Abstract
The arthropod-borne protozoan parasitoses caused by Plasmodium sp have produced incalculable human misery, morbidity, and mortality since antiquity; it is clear that Plasmodium sp is related to the coccidia (Chap. 4) (Bruce-Chwatt 1988a), and that the primate-vector cycle was established around 30 million years ago. It seems certain that early man, in the cradle of civilization of Africa (Stringer 1988; Stringer and Andrews 1988), must have been subjected to this group of infections. ‘Malaria’, which replaced the older term ague during the eighteenth century and is derived from the Italian description mal aria (poisonous air), is not a single disease. Human infection by four separate protozoan parasites belonging to the genus Plasmodium (which probably evolved from intestinal coccidia millions of years ago), presents as four diverse and characteristic clinical entities (Spencer and Strickland 1984; Bruce-Chwatt 1985; Haworth 1987; Cook 1989a). That produced by P falciparum causes an acute and potentially lethal illness (‘malignant tertian’ malaria, in the older terminology) while at the opposite end of the spectrum, P malariae produces a very chronic infection that may continue, often without serious morbidity, for 50 years or more (Table 1.1.). Diseases with intermediate clinical presentations result from infection with P vivax and P ovale; though neither is characteristically associated with acute mortality or great chronicity, both result in considerable subacute morbidity.
He is so shak’d of a burning quotidian tertian, that it is most lamentable to behold. William Shakespeare (1564–1616), Henry V, II,i,123
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References
Aikawa M (1988) Human cerebral malaria. Am J Trop Med Hyg 39: 3–10
Avidor B, Golenser J, Schutte CHJ, Cox GA, Isaacson M, Sulitzeanu D (1987) A radioimmunoassay for the diagnosis of malaria. Am J Trop Med Hyg 37: 225–229
Bajpai R, Dutta GP, Vishwakarma RA (1989) Blood shizontocidal activity of a new antimalarial drug, arteether (α/β), against Plasmodium knowlesi in rhesus monkeys. Trans R Soc Trop Med Hyg 83: 484
Ballou WR, Hoffman, SL, Sherwood JA, Hollingdale MR, Neva FA, Hockmeyer WT, Gordon DM, Schneider I, Wirtz RA, Young JF, Wasserman GF, Reeve P, Diggs CL, Chulay JD (1987) Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine. Lancet 1: 1277–1281
Bradley AK, Greenwood BM, Greenwood AM, Marsh, K, Byass P, Tulloch S, Hayes R (1986) Bed-nets (mosquito-nets) and morbidity from malaria. Lancet 2: 204–207
Brandicourt O, Druilhe P, Brasseur P, Turk P, Diquet B, Datry A, Danis M, Gentilini M (1986) High level of chloroquine resistance in seven Plasmodium falciparum malaria cases from the Congo and Gabon. Trans R Soc Trop Med Hyg 80: 906–907
Bras J le, Deloron P, Charmot G (1983) Dichlorquinazine (a 4-aminoquinoline) effective in vitro against chloroquine-resistant Plasmodim falciparum. Lancet 1: 73–74
Bras J le, Hatin I, Bouree P, Coco-Cianci O, Garin J-P, Rey M, Charmot G, Roue R (1986) Chloroquine-resistant falciparum malaria in Benin. Lancet 2: 1043–1044
Brasseur P, Druilhe P, Kouamouo J, Moyou SR (1987a) Emergence of Plasmodium falciparum chloroquine resistance in the Sahel part of West Africa. Trans R Soc Trop Med Hyg 81: 162–163
Brasseur P, Pathe-Diallo M, Druilhe P (1987b) Low sensitivity to chloroquine and quinine of Plasmodium falciparum isolates from Guinea in March 1986. Am J Trop Med Hyg 37:452–454
Brook MG, Karet F, Lewis DA, Uriel A, Weir WRC (1989) Interpretation of blood films in diagnosis of malaria. Lancet ii:619
Bruce-Chwatt LJ (1983) Malaria and pregnancy. Br Med J 286: 1457–1458
Bruce-Chwatt LJ (1985) Essential malariology, 2nd edn. Heinemann, London, pp 51–72, 210–260
Bruce-Chwatt LJ (1987a) From Laveran’s discovery to DNA probes: new trends in diagnosis of malaria. Lancet 2: 1509–1511
Bruce-Chwatt LJ (1987b) The challenge of malaria vaccine: trials and tribulations. Lancet 1: 371–373
Bruce-Chwatt LJ (1988a) History of malaria from prehistory to eradication. In: Wernsdorfer WH, McGregor I (eds) Malaria: principles and practice of malariology. Churchill Livingstone, Edinburgh, pp 1–59
Bruce-Chwatt LJ (1988b) Three hundred and fifty years of the Peruvian fever bark. Br Med J 296: 1486–1487
Bruce-Chwatt LJ (1988c) Cinchona and its alkaloids: 350 years. NY State J Med 88: 318–322
Burnham G, Harries A, Macheso A, Wirima J, Molyneux M (1989) Chloroquine-induced pruritus in Malawi: lack of association with onchocerciasis. Trans R Soc Trop Med Hyg 83: 527–528
Campbell GH, Brandling-Bennett AD, Roberts JM, Collins FH, Kaseje DCO, Barber AM, Turner A (1987) Detection of antibodies in human sera to the repeating epitope of the circumsporozoite protein of Plasmodium falciparum using the synthetic peptide (NANP)3 in an enzyme-linked immunosorbent assay ( ELISA ). Am J Trop Med Hyg 37: 17–21
Chanthavanich P, Looaressuwan S, White NJ, Warrell DA, Warrell MJ, DiGiovanni JH, Bredow J. von (1985) Intragastric mefloquine is absorbed rapidly in patients with cerebral malaria. Am J Trop Med Hyg 34: 1028–1036
Childs GE, Haüsler B, Milhous W, Chen C, Wimonwattrawatee T, Pooyindeessss N, Boudreau EF (1988) In vitro activity of pyronaridine against field isolates and reference clones of Plasmodium falciparum. Am J Trop Med Hyg 38: 24–29
Chiodini PL, Somerville M, Salam I, Tubbs HR, Wood MJ, Ellis CJ (1985) Exchange transfusion in severe falciparum malaria. Trans R Soc Tro Med Hyg 79: 865–866
Collignon P, Hehir J, Mitchell D (1989) Successful treatment of falciparum malaria in pregnancy with mefloquine. Lancet 1: 967
Cook GC (1980) The tropical splenomegaly syndrome and other splenic diseases in the tropics. In: Tropical gastroenterology. Oxford University Press, Oxford, pp 205–221
Cook GC (1986a) Plasmodium falciparum infection: problems in prophylaxis and treatment in 1986. Q J Med 61:1091–1115
Cook GC (1986b) Serious problems with antimalarial drugs. J Infect 13: 1–4
Cook GC (1988a) Prevention and treatment of malaria. Lancet 1: 32–37
Cook GC (1988b) Chemotherapy of parasitic infections. Curr Opin Infect Dis 1: 423–438
Cook GC (1988c) Malaria prophylaxis and treatment: present and future. Curr Med Lit: Infect Dis 2: 1–5
Cook GC (1989a) The great malaria problem: where is the light at the end of the tunnel? J Infect 18: 1–10
Cook GC (1989b) The great malaria problem. Natl Med J India 2: 57
Cook GC (1990) Hepatic structure and function in experimental and human malaria. In: Bianchi L (ed) Infectious diseases of the liver. MTP Press Lancaster (in press)
Coulaud JP, Bras J le, Matheron S, Moriniere B, Saimot AG, Rossignol JF (1986) Treatment of imported cases of falciparum malaria in France with halofantrine. Trans R Soc Trop Med Hyg 80: 615–617
Cowden WB, Butcher GA, Hunt NH, Clark IA, Yoneda F (1987) Antimalarial activity of a riboflavin analog against Plasmodium vinckei in vivo and Plasmodium falciparum in vitro. Am J Trop Med Hyg 37: 495–500
Cox FEG (1988a) Vaccine development: which way for malaria? Nature 331: 486–487
Cox FEG (1988b) Malaria vaccines: the shape of things to come. Nature 333: 702
Crane GG (1986) Hyperreactive malarious splenomegaly (tropical splenomegaly syndrome). Parasitol Today 2: 4–9
Crane GG, Gardner A, Hudson P, Hudson B, Voller A (1977) Malarial antibodies in tropical splenomegaly syndrome in Papua New Guinea. Trans R Soc Trop Med Hyg 71: 308–314
Deloron P, Le Bras J, Savel J, Coulaud JP (1987) Antibodies to the PF155 antigen of Plasmodium falciparum: measurement by cell-ELISA and correlation with expected immune protection. Am J Trop Med Hyg 37: 22–26
DeSilva HJ, Goonetilleke AKE, Senaratna N, Ramesh N, Jayawickrama US, Jayasinghe KSA, Amarasekera LR (1988) Skeletal muscle necrosis in severe falciparum malaria. Br Med J 296: 1039
Dutta P, Pinto J, Rivlin R (1985) Antimalarial effects of riboflavin deficiency. Lancet 2: 1040–1043
Editorial (1983) Malaria in pregnancy. Lancet 2: 84–85
Editorial (1985) Plasmodium falciparum: a major health hazard to Africans and Asians returning home. Lancet 2: 871–872
Editorial (1989) Halofantrine in the treatment of malaria. Lancet 2: 537–538
Edstein MD, Veenendaal JR, Rieckmann KH, O’Donoghue M (1988) Failure of dapsone/ pyrimethamine plus chloroquine against falciparum malaria in Papua New Guinea. Lancet 1: 237
Elford BC, Roberts MF, Phillipson JD, Wilson RJM (1987) Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones. Trans R Soc Trop Med Hyg 81: 434–436
Ellis CJ (1988) Death despite malaria prophylaxis. Br Med J 296: 952
Esposito R (1985) Emetine and metronidazole as antimalarial drugs. Lancet 2: 784
Fitch CD (1986) Antimalarial schizontocides: ferriprotoporphyrin IX interaction hypothesis. Parasitol Today 2: 330–331
Fogh S, Schapira A, Bygbjerg IC, Jepsen S, Mordhorst CH, Kuijlen K, Ravn P, Rønn A, Gøtzsche PC (1988) Malaria chemoprophylaxis in travellers to east Africa: a comparative prospective study of chloroquine plus proguanil with chloroquine plus sulfadoxine-pyrimethamine. Br Med J 296: 820–822
Garnham PCC (1988) Hypnozoites and ‘relapses’ in Plasmodium vivax and in vivax-like malaria. Trop Geog Med 40: 187–195
Gasquet M, Atouk A, Samat A, Timon-David P, Viala A (1987) In vitro chemosensitivity of Plasmodium falciparum to four chloroquine derivatives. Ann Trop Med Parasitol 81: 355–358
Geary TG, Jensen JB (1983) Effects of antibiotics on Plasmodium falciparum in vitro. Am J Trop Med Hyg 32: 221–225
Geary TG, Jensen JB (1986) Protozoan infections of man: malaria. In: Campbell WC, Rew RS (eds) Chemotherapy of parasitic diseases. Plenum Press, New York, pp 87–114
Ginsburg H (1988) Effect of calcium antagonists on malaria susceptibility to chloroquine. Parasitol Today 4: 209–211
Gubler J (1988) Sulfadoxine-pyrimethamine resistant malaria from west or central Africa. Br Med J 296: 433
Hadley TJ, Chulay JD (1988) Perspectives on immunization against malaria. In: Leech JH, Sande MA, Root RK (eds) Parasitic infections. Churchill Livingstone, New York and Edinburgh, pp 285–310
Harinasuta T, Bunnag D, Lasserre R, Leimer R, Vinijanont S (1985) Trials of mefloquine in vivax and of mefloquine plus ‘Fansidar’ in falciparum malaria. Lancet 1: 885–888
Hatton CSR, Peto TEA, Bunch C, Pasvol G, Russell SJ, Singer CRJ, Edwards G, Winstanley P (1986) Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. Lancet 1: 411–414
Haworth J (1987) Malaria in man: its epidemiology, clinical aspects and control. Trop Dis Bull 84: R1–R51
Hernborg A (1985) Stevens-Johnson syndrome after mass prophylaxis with sulfadoxine for cholera in Mozambique. Lancet 2: 1072–1073
Higgins DG, McConnell DJ, Sharp PM (1989) Malarial proteinase? Nature 340: 604
Hoffman SL (1986) Treatment of malaria. In: Strickland GT (ed) Clinics in tropical medicine and communicable diseases, vol 1. Saunders, Philadelphia, pp 171–224
Hoffman SL, Wistar R, Ballou WR, Hollingdale MR, Wirtz RA, Schneider I, Marwoto HA, Hockmeyer WT (1986) Immunity of malaria and naturally acquired antibodies to the circumsporozoite protein of Plasmodium falciparum. N Engl J Med 315: 601–606
Holmberg M, Shenton FC, Franzén L, Janneh K, Snow RW, Pettersson U, Wigzell H, Greenwood BM (1987) Use of a DNA hybridization assay for the detection of Plasmodium falciparum in field trials. Am J Trop Med Hyg 37: 230–234
Hutchinson DBA, Whiteman PD, Farquhar JA (1986) Agranulocytosis associated with Maloprim: a review of cases. Hum Toxicol 5: 221–227
Jackson DV, Marcarelli P, Segal G (1987) Chloroquine-resistant Plasmodium falciparum malaria in West Africa. MMWR 36: 13–14
Jacobs GH, Oduola AM J, Kyle DE, Milhous WK, Martin SK, Aikawa M (1988) Ultrastructural study of the effects of chloroquine and verapamil on Plasmodium falciparum. Am J Trop Med Hyg 39: 15–20
James RF (1985) Malaria treated with emetine or metronidazole. Lancet 2: 498
Jiang J-B, Li G-Q, Guo X-B, Kong YC, Arnold K (1982) Antimalarial activity of mefloquine and qinghaosu. Lancet 2: 285–288
Katongole-Mbidde E, Banura C, Kizito A (1988) Blackwater fever caused by Plasmodium vivax infection in the acquired immune deficiency syndrome. Br Med J 296: 827
Khusmith S, Tharavanij S, Chongsa-Nguan M, Vejvongvarn C, Kasemsuth R (1988) Field applications of an immunoradiometric assay for the detection of Plasmodium falciparum antigen in a population in a malaria endemic area in Thailand. Am J Trop Med Hyg 38: 1–6
Kibukamusoke JW (1984) Quartan malaria nephropathy. In: Kibukamusoke JW (ed) Tropical nephrology. Citforge, Canberra, pp 58–75
Kofi Ekue JM, Simooya OO, Sheth UK, Wernsdorfer WH, Njelesani EK (1985) A double-blind clinical trial of a combination of mefloquine, sulfadoxine and pyrimethamine in symptomatic falciparum malaria. Bull WHO 63: 339–343
Krishna S, Davis TME, Chan PCY, Wells RA, Robson KJH (1988) Ciprofloxacin and malaria. Lancet 1: 1231–1232
Krogstad DJ, Schlesinger PH (1987) The basis of antimalarial action: non-weak base effects of chloroquine on acid vesicle pH. Am J Trop Med Hyg 36: 213–220
Kwiatkowski D, Greenwood BM (1989) Why is malaria fever periodic? A hypothesis. Parasitol Today 5: 264–266
Larrey D, Castot A, Pessayre D, Merigot P, Machayekhy J-P, Feldmann G, Lenoir A, Rueff B, Benhamou J-P (1986) Amodiaquine-induced hepatitis: a report of seven cases. Ann Intern Med 104: 801–803
Laveran A (1881) Un nouveau parasite trouvé dans le sang des malades atteints de fièvre palustre. Bull Soc Med Hop Paris (Mem) 17: 158–164
Lee PS, Lau EYL (1988) Risk of acute non-specific upper respiratory tract infections in healthy men taking dapsone-pyrimethamine for prophylaxis against malaria. Br Med J 296: 893–895
Lim TS (1988) A sensitive malaria immunoperoxidase assay for the detection of Plasmodium falciparum antibody. Am J Trop Med Hyg 38: 255–257
Lobel HO, Campbell CC (1986) Malaria prophylaxis and distribution of drug resistance. In: Strickland GT (ed) Clinics in tropical medicine and communicable diseases, vol 1. Saunders, Philadelphia, pp 225–242
Lobel HO, Campbell CC, Pappaioanou M, Huong AY (1987) Use of prophylaxis for malaria by American travelers to Africa and Haiti. JAMA 257: 2626–2627
Looareesuwan S, Warrell DA, White NJ, Chanthavanich P, Warreil MJ, Chantaratherakitti S, Changswek S, Chongmankongcheep L, Kanchanaranya C (1983) Retinal haemorrhage, a common sign of prognostic significance in cerebral malaria. Am J Trop Med Hyg 32: 911–915
Looareesuwan S, Phillips RE, White NJ, Karbwang J, Benjasurat Y, Attanath P, Warrell DA (1985a) Intravenous amodiaquine and oral amodiaquine/erythromycin in the treatment of chloroquine-resistant falciparum malaria. Lancet 2: 805–808
Looareesuwan S, Phillips RE, White NJ, Kietinun S. Karbwang J, Rackow C, Turner RC, Warrell DA (1985b) Quinine and severe falciparum malaria in late pregnancy. Lancet 2: 4–8
Looareesuwan S, White NJ, Chittamas S, Bunnag D, Harinasuta T (1987) High rate of Plasmodium vivax relapse following treatment of falciparum malaria in Thailand. Lancet 2: 1052–1055
Lumsden WHR (1989) Sweating it out. Br Med J 299: 1341
Malaria Reference Laboratory (1989) Prophylaxis against malaria for travellers from the United Kingdom. Br Med J 299: 1087–1089
Manson P (1900) Experimental proof of the mosquito-malaria theory. Br Med J 2: 949–951
Manson-Bahr PEC, Bell DR (1987) Malaria and babesiosis. In: Manson’s tropical diseases, 19th edn. Bailliere, Tindall, London, 3–51
Martin SK, Oduola AMJ, Milhous WK (1987) Reversal of chloroquine resistance in Plasmodium falciparum by verapamil. Science 235: 899–901
Mashaal H (1986) Malaria in infants and children. In: Clinical malariology 1986. Japan: Southeast Asian Medical Information Center, Japan, 126–40
McLaughlin GL, Breman JG, Collins FH, Schwartz IK, Brandling-Bennett AD, Sulzer AJ, Collins WE, Skinner JC, Ruth JL, Andrysiak PM, Kaseje DCO, Campbell GH (1987) Assessment of a synthetic DNA probe for Plasmodium falciparum in African blood specimens. Am J Trop Med Hyg 37: 27–36
Meek SR, Doberstyn EB, Gaüzere BA, Thanapanich C, Nordlander E, Phuphaisan S (1986) Treatment of falciparum malaria with quinine and tetracycline or combined mefloquine/sulfadoxine/pyrimethamine on the Thai-Kampuchean border. Am J Trop Med Hyg 35: 246–250
Midgley JM, Keter DW, Phillipson JD, Grant S, Warhurst DC (1988) Quinolones and multiresistant Plasmodium falciparum. Lancet 2: 281
Miller KD, Lobel HO, Pappaioanou M, Patchen LC, Churchill FC (1986a) Failures of combined chloroquine and Fansidar prophylaxis in American travellers to East Africa. J Infect Dis 154: 689–691
Miller KD, Lobel HO, Satriale RF, Kuritsky JN, Stern R, Campbell CC (1986b) Severe cutaneous reactions among American travelers using pyrimethamine-sulfadoxine ( Fansidar) for malaria prophylaxis. Am J Trop Med Hyg 35: 451–458
Miller KD, Greenberg AE, Campbell CC (1989) Treatment of severe malaria in the United States with a continuous infusion of quinidine gluconate and exchange transfusion. N Engl J Med 321: 65–70
Miller LH (1986) Research in malaria vaccines. N Eng J Med 315: 640–641
Miller LH (1988) Malaria: effective vaccine for humans? Nature 332: 109–110
Molyneux ME, Looareesuwan S, Menzies IS, Grainger SL, Phillips RE, Wattanagoon Y, Thompson RPH, Warrell DA (1989a) Reduced hepatic blood flow and intestinal malabsorption in severe falciparum malaria. Am J Trop Med Hyg 40: 470–476
Molyneux ME, Taylor TE, Wirima JJ, Harper G (1986b) Effect of rate of infusion of quinine on insulin and glucose responses in Malawian children with falciparum malaria. Br Med J 299: 602–603
Myint PT, Shwe T (1987) A controlled clinical trial of artemether (qinghaosu derivative) versus quinine in complicated and severe falciparum malaria. Trans R Soc Trop Med Hyg 81: 559–561
Nahlen BL, Akintunde A, Alakija T, Ngugen-Dinh P, Ogunbode O, Edungbola LD, Adetoro O, Breman JG (1989) Lack of efficacy of pyrimethamine prophylaxis in pregnant Nigerian women. Lancet 2: 830–834
Neeguaye J (1986) In vivo chloroquine-resistant falciparum malaria in western Africa. Lancet 1: 153
Neftel KA, Woodtly W, Schmid M, Frick PG, Fehr J (1986) Amodiaquine induced agranulocytosis and liver damage. Br Med J 292: 721–723
Nevill CG, Watkins WM, Carter JY, Munafu CG (1988) Comparison of mosquito nets, proguanil hydrochloride, and placebo to prevent malaria. Br Med J 297: 401–403
Nguyen-Dinh P, Greenberg AE, Ryder RW, Mann JM (1987a) Absence of association between HIV seropositivity and Plasmodium falciparum malaria in Kinshasa, Zaire. Abstracts of Third International Conference on AIDS, Washington, DC, p 22
Nguyen-Dinh P, Berzins K, Collins WE, Wahlgren M, Udomsangpetch R, Perlmann P (1987b) Antibodies to PF155, a major antigen of Plasmodium falciparum: longitudinal studies in humans. Am J Trop Med Hyg 37: 501–505
Nickell SP, Scheibel LW, Cole GA (1982) Inhibition by cyclosporin A of rodent malaria in vivo and human malaria in vitro. Infect Immunol 37: 1093–1100
Nussenzweig V, Nussenzweig RS (1986) Development of a sporozoite malaria vaccine. Am J Trop Med Hyg 35: 678–688
Oduola AM J, Milhous WK, Salako LA, Walker O, Desjardins RE (1987) Reduced in-vitro susceptibility to mefloquine in west African isolates of Plasmodium falciparum. Lancet 2: 1304–1305
Onori E, Phan VT (1986) Is Plasmodium falciparum resistance to chloroquine reversible in absence of drug pressure? Lancet 1: 319
Pang LW, Linsomwong N, Boudreau EF, Singharaj P (1987) Doxycycline prophylaxis for falciparum malaria. Lancet 1: 1161–1164
Pappaioanou M, Fishbein DB, Dreesen DW, Schwartz IK, Campbell GH, Sumner JW, Patchen LC, Brown WJ (1986) Antibody response to preexposure human diploid-cell rabies vaccine given concurrently with chloroquine. N Engl J Med 314: 280–284
Patarroyo ME, Amador R, Clavijo P, Moreno A, Guzman F, Romero P, Tascon R, Franco A, Murillo LA, Ponton G, Trujillo G (1988) A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria. Nature 332: 158–161
Peters W (1987a) Chemotherapy and drug resistance in malaria, 2nd edn. Academic Press, Orlando and London, p 1100
Peters W (1987b) How to prevent malaria. Trop Doct 17: 1–3
Peters W, Ekong R, Robinson BL, Warhurst DC, Pan X-Q (1989) Antihistaminic drugs that reverse chloroquine resistance in Plasmodium falciparum. Lancet 2: 334–335
Petersen C, Leech JH (1988) Diagnosis, treatment, and prevention of malaria due to Plasmodium falciparum. In: Leech JH, Sande MA, Root RK (eds) Parasitic infections. Churchill Livingstone, New York and Edinburgh, pp 311–326
Peto TEA, Gilks CF (1986) Strategies for the prevention of malaria in travellers: comparison of drug regimens by means of risk-benefit analysis. Lancet 1: 1256–1261
Phillips RE, Warrell DA, White NJ, Looareesuwan S, Karbwang J (1985) Intravenous quinidine for the treatment of severe falciparum malaria: clinical and pharmacokinetic studies. N Engl J Med 312: 1273–1278
Phillips RE, Looareesuwan S, Warrell DA, Lee SH, Karbwang J, Warrell MJ, White NJ, Swasdichai C, Weatherall DJ (1986a) The importance of anaemia in cerebral and uncomplicated falciparum malaria: role of complications, dyserythropoiesis and iron sequestration. Q J Med 58: 305–323
Phillips RE, Warrell DA, Edwards G, Galagedera Y, Theakstone RDG, Abeysekera DTDJ, Dissanayaka P (1986b) Divided dose intramuscular regimen and single dose subcutaneous regimen for chloroquine: plasma concentrations and toxicity in patients with malaria. Br Med J 293: 13–16
Phillips-Howard PA, Bradley DJ, Blaze M, Hum M (1988) Malaria in Britain: 1977–86. Br Med J 296: 245–248
Phillips-Howard PA, Behrens RH, Dunlop J (1989) Stevens-Johnson Syndrome due to pyrimetha-mine/sulfadoxine during presumptive self-therapy of malaria. Lancet 2: 803–804
Public Health Laboratory Service Malaria Reference Laboratory (1984) Prevention of malaria in pregnancy and early childhood. Br Med J 289: 1296–1297
Reisinger EC, Horstmann RD, Dietrich M (1989) Tolerance of mefloquine alone and in combination with sulfadoxine-pyrimethamine in the prophylaxis of malaria. Trans R Soc Trop Med Hyg 83: 474–477
Rhodes EGH, Ball J, Franklin IM (1986) Amodiaquine induced agranulocytosis: inhibition of colony growth in bone marrow by antimalarial agents. Br Med J 292: 717–718
Rieckmann KH (1987) Tetracycline prophylaxis for malaria. Lancet 2: 507–508
Rieckmann KH, Davis DR, Hutton DC (1989) Plasmodium vivax resistance to chloroquine? Lancet 2: 1183–1184
Rickman LS, Long GW, Hoffman SL (1989a) Rapid diagnosis of malaria. Lancet 1: 1271
Rickman LS, Long GW, Oberst R, Cabanban A, Sangalang R, Smith JI, Chulay JD, Hoffman SL (1989b) Rapid diagnosis of malaria by acridine orange staining of centrifuged parasites. Lancet 1: 68–71
Ristic M (ed) (1988) Babesiosis of domestic animals and man. CRC Press, Boca Raton, Florida, p 255
Rizzo F, Morandi N, Riccio G, Ghiazza G, Caravelli P (1989) Unusual transmission of falciparum malaria in Italy. Lancet 1: 555–556
Rosenberg R, Wirtz RA, Lanar DE, Sattabongkot J, Hall T, Waters AP, Prasittisuk C (1989) Circumsporozoite protein heterogeneity in the human malaria parasite Plasmodium vivax. Science 245: 973–976
Ross R (1897) On some peculiar pigmented cells found in two mosquitos fed on malarial blood. Br Med J 2: 1786–1788
Ross (1898) The role of the mosquito in the evolution of the malarial parasite. Lancet 2: 488–489
Ross R (1988) The great malaria problem and its solution: from the memoirs of Ronald Ross. Keynes Press, London, p 236
Ruebush TK (1984) Babesiosis. In: Strickland GT (ed) Hunter’s tropical medicine, 6th edn. Saunders, Philadelphia, pp 608–611
Saarinen M, Thoren E, Iyambo N, Carlstedt A, Shinyafa L, Fernanda M, Paajanen H, Paajanen K, Indongo I, Rombo L (1987) Mass proguanil prophylaxis. Lancet 1: 985–986
Schofield L, Villaquiran J, Ferreira A, Schellekens H, Nussenzweig R, Nussenzweig V (1987) Interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites. Nature 330: 664–666
Shortt HE, Garnham PCC (1948) Demonstration of a persisting exo-erythrocytic cycle in Plasmodium cynomolgi and its bearing on the production of relapses. Br Med J 1: 1225–1228
Shortt HE, Garnham PCC, Covell G, Shute PG (1948) The pre-erythrocytic stage of human malaria. Plasmodium vivax. Br Med J 1: 547
Shwe T, Myint PT, Myint W, Htut Y, Soe L, Thwe M (1989) Clinical studies on treatment of cerebral malaria with artemether and mefloquine. Trans R Soc Trop Med Hyg 83: 489
Simon F, Bras J le, Gaudebout C, Girard PM (1988) Reduced sensitivity of Plasmodium falciparum to mefloquine in west Africa. Lancet 1: 467–468
Simooya OO, Mwendapole RM, Siziya S, Fleming AF (1988) Relation between falciparum malaria and HIV seropositivity in Ndola, Zambia. Br Med J 297: 30–31
Slutsker L, Breman JG, Campbell CC (1988) Strategies for control of malaria in Africa. Lancet 2: 283
Sowunmi A, Walker O, Salako LA (1989) Pruritus and antimalarial drugs in Africans. Lancet 2: 213
Spencer HC, Strickland GT (1984) Malaria. In: Strickland GT (ed) Hunter’s tropical medicine, 6th edn. Saunders, Philadelphia, pp 516–552
Spielman A, Perrone JB (1989) Rapid diagnosis of malaria. Lancet 1: 727
Stemberger H, Leimer R, Wiedermann G (1984) Tolerability of long-term prophylaxis with Fansidar: a randomized double-blind study in Nigeria. Acta Trop (Basel) 41: 391–399
Stringer C (1988) The dates of Eden. Nature 331: 565–566
Stringer CB, Andrews P (1988) Genetic and fossil evidence for the origin of modern humans. Science 239: 1263–1268
Stuiver PC, Ligthelm RJ, Goud TJLM (1989) Acute psychosis after mefloquine. Lancet 2: 282
Taylor DN, Pitarangsi C, Echeverria P, Diniega BM (1988) Campylobacter enteritis during doxycycline prophylaxis for malaria in Thailand. Lancet 2: 578–579
Thaithong S, Suebsaeng L, Rooney W, Beale GH (1988) Evidence of increased chloroquine sensitivity in Thai isolates of Plasmodium falciparum. Trans R Soc Trop Med Hyg 82: 37–38
Ti T-Y, Jacob E, Wee YJ (1987) The effect of dapsone-pyrimethamine on immunoglobulin concentrations in malaria chemoprophylaxis. Trans R Soc Trop Med Hyg 81: 245–246
Trager W (1989) Erythrocyte knobs and malaria. Nature 340: 352
Udezue EO (1985) Persistence of malarial antibody in Nigerian children born in the UK and its clinical relevance. Trans R Soc Trop Med Hyg 79: 427–429
Udomsangpetch R, Aikawa M, Berzins K, Wahlgren M, Perlmann P (1989) Cytoadherence of knobless Plasmodium falciparum-infected erythrocytes and its inhibition by a human monoclonal antibody. Nature 338: 763–765
Wakeel El S El, Homeida MMA, Ali HM, Geary TG, Jensen JB (1985) Clindamycin for the treatment of falciparum malaria in Sudan. Am J Trop Med Hyg 34: 1065–1068
Warhurst DC (1986a) Antimalarial drugs: mode of action and resistance. J Antimicrob Chemother 18 [suppl B]: 51–59
Warhurst DC (1986b) Antimalarial schizontocides: why a permease is necessary. Parasitol Today 2: 331–334
Warhurst DC (1987) Antimalarial drugs: an update. Drugs 33: 50–65
Warhurst DC (1988) Mechanism of chloroquine resistance in malaria. Parasitol Today 4: 211–213
Warrell DA (1987) Pathophysiology of severe falciparum malaria in man. Parasitology 94: S53–S76
Warrell DA, Looareesuwan S, Warrell MJ, Kasemsarn P, Intaraprasert R, Bunnag D, Harinasuta T (1982) Dexamethasone proves deleterious in cerebral malaria: a double-blind trial in 100 comatose patients. N Engl J Med 306: 313–319
Waters AP, McCutchan TF (1989) Rapid, sensitive diagnosis of malaria based on ribosomal DNA. Lancet 1: 1343–1346
Watkins WM, Branding-Bennett AD, Oloo AJ, Howells RE, Gilles HM, Koech DK (1987) Inadequacy of chlorproguanil 20 mg per week as chemoprophylaxis for falciparum malaria in Kenya. Lancet 1: 125–128
Watkins WM, Oloo JA, Lury JD, Mosoba M, Kariuki D, Mjomba M, Koech DK, Gilles HM (1988) Efficacy of multiple-dose halofantrine in treatment of chloroquine-resistant falciparum malaria in children in Kenya. Lancet 2: 247–250
Wattanagoon Y, Phillips RE, Warreil DA, Silamut K, Looareesuwan S, Nagachinta B, Back DJ (1986) Intramuscular loading dose of quinine for falciparum malaria: pharmacokinetics and toxicity. Br Med J 293: 11–13
Webster HK, Ho M, Looareesuwan S, Pavanand K, Wattanagoon Y, Warreil DA, Hockmeyer WT (1988) Lymphocyte responsiveness to a candidate malaria sporozoite vaccine (R32tet32) of individuals with naturally acquired Plasmodium falciparum malaria. Am J Trop Med Hyg 38: 37–41
Wernsdorfer WH, MacGregor I (eds) (1988) Malaria: principles and practice of malariology (2 vols). Churchill Livingstone, Edinburgh, p 1818
White NJ (1987) Combination treatment for falciparum prophylaxis. Lancet 1: 680–681
White NJ (1988) The treatment of falciparum malaria. Parasitol Today 4: 10–14
White NJ, Looareesuwan S, Warrell DA, Warrell MJ, Chanthavanich P, Bunnag D, Harinasuta T (1983a) Quinine loading dose in cerebral malaria. Am J Trop Med Hyg 32: 1–5
White NJ, Warrell DA, Chanthavanich P, Looareesuwan S, Warrell MJ, Krishna S, Williamson DH, Turner RC (1983b) Severe hypoglycemia and hyperinsulinemia in falciparum malaria. N Engl J Med 309: 61–66
White NJ, Miller KD, Brown J, Marsh K, Greenwood B (1987a) Prognostic value of CSF lactate in cerebral malaria. Lancet 1: 1261
White NJ, Miller KD, Marsh K, Berry CD, Turner RC, Williamson DH, Brown J (1987b) Hypoglycaemia in African children with severe malaria. Lancet 1: 708–711
White NJ, Watt G, Bergqvist Y, Njelesani EK (1987c) Parenteral chloroquine for treating falciparum malaria. J Infect Dis 155: 192–201
Whiteley HE, Everitt JI, Kakoma I, James MA, Ristic M (1987) Pathologic changes associated with fatal Plasmodium falciparum infection in the Bolivian squirrel monkey (Saimiri sciureus boliviensis). Am J Trop Med Hyg 37: 1–8
Whitfield D, Curtis CF, White GB, Targett GAT, Warhurst DC, Bradley DJ (1984) Two cases of falciparum malaria acquired in Britain. Br Med J 289: 1607–1609
Williams A, Lewis DJM (1987) Malaria prophylaxis: postal questionnaire survey of general practitioners in south-east Wales. Br Med J 295: 1449–1452
Win K, Thwe Y, Lwin TT, Win K (1985) Combination of mefloquine with sulfadoxine-pyrimethamine compared with two sulfadoxine-pyrimethamine combinations in malaria chemoprophylaxis. Lancet 2: 694–695
Wirima J, Khoromana C, Molyneux ME, Gilles HM (1988) Clinical trials with halofantrine hydrochloride in Malawi. Lancet 2: 250–252
Wirth DF, Rogers WO, Barker R, Dourado H, Suesebang L, Albuquerque B (1986) Leishmaniasis and malaria: new tools for epidemiologic analysis. Science 234: 975–979
World Health Organisation (1973) Chemotherapy of malaria and resistance to antimalarials. World Health Organisation, Geneva, pp 30–54 (WHO Tech Rep Ser 529 )
World Health Organisation (1987) World malaria situation, 1985. World Health Stat Q 40: 142–170
World Health Organisation (1988) Vaccination certificate requirements and health advice for international travel. WHO, Geneva, p 85
Wright IG, Goodger BV, Clark IA (1988) Immunopathophysiology of Babesia bovis and Plasmodium falciparum infections. Parasitol Today 4: 214–218
Wu L-J, Rabbege JR, Nagasawa H, Jacobs G, Aikawa M (1988) Morphological effects of pyronaridine on malarial parasites. Am J Trop Med Hyg 38: 30–36
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Cook, G.C. (1990). Plasmodium falciparum Infection and the Other Human Malarias. In: Parasitic Disease in Clinical Practice. The Bloomsbury Series in Clinical Science. Springer, London. https://doi.org/10.1007/978-1-4471-1769-8_1
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