Transcriptional Regulation of Acute Phase Response Genes with Emphasis on the Human C-reactive Protein Gene

  • G. Ciliberto
Part of the Argenteuil Symposia book series (ARGENTEUIL)


Acute phase response (APR) is the name given to the complex changes in the concentration of the circulating plasma proteins ensuing from inflammations, infections, stress or traumas. The variation in the level of acute phase reactants is only part of an overall response to local or generalized injury, which includes (i) local events such as vasodilatation; (ii) secondary responses such as neutrophil chemotaxis; and (iii) systemic reactions such as pain, fever, decreased serum zinc and iron concentration, increased serum copper concentration, and other effects, all of which have recently been reviewed (Kushner, 1982; Pepys and Baltz 1983; Koj 1987; Fey and Fuller 1987; Fey and Gauldie 1989).


Acute Phase Response Acute Phase Reactant hep3B Cell Acute Phase Plasma Protein Retinol Binding Protein Gene 
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