subclasses. Clin Immunol Immunopathol 45: 129–138

    Article  PubMed  CAS  Google Scholar 

  12. Jones CC, Hamilton RG, Jordon RE (1988) Subclass distribution of human IgG autoantibodies in pemphigus. J Clin Immunol 8: 43–49

    Article  PubMed  CAS  Google Scholar 

  13. Eisenberg RA, Dyer K, Craven SY, Fuller CR, Yount WJ (1985) Subclass restriction and polyclonality of the systemic lupus erythematosus marker antibody anti-Sm. J Clin Invest 75: 1270–1277

    Article  PubMed  CAS  Google Scholar 

  14. Rødgaard A, Nielsen FC, Djurup R, Somnier F, Gammeltoft S (1987) Acetylcholine receptor antibody in myasthenia gravis: predominance of IgG subclasses 1 and 3. Clin Exp Immunol 67: 82–88

    PubMed  Google Scholar 

  15. Cohen PL, Cheek RL, Hadler JA, Yount WJ, Eisenberg RA (1987) The subclass distribution of human IgG rheumatoid factor. J Immunol 139: 1466–1471

    PubMed  CAS  Google Scholar 

  16. Miller RW, Twitty SA, Biswas T, Plotz PH (1990) The origin and regulation of a disease-specific autoantibody response: antigenic epitopes, spectrotype stability, and isotype restriction of anti- Jo-1 autoantibodies. J Clin Invest 85: 468–475

    Article  PubMed  CAS  Google Scholar 

  17. Siekevitz M, Kocks C, Rajewsky K, Dildrop R (1987) Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses. Cell 48: 757–770

    Article  PubMed  CAS  Google Scholar 

  18. Shlomchik MJ, Marshak-Rothstein A, Wolfowicz CB, Rothstein LT, Weigert MG (1987) The role of clonal selection and somatic mutation in autoimmunity. Nature 328: 805–811

    Article  PubMed  CAS  Google Scholar 

  19. Behar SM, Scharff MD (1988) Somatic diversification of the S107 (T15) VH11 germ-line gene that encodes the heavy-chain variable region of antibodies to double-stranded DNA in (NZB x NZW) F1 mice. Proc Natl Acad Sci USA 85: 3970–3974

    Article  PubMed  CAS  Google Scholar 

  20. Eisenberg RA, Craven SY, Cohen PL (1987) Isotype progression and clonality of anti-Sm autoantibodies in MRL/Mp-1pr/1pr mice. J Immunol 139: 728 - 733

    PubMed  CAS  Google Scholar 

  21. Delves PJ, Roitt IM (1988) Long term spectrotypic and idiotypic stability of thyroglobulin autoantibodies in patients with Hashimoto’s thryoiditis. Clin Exp Immunol 71: 459–463

    PubMed  CAS  Google Scholar 

  22. Askonas BA, Williamson AR, Wright BEG (1970) Selection of a single antibody-forming cell clone and its propagation in syngeneic mice. Proc Natl Acad Sci USA 67: 1398–1403

    Article  PubMed  CAS  Google Scholar 

  23. Horsfall AC, Venables PJW, Mumford PA, Maini RN (1986) Idiotypes on antibodies to the La(SS-B) antigen are restricted and associated with the antigen binding site. Clin Exp Immunol 63: 395–401

    PubMed  CAS  Google Scholar 

  24. Fong S, Chen P, Gilbertson T, Weber J, Fox R, Carson D (1986) Expression of three cross- reactive idiotypes on rheumatoid factor from patients with autoimmune diseases and seropositive adults. J Immunol 137: 122–128

    PubMed  CAS  Google Scholar 

  25. Bozzoni I, Annesi F, Beccari E, Fragapane P, Pierandrei-Amaldi P, Amaldi F (1984) Splicing of Xenopus laevis ribosomal protein RNAs is inhibited in vivo by antisera to ribonucleoproteins containing U1 small nuclear RNA. J Molec Biol 180: 1173–1178

    Article  PubMed  CAS  Google Scholar 

  26. Mathews MB, Bernstein RM (1983) Myositis autoantibody inhibits histidyl-rRNA synthetase: a model for autoimmunity. Nature 304: 177–179

    Article  PubMed  CAS  Google Scholar 

  27. Mathews MB, Reichlin M, Hughes GR, Bernstein RM (1984) Anti-threonyl-tRNA synthetase, a second myositis-related autoantibody. J Exp Med 160: 420–434

    Article  PubMed  CAS  Google Scholar 

  28. Bunn CC, Bernstein RM, Mathews MB (1986) Autoantibodies against alanyl-tRNA synthetase and tRNA(ALA) coexist and are associated with myositis. J Exp Med 163: 1281–1291

    Article  PubMed  CAS  Google Scholar 

  29. Dang CV, Tan EM, Traugh JA (1988) Myositis autoantibody reactivity and catalytic function of threonyl-tRNA synthetase. FASEB J 2: 2376–2379

    PubMed  CAS  Google Scholar 

  30. Targoff IN, Arnett FC, Berman L, O’Brien C, Reichlin M (1989) Anti-KJ: a new antibody associated with the syndrome of polymyositis and interstitial anti-centromere antibodies. J Clin Invest 77: 426–430

    Google Scholar 

  31. Prelich G, Tan CK, Kostura M et al. (1987) Functional identity of proliferating cell nuclear antigen and a DNA polymerase-delta auxiliary protein. Nature 326: 517–520

    Article  PubMed  CAS  Google Scholar 

  32. Shero JH, Bordwell B, Rothfield NF, Earashaw WC (1986) High titers of autoantibodies to topoisomerase I (Scl-70) in sera from scleroderma patients. Science 231: 737–740

    Article  PubMed  CAS  Google Scholar 

  33. Yamanaka H, Willis EH, Carson DA (1989) Human autoantibodies to poly(adenosine diphosphate-ribose) polymerase recognize cross-reactive epitopes associated with the catalytic site of the enzyme. J Clin Invest 83: 180–186

    Article  PubMed  CAS  Google Scholar 

  34. Van de Water J, Gershwin ME, Leung P, Ansari A, Coppel RL (1988) The autoepitope of the 74- kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase. J Exp Med 167: 1791–1799

    Article  PubMed  Google Scholar 

  35. Van de Water J, Fregeau D, Davis P et al. (1988) Autoantibodies of primary biliary cirrhosis recognize dihydrolipamide acetyltransferase and inhibit enzyme function. J Immunol 141: 2321–2324

    PubMed  Google Scholar 

  36. Chan EK, Tan EM (1986) Epitopes and structural domains of a RNA-binding nuclear protein, SS-B/La: similarities with adenovirus DNA-binding protein. Scand J Rheumatol (Suppl) 61: 102–105

    CAS  Google Scholar 

  37. Chan EK, Francoeur AM, Tan EM (1986) Epitopes, structural domains, and asymmetry of amino acid residues in SS-B/La nuclear protein. J Immunol 136: 3744–3749

    PubMed  CAS  Google Scholar 

  38. St Clair EW, Pisetsky DS, Reich CF, Keene JD (1988) Analysis of autoantibody binding to different regions of the human La antigen expressed in recombinant fusion proteins. J Immunol 141: 4173–4180

    Google Scholar 

  39. Rauh AJ, Hornig H, Luuhrmann R (1988) At least three distinct B cell epitopes reside in the C- terminal half of La protein, as determined by a recombinant DNA approach. Eur J Immunol 18: 2049–2057

    Article  PubMed  CAS  Google Scholar 

  40. Lieu T-S, McCauliffe DP, Arnett FC et al. (1989) Epitope mapping of the human Wil-2 cell Ro/ SS-A (Ro) autoantigenic polypeptide. Arthritis Rheum 32: S26 (abstract)

    Google Scholar 

  41. Reeves WH, Sthoeger ZM (1989) Molecular cloning of cDNA encoding the p70 ( Ku) lupus autoantigen. J Biol Chem 264: 5047–5052

    PubMed  CAS  Google Scholar 

  42. Habets WJ, Sillekens PT, Hoet MH, McAllister G, Lerner MR, van Venrooij WJ (1989) Small nuclear RNA-associated proteins are immunologically related as revealed by mapping of autoimmune reactive B-cell epitopes. Proc Natl Acad Sci USA 86: 4674–4678

    Article  PubMed  CAS  Google Scholar 

  43. Fresco LD, Keene JD (1989) Leucine periodicity of U2 snRNP autoantigen A’ implicated in U2 snRNP protein:protein interactions. Sitzungsberichte Heidelberger Akad Wissenschaften Mathematisch-naturwissenschaftliche Klasse 4: 15–16 (abstract)

    Google Scholar 

  44. Takeda Y, Wang GS, Sharp GC (1989) Immunological characterization of IgM class autoantibo¬dies against Sm-antigenic B’/B and D polypeptides of U small nuclear riboproteins (snRNPs). Sitzungsberichte Heidelberger Akad Wissenschaften. Mathematisch-naturwissenschaftliche Klasse 4: 92–94 (abstract)

    Google Scholar 

  45. Habets WJ (1989) Mapping of autoimmune reactive sites on snRNP proteins. Sitzungsberichte Heidelberger Akad Wissenschaften Mathematisch-naturwissenschaftliche Klasse 4: 26–27 (abstract)

    Google Scholar 

  46. Guldner HH, Netter HJ, Szostecki C, Lakomek HJ, Will H (1988) Epitope mapping with a recombinant human 68-kDa ( U1) ribonucleoprotein antigen reveals heterogeneous autoantibody profiles in human autoimmune sera. J Immunol 141: 469–475

    PubMed  CAS  Google Scholar 

  47. Bonfa E, Parnassa AP, Rhoads DD, Roufa DJ, Wool IG, Elkon KB (1989) Anti-ribosome S10 antibodies in patients with lupus and MRL/1pr mice. Arthritis Rheum 32: S20 (abstract)

    Article  Google Scholar 

  48. Targoff IN, Johnson AE, Miller FW (1988) Polymyositis and antibody to the signal recognition particle. Clin Res 36: 537A (abstract)

    Google Scholar 

  49. Rubin RL, Burlingame RW (1989) Drug induced anti-histone antibodies reflect nucleosomal substructures. Sitzungsberichte Heidelberger Akad Wissenschaften Mathematisch-naturwissenschaftliche Klasse 4: 76–78 (abstract)

    Google Scholar 

  50. Earnshaw W, Bordwell B, Marino C, Rothfield N (1986) Three human chromosomal autoanti- gens are recognized by sera from patients with lung disease. J Clin Invest 84: 162 - 172

    Google Scholar 

  51. Deutscher SL, Keene JD (1988) A sequence-specific conformational epitope on U1 RNA is recognized by a unique autoantibody. Proc Natl Acad Sci USA 85:3299 –3303

    Article  PubMed  CAS  Google Scholar 

  52. Lutz-Freyermuth C, Keene JD (1989) The U1 RNA-binding site of the U1 small nuclear ribonucleoprotein (snRNP)-associated A protein suggests a similarity with U2 snRNPs. Molec Cell Biol 9: 2975–2982

    PubMed  CAS  Google Scholar 

  53. Plotz PH (1983) Autoantibodies are anti-idiotype antibodies to antiviral antibodies. Lancet ii: 824–826

    Google Scholar 

  54. Chan EK, Tan EM (1987) Human autoantibody-reactive epitopes of SS-B/La are highly conserved in comparison with epitopes recognized by murine monoclonal antibodies. J Exp Med 166: 1627–1640

    Article  PubMed  CAS  Google Scholar 

  55. Waite K, Miller FW, Plotz PH (1989) Anti-Jo-1 antibodies are directed at an evolutionarily- conserved conformational site on human histidyl-tRNA synthetase. Sitzungsberichte Heidel-berger Akad Wissenschaften Mathematisch-naturwissenschaftliche Klasse 4: 100–101 (abstract)

    Google Scholar 

  56. Francoeur AM, Peebles CL, Gompper PT, Tan EM (1986) Identification of Ki (Ku, p70/p80) autoantigens and analysis of anti-Ki autoantibody reactivity. J Immunol 136: 1648–1653

    PubMed  CAS  Google Scholar 

  57. Haaf T, Machens A, Schmid M (1989) Human autoantibodies to synaptonemal complex. Sitzungsberichte Heidelberger Akad Wissenschaften Mathematisch-naturwissenschaftliche Klasse 4: 24–25 (abstract)

    Google Scholar 

  58. Huff JP, Roos G, Peebles CL et al. (1989) Structural analysis of the epitopic sites of PCNA/ cyclin. Arthritis Rheum 32: S80 (abstract)

    Google Scholar 

  59. Stiemer R, Gausepohl H, Mirshahi M et al. (1989) Localization of an immunopathologically important epitope in the bovine retinal S-antigen by the pepscan method. Sitzungsberichte Heidelberger Akad Wissenschaften Mathematisch-naturwissenschaftliche Klasse 4: 88–91 (abstract)

    Google Scholar 

  60. Elkon K, Skelly S, Parnassa A et al. (1986) Identification and chemical synthesis of a ribosomal protein antigenic determinant in systemic lupus erythematosus. Proc Natl Acad Sci USA 83: 7419–7423

    Article  PubMed  CAS  Google Scholar 

  61. Berzofsky JA (1985) Intrinsic and extrinsic factors in protein antigenic structure. Science 229: 932–940

    Article  PubMed  CAS  Google Scholar 

  62. Barlow DJ, Edwards MS, Thornton JM (1986) Continuous and discontinuous protein antigenic determinants. Nature 322: 747–748

    Article  PubMed  CAS  Google Scholar 

  63. Diakun KR, Matta KL (1989) Synthetic antigens as immunogens: Part III. Specificity analysis of an anti-anti-idiotypic antibody to a carbohydrate tumor-associated antigen. J Immunol 142:2037 –2040

    Google Scholar 

  64. ter Borg EJ, Horst G, Hummel E, Jaarsma D, Limburg PC, Kallenberg CG (1988) Sequential development of antibodies to specific Sm polypeptides in a patient with systemic lupus erythematosus: evidence for independent regulation of anti-double-stranded DNA and anti-Sm antibody production. Arthritis Rheum 31: 1563–1567

    Article  PubMed  Google Scholar 

  65. Yamamoto K, Kohsaka H, Miura H, et al. (1989) Epitope progression in autoantibody production suggested by epitope mappings of SS-B/La and U2snRNP B” Protein. Sitzungsberichte Heidelberger Akad Wissenschaften Mathematisch-naturwissenschaftliche Klasse 4: 107–108 (abstract)

    Google Scholar 

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Authors
  1. P. H. Plotz
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Editors and Affiliations

  1. Department of Immunohaematology and Blood Bank, University Hospital, 2333 AA, Leiden, The Netherlands

    René R. P. de Vries  & Jon J. van Rood  & 

  2. Department of Cell Biology, The Weizmann Institute of Science, PO Box 26, 76 100, Rehovot, Israel

    Irun R. Cohen

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Plotz, P.H. (1990). What Drives Autoantibodies? The Evidence From Spontaneous Human Autoimmune Diseases. In: de Vries, R.R.P., Cohen, I.R., van Rood, J.J. (eds) The Role of Micro-organisms in Non-infectious Diseases. Argenteuil Symposia. Springer, London. https://doi.org/10.1007/978-1-4471-1796-4_10

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  • DOI: https://doi.org/10.1007/978-1-4471-1796-4_10

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  • Online ISBN: 978-1-4471-1796-4

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