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Acute Phase Proteins in the Acute Phase Response pp 123–136Cite as

The Three Dimensional Structure of SAP

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Part of the book series: Argenteuil Symposia ((ARGENTEUIL))

Abstract

Serum amyloid P (SAP) component and C-reactive protein (CRP) are members of a closely related family of pentameric or decameric proteins called pentraxins which are involved in amyloidosis and the acute phase response (Pepys and Baltz 1983). Although CRP was crystallised in 1947 (McCarty 1947), no detailed three dimensional structural information has been obtained by X-ray analysis. However, several recent reports of CRP (DeLucas et al. 1987) and SAP (Wood et al. 1988) crystals have demonstrated that this is now a realistic objective. In this paper we review progress made on the X-ray analysis in our laboratory, and describe for the first time preliminary, medium resolution electron density maps of a pentameric form of SAP.

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Authors
  1. H. E. White
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  2. B. P. O’Hara
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  3. G. Oliva
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  4. T. L. Blundell
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  5. M. B. Pepys
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  6. S. P. Wood
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Editor information

Editors and Affiliations

  1. Immunological Medicine Unit, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, W12 0NN, London, UK

    M. B. Pepys MA, MD, PhD, FRCP, MCRPath

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© 1989 Springer-Verlag London Limited

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White, H.E., O’Hara, B.P., Oliva, G., Blundell, T.L., Pepys, M.B., Wood, S.P. (1989). The Three Dimensional Structure of SAP. In: Pepys, M.B. (eds) Acute Phase Proteins in the Acute Phase Response. Argenteuil Symposia. Springer, London. https://doi.org/10.1007/978-1-4471-1739-1_10

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  • DOI: https://doi.org/10.1007/978-1-4471-1739-1_10

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1741-4

  • Online ISBN: 978-1-4471-1739-1

  • eBook Packages: Springer Book Archive

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