Transcriptional Regulation of Acute Phase Response Genes with Emphasis on the Human C-reactive Protein Gene

  • G. Ciliberto
Part of the Argenteuil Symposia book series (ARGENTEUIL)

Abstract

Acute phase response (APR) is the name given to the complex changes in the concentration of the circulating plasma proteins ensuing from inflammations, infections, stress or traumas. The variation in the level of acute phase reactants is only part of an overall response to local or generalized injury, which includes (i) local events such as vasodilatation; (ii) secondary responses such as neutrophil chemotaxis; and (iii) systemic reactions such as pain, fever, decreased serum zinc and iron concentration, increased serum copper concentration, and other effects, all of which have recently been reviewed (Kushner, 1982; Pepys and Baltz 1983; Koj 1987; Fey and Fuller 1987; Fey and Gauldie 1989).

Keywords

Zinc Hepatitis Albumin Leukemia Fractionation 

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References

  1. Ades EW, Hinson A, Chapnis-Celliar C, Arnaud P (1982) Modulation of the immuno response by plasma protease inhibitor. Scand J Immunol 15: 109–113PubMedCrossRefGoogle Scholar
  2. Andus T, Heinrich PC, Bauer J, et al. (1987) Discrimination of hepatocyte-stimulating activity from human recombinant tumor necrosis factor a. Eur J Immunol 17: 1175–1197CrossRefGoogle Scholar
  3. Arcone R, Gualandi G, Ciliberto G (1988) Identification of sequences responsible for acute-phase induction of human C-reactive protein. Nucl Acids Res 16: 3195–3207PubMedCrossRefGoogle Scholar
  4. Bauer J, Birmelin M, Northoff GH, et al. (1984) Induction of rat o2-macroglobulin in vivo and in hepatocyte culture: synergistic action of glucocorticoids and a Kupffer cell derived factor. FEBS Lett 177: 89–94PubMedCrossRefGoogle Scholar
  5. Baumann H, Maquat LE (1986) Localization of DNA sequences involved in dexamethasone dependent expression of the rat arl-acid glycoprotein gene. Mol Cell Biol 6: 2551–2561PubMedGoogle Scholar
  6. Baumann H, Firestone CL, Burgess TL, et al. (1983a) Dexamethasone regulation of arl-acid glycoprotein and other acute phase reactants in rat liver and hepatoma cells. J Biol Chem 258: 563–570PubMedGoogle Scholar
  7. Baumann H, Jahreis GP, Gaines KC (1983b) Synthesis and regulation of acute phase plasma proteins in primary cultures of mouse hepatocytes. J Cell Biol 97: 866–876PubMedCrossRefGoogle Scholar
  8. Baumann H, Jahreis GP, Sauder DN, et al. (1984) Human keratinocytes and monocytes release factors which regulate the synthesis of major acute phase plasma proteins in hepatic cells from man, rat and mouse. J Biol Chem 259: 7331–7342PubMedGoogle Scholar
  9. Baumann H, Hill RE, Sauder DN, et al. (1986) Regulation of major acute phase plasma proteins by hepatocyte stimulating factors of human squamous carcinoma cells. J Cell Biol 102: 370–383PubMedCrossRefGoogle Scholar
  10. Baumann H, Onorato V, Gauldie J, et al. (1987a) Distinct sets of acute phase plasma proteins are stimulated by separate human hepatocyte-stimulatory factors and monokines in rat hepatoma cells. J Biol Chem 262: 9756–9768PubMedGoogle Scholar
  11. Baumann H, Richards C, Gauldie J (1987b) Interaction among hepatocyte-stimulating factor, interleukin 1 and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2). J Immunol 139: 4122–4128PubMedGoogle Scholar
  12. Billiau A (1987) Interferon-j82 as a promoter of growth and differentiation of B cells. Immunol Today 8: 84–87CrossRefGoogle Scholar
  13. Birch H, Schreiber G (1986) Transcriptional regulation of plasma protein synthesis during inflammation. J Biol Chem 261: 8077–8080PubMedGoogle Scholar
  14. Bohmann D, Bos TJ, Nishimura T, et al. (1987) Human proto-oncogene c-jun encodes a protein with antigenic and enhancer binding properties of transcription factor AP-1. Science 238: 1386–1392PubMedCrossRefGoogle Scholar
  15. Bowmann BH, Kurowsky (1982) Haptoglobin: the evolutionary product of duplication, unequal crossing over and point mutation. Adv Hum Genet 12: 189–261Google Scholar
  16. Catell JV, Gomez-Lechon MJ, David M, et al. (1988) Recombinant human interleukin-6 (IL-6/BSF- 2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes. FEBS Lett 232: 347–350CrossRefGoogle Scholar
  17. Cerenghini S, Raymondjean M, Carranca AG, et al. (1987) Factors involved in control of tissue-specific expression of albumin gene. Cell 50: 627–638CrossRefGoogle Scholar
  18. Cerenghini S, Blumenfeld M, Yaniv M (1988) A liver specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells. Genes Devel 2: 957–974CrossRefGoogle Scholar
  19. Ciliberto G, Dente L, Cortese R (1985) Cell-specific expression of a transfected human al-antitrypsin gene. Cell 41: 531–540PubMedCrossRefGoogle Scholar
  20. Ciliberto G, Pizza MG, Arcone R, et al. (1987a) DNA sequence of a pseudogene for human C-reactive protein. Nucl Acids Res 14: 5895CrossRefGoogle Scholar
  21. Ciliberto G, Arcone R, Wagner EF, et al. (1987b) Inducible and tissue-specific expression of human C-reactive protein in transgenic mice. EMBO J 6: 4017–4022PubMedGoogle Scholar
  22. Colantuoni V, Pirozzi A, Blance C, et al. (1987) Negative control of liver-specific gene expression: cloned human retinol-binding protein gene is repressed in HeLa cells. EMBO J 6: 631–636PubMedGoogle Scholar
  23. Costa RH, Eseng L, Darnell JE Jr (1986) Transcriptional control of the mouse prealbumin (transthyretin) gene: both promoter sequences and a distinct enhancer are cell specific. Mol Cell Biol 6: 4697–4707PubMedGoogle Scholar
  24. Costa RH, Grayson DR, Xanthopulos KG, et al. (1988) A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, al-antitrypsin, albumin and simian virus 40 genes. Proc Natl Acad Sci USA 85: 3840–3844PubMedCrossRefGoogle Scholar
  25. Courtois G, Morgan JG, Campbell LA, et al. (1987) Interaction of a liver-specific nuclear factor with the fibrinogen and al-antitrypsin promoters. Science 238: 688–692PubMedCrossRefGoogle Scholar
  26. Darlington GJ, Wilson DR, Lachmann LB (1986) Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro. J Cell Biol 103: 787–793PubMedCrossRefGoogle Scholar
  27. Dente L, Pizza MG, Metzpalu A, et al. (1987) Structure and expression of the genes coding for human arl-acid glycoprotein. EMBO J 6: 2289–2296PubMedGoogle Scholar
  28. Dente L, Tripodi M, Riither U, et al. (1988) Expression of cloned human AGP genes in cultured cell lines and in transgenic mice. Genes Dev 2: 259–266PubMedCrossRefGoogle Scholar
  29. Deschatrette J, Weiss MC (1974) Characterization of differentiated and dedifferentiated clones from a rat hepatoma. Biochemie 56: 1603–1611CrossRefGoogle Scholar
  30. Deschatrette J, Moore EE, Dubois M, et al. (1979) Dedifferentiated variants of a rat hepatoma: analysis by cell hybridization. Somatic Cell Genet 5: 697–718PubMedCrossRefGoogle Scholar
  31. Deschatrette J, Moore EE, Dubois M, et al. (1980) Dedifferentiated variants of a rat hepatoma: reversion analysis. Cell 19: 1043–1051PubMedCrossRefGoogle Scholar
  32. De Simone V, Cortese R (1988) The transcriptional regulation of liver specific gene expression. In: McLean N (ed) Oxford surveys on eukaryotic genes, vol 5. Oxford University Press, Oxford, pp 51–90Google Scholar
  33. De Simone V, Ciliberto G, Hardon E, et al. (1987) Cis- and trans-acting elements responsible for the cell-specific expression of the human al-antitrypsin gene. EMBO J 6: 2759–2766PubMedGoogle Scholar
  34. D’Onofrio C, Colantuoni V, Cortese R (1985) Structure and cell-specific expression of a cloned human retinol binding protein gene: the 5′-flanking region contains hepatoma specific transcriptional signals. EMBO J 4: 1981–1989PubMedGoogle Scholar
  35. Esnard F, Gauthier F (1980) Purification and physiochemical characterization of a new rat plasma proteinase inhibitor, arl-inhibitor III. Biochim Biophys Acta 614: 553–563PubMedGoogle Scholar
  36. Evans E, Courtois GM, Kilian PL, Fuller GM, Crabtree GR (1987) Induction of fibrinogen and a subset of acute phase response genes involves a novel monokine which is mimicked by phorbol esters. J Biol Chem 262: 10850–10854PubMedGoogle Scholar
  37. Fey GH, Fuller GM (1987) Regulation of acute phase gene expression by inflammatory mediators. Mol Biol Med 4: 323–338PubMedGoogle Scholar
  38. Fey GH, Gauldie J (1989) The acute phase of the liver in inflammation. In: Popper M, Schaffner F (eds) Progress in liver diseases, vol 9. WB Saunders, Philadelphia (in press)Google Scholar
  39. Fuller GM, Bunzel RJ, Woloski BM, et al. (1987) Isolation of hepatocyte stimulating factor from human monocytes. Biophys Biochem Res Comm 144: 1003–1009CrossRefGoogle Scholar
  40. Furie B, Furie BC (1988) The molecular basis of blood coagulation. Cell 53: 505–518PubMedCrossRefGoogle Scholar
  41. Gauldie J, Richards C, Harnish D, et al. (1987) Interferon ß2/BSF2 shares identity with monocyte derived hepatocyte stimulating factor (HSF) and regulates the major acute phase protein response in liver cells. Proc Natl Acad Sci USA 84: 7251–7255PubMedCrossRefGoogle Scholar
  42. Gehring MR, Shiels BR, Northemann W, et al. (1987) Sequence of rat a2-macroglobulin and acute phase control of its messenger RNA. J Biol Chem 262: 446–454PubMedGoogle Scholar
  43. Godbout R, Ingram R, Thilghman SM (1986) Multiple regulatory elements in the intergenic region between the ar-fetoprotein and albumin genes. Mol Cell Biol 6: 477–487PubMedGoogle Scholar
  44. Goldman ND, Liu T-Y (1987) Biosynthesis of human C-reactive protein in cultured hepatoma cells is induced by a monocyte factor(s) other than interleukin 1. J Biol Chem 262: 2363–2368PubMedGoogle Scholar
  45. Gordon AH (1976) The ar-macroglobulins of rat serum. Biochem J 159: 643–650PubMedGoogle Scholar
  46. Gorski K, Carneiro M, Schibier U (1986) Tissue-specific in vitro transcription from the mouse albumin promoter. Cell 47: 767–776PubMedCrossRefGoogle Scholar
  47. Grayson DR, Costa RH, Xanthopoulos KG, et al. (1988a) A cell-specific enhancer of the mouse arl-antitrypsin gene has multiple functional regions and corresponding protein binding sites. Mol Cell Biol 8: 1055–1066PubMedGoogle Scholar
  48. Grayson DR, Costa RH, Xanthopoulos KG, et al. (1988b) One factor recognizes the liver-specific enhancers in arl-antitrypsin and transthyretin genes. Science 239:786–788Google Scholar
  49. Gross V, Andus T, Tran-Thi TA, et al. (1984) Induction of acute phase proteins by dexamethasone in primary rat hepatocyte cultures. Exp Cell Res 151: 46–54PubMedCrossRefGoogle Scholar
  50. Hardon EM, Frain M, Paonessa G, et al. (1988) Two distinct factors interact with the promoter regions of several liver-specific genes. EMBO J 7: 1711–1719PubMedGoogle Scholar
  51. Heard JM, Herbomel P, Ott M-O, et al. (1987) Determinants of rat albumin promoter tissue specificity analyzed by an improved transient expression system. Mol Cell Biol 7: 2425–2434PubMedGoogle Scholar
  52. Hudig D, Haverty T, Fulcher C, et al. (1981) Inhibition of human natural cytoxicity by macromolecular antiproteases. J Immunol 126: 1569–1574PubMedGoogle Scholar
  53. James K (1980) a2-macroglobin and its possible importance in the immune system. Trends Biochem Sci 5:43–47Google Scholar
  54. Jones NC, Rigby PW, Ziff EB (1988) 7>flws-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses. Genes Dev 2: 267–281Google Scholar
  55. Kampschmidt RF, Mesecher M (1985) Interleukin-1 from P388D: effects upon neutrophils, plasma iron, and fibrinogen in rats, mice and rabbits. Proc Soc Exp Biol Med 179: 197–200PubMedGoogle Scholar
  56. Kishimoto T, Hirano T (1988) Molecular regulation of lymphocyte response. Ann Rev Immunol 6: 485–512CrossRefGoogle Scholar
  57. Klein ES, Reinke S, Feigelsohn P, et al. (1987) Glucocorticoid-regulated expression from the 5′ flanking region of the rat arl-acid glycoprotein gene. J Biol Chem 262: 523–532Google Scholar
  58. Knowles BB, Howe CC, Aden DP (1980) Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 209: 497–499PubMedCrossRefGoogle Scholar
  59. Koj A (1987) Biological functions of acute phase proteins and the cytokines involved in their induced synthesis. In: Reutter W (ed) Modulation of liver cell expression. MTP Press, Lancaster, pp 331–342 (Falk symposium no. 43 )Google Scholar
  60. Koj A, Gauldie J, Regoeczi E, et al. (1984) The acute phase response of cultured rat hepatocytes. Biochem J 22: 550–514Google Scholar
  61. Kulkarni AB, Reinke R, Feigelson P (1985) Acute phase mediators and glucorticoids elevate arl-acid glycoprotein gene transcription. J Biol Chem 260: 15386–15389PubMedGoogle Scholar
  62. Kushner I (1982) The phenomenon of the acute phase response. Ann NY Acad Sci 389: 39–48PubMedCrossRefGoogle Scholar
  63. Landschultz WH, Johnson F, Adashi EY, et al. (1988) Isolation of a recombinant copy of the gene encoding C/EBP. Genes Dev 2: 786–800CrossRefGoogle Scholar
  64. Lei K-J, Liu T, Zon G, et al. (1985) Genomic DNA sequence for human C-reactive protein. J Biol Chem 260: 13377–13383PubMedGoogle Scholar
  65. Li Y, Shen R-F, Tsai SY, et al. (1988) Multiple hepatic trans-acting factors are required for in vitro transcription of the human al-antitrypsin gene. Mol Cell Biol 83: 4362–4369Google Scholar
  66. Lichtsteiner S, Wuarin J, Schibier U (1987) The interplay of DNA-binding proteins on the promoter of the mouse albumin gene. Cell 51: 963–973PubMedCrossRefGoogle Scholar
  67. Lonbera-Holm K, Reed D, Roberts RC, et al. (1987) Three high molecular weight proteinase inhibitors of rat plasma. J Biol Chem 252: 438–445Google Scholar
  68. Lowell CA, Stearman RS, Morrow JF (1986) Transcriptional regulation of serum amyloid A gene expression. J Biol Chem 261: 8453–8461PubMedGoogle Scholar
  69. MacLeod CM, Avery OT (1941) The occurrence during acute infections of a protein not normally present in the blood. J Exp Med 73: 191–200PubMedCrossRefGoogle Scholar
  70. Mevel-Ninio M, Weiss MC (1981) Immunofluorescence analysis of the time-course of extinction, reexpression and activation of albumin production in rat hepatoma-mouse fibroblast heterokaryons and hybrids. J Cell Biol 10: 339–350CrossRefGoogle Scholar
  71. Monaci P, Nicosia A, Cortese R (1988) Characterization of the cis- and trans-acting elements necessary for the liver-specific transcription in vitro of the human al-antitrypsin promoter. EMBO J 7: 2075–2087PubMedGoogle Scholar
  72. Morrone G, Ciliberto G, Oliviero S, et al. (1988) Recombinant interleukin 6 regulates the transcriptional activation of a set of human acute phase genes. J Biol Chem 263: 12554–12558PubMedGoogle Scholar
  73. Müller-Eberhard V, Liem HH (1974) In: Allison AC (ed), Structure and function of plasma proteins, vol 1. Plenum Press, London, pp 35–53Google Scholar
  74. Nathan CF (1987) Secretory products of macrophages. J Clin Invest 79: 319–326PubMedCrossRefGoogle Scholar
  75. Northemann W, Ueberberg H, Fey GH (1988a) Cordinated regulation of the rat a2-macroglobulin gene by inflammatory signals and glucocorticoids. Mol Gen (Life Sci Adv) 7: 7–10Google Scholar
  76. Northemann W, Shiels BR, Braciak TA, et al. (1988b) Structure and negative transcriptional regulation by glucocorticoids of the acute phase rat al-inhibitor III gene. Biochemistry (in press)Google Scholar
  77. Northoff H, Andus T, Tran-Thi TA, et al. (1987) The inflammation mediators interleukin 1 and hepatocyte stimulating factor are differently regulated in human monocytes. 17: 707–711Google Scholar
  78. Oliviero S, Morrone G, Cortese R (1987) The human haptoglobin gene: transcriptional regulation during development and acute phase induction. EMBO J 6: 1905–1912PubMedGoogle Scholar
  79. Ott M-O, Sperling L, Herbomel P, et al. (1984) Tissue-specific expression is conferred by a sequence from the 5′ end of the rat albumin gene. EMBO J 3: 2505–2510PubMedGoogle Scholar
  80. Paonessa G, Gounari F, Frank R, et al. (1988) Purification of a NFl-like DNA binding protein from rat liver and cloning of the corresponding cDNA. EMBO J 10: 3115–3123Google Scholar
  81. Pepys MB, Baltz ML (1983) Acute phase proteins with special reference to C-reactive protein and related proteins (pentraxins) and serum amyloid A protein. Adv Immunol 34: 141–212PubMedCrossRefGoogle Scholar
  82. Perlmutter DH, Goldberger G, Dinarello CA, et al. (1986a) Regulation of class III major histocompatibility complex gene products by interleukin-1. Science 232: 850–652PubMedCrossRefGoogle Scholar
  83. Perlmutter DH, Dinarello CA, Punsai PI, et al. (1986b) Cachectin/tumour necrosis factor regulates hepatic acute-phase gene expression. J Clin Invest 78: 1349–1353PubMedCrossRefGoogle Scholar
  84. Pinkert CA, Ornitz DM, Brinster RL, et al. (1987) An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev 1: 268–276PubMedCrossRefGoogle Scholar
  85. Prowse KR, Baumann H (1988) Hepatocyte-stimulating factor, beta 2 interferon and interleukin 1 enhance expression of the rat arl-acid glycoprotein gene via a distal upstream regulatory region. Mol Cell Biol 8: 42–51PubMedGoogle Scholar
  86. Putnam FW (ed) (1975). The plasma proteins: structure, function and genetic control. Academic Press, New YorkGoogle Scholar
  87. Ramadori G, Sipe JD, Mizel SB, et al. (1985) Pretranslation modulation of acute-phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified IL-1. J Exp Med 162: 930–942PubMedCrossRefGoogle Scholar
  88. Robey FA, Jones KD (1986) C-reactive protein, chromatin, immunomodulation of the acute phase response. In: Peeters H (ed), Protides of the biological fluids, vol 34. Pergamon Press, Oxford, pp 267–270Google Scholar
  89. Robey FA, Jones KD, Tanaka T, et al. (1984) Binding of C-reactive protein to chromatin and nucleosome core particles. J Biol Chem 259: 7311–7316PubMedGoogle Scholar
  90. Rüther U, Tripodi M, Cortese R, et al. (1987) The human al-antitrypsin gene is efficiently expressed from two tissue-specific promoters in transgenic mice. Nucl Acids Res 15: 7519–7529PubMedCrossRefGoogle Scholar
  91. Santoro C, Mermod N, Andrews PC, et al. (1988) A family of human CCAAT-box-binding proteins active in transcription and DNA replication and expression of multiple cDNAs. Nature 334: 218–224PubMedCrossRefGoogle Scholar
  92. Sehgal PB, May LT, Tamm I, et al. (1987) Human)82 interferon and B cell differentiation factor BSF-2 are identical. Science 235: 731–732PubMedCrossRefGoogle Scholar
  93. Shen R-F, Clift SM,, de Mayo JL et al. (1987) Tissue-specific expression of the human al-antitrypsin gene is controlled by multiple cis-regulatory sequences. Nucl Acids Res 15: 8399–8415PubMedCrossRefGoogle Scholar
  94. Shen R-F, Clift SM, De Mayo JL, et al. (1988) Tissue-specific regulation of human al-antitrypsin gene expression in transgenic mice. DNA (in press)Google Scholar
  95. Sifers RN, Carlson JA, Clift SM, et al. (1987) Tissue-specific expression of the human al-antitrypsin gene in transgenic mice. Nucl Acids Res 15: 1459–1475PubMedCrossRefGoogle Scholar
  96. Sims JE, March CE, Losman D, et al. (1988) cDNA expression cloning of the IL1 receptor, a member of the immunoglobulin superfamily. Science 241: 585–589Google Scholar
  97. Sipe JD, Vogel SN, Sztein MB, et al. (1982) Interleukin 1 in acute phase. Serum amyloid A (SAA) and serum amyloid P (SAP) biosynthesis. Ann NY Acad Sci 389: 137–150PubMedCrossRefGoogle Scholar
  98. Yamasaki K, Taga T, Hirata Y, et al. (1988) Cloning and expression of the human interleukin 6 (BSF/IFN/32) receptor. Science 241: 825–828PubMedCrossRefGoogle Scholar
  99. Whitehead AS, Bruns GAP, Markham AF, et al. (1983) Isolation of human C-reactive protein complementary DNA and localization of the gene to chromosome 1. Science 221: 69–71PubMedCrossRefGoogle Scholar
  100. Woloski BM, Fuller GM (1985) Identification and partial characterization of hepatocyte stimulating factor leukemia cell lines: comparison with interleukin-1. Proc Natl Acad Sci USA 82: 1443–1447PubMedCrossRefGoogle Scholar
  101. Wong GG, Clark SC (1988). Multiple actions of interleukin 6 within a cytokine network. Immunol Today 9: 137–139PubMedCrossRefGoogle Scholar
  102. Woo P, Korenberg JR, Whitehead AS (1985) Characterization of genomic and complementary DNA sequence of human C-reactive protein, and comparison with the complementary DNA sequence of serum amyloid P component. J Biol Chem 260: 13384–13388PubMedGoogle Scholar
  103. Wu LC, Morley BJ, Campbell RD (1987) Cell-specific expression of the human complement factor B gene: evidence for the role of two distinct 5′ flanking elements. Cell 48: 331–342PubMedCrossRefGoogle Scholar

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  • G. Ciliberto

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