Ischaemic Acute Renal Failure in an Intact Animal Model

  • P. J. Ratcliffe
  • Z. H. Endre
  • J. D. Tange
  • J. G. G. Ledingham
Part of the Current Concepts in Critical Care book series (CRITICAL CARE)


Most experimental studies of ischaemic acute renal failure have been devoted to defining the mechanism of loss of excretory function in the damaged kidney and relatively little consideration has been given to the pathophysiological mechanisms leading to the occurrence of ischaemia; yet clinical strategies for prevention of acute renal failure in the Intensive Care Unit might best be drawn from such an understanding. In respect of this we have drawn a parallel with myocardial ischaemia where knowledge of the pathophysiology of the coronary circulation has provided a rational basis for therapeutics. Similar research in nephrology has been hampered by the difficulty of detecting ischaemia in the intact kidney either clinically or experimentally, in contrast with the myocardium where chest pain or changes in the surface electrocardiogram provide markers of ischaemia and permit physiological evaluation and timing of therapeutic intervention. This chapter describes our experience with the use of 31P nuclear magnetic resonance (31P NMR) to detect renal ischaemia in a model of haemorrhagic shock in the rat.


Acute Renal Failure Renal Ischaemia Inulin Clearance Perfuse Kidney Intensive Therapy Unit 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • P. J. Ratcliffe
  • Z. H. Endre
  • J. D. Tange
  • J. G. G. Ledingham

There are no affiliations available

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