Pathology of Radiation Injury

  • N. Y. Haboubi
  • P. S. Hasleton

Abstract

Irradiation is widely used in the treatment of some malignant tumours. It has become the therapy of choice in certain circumstances where surgery and/or chemotherapy have failed to produce good results. With increasing use, we have become more aware of the complications and potential hazards of radiotherapy. This chapter aims to describe the pathological changes after radiation to the bowel and the urogenital tracts. Both systems are affected due to their inclusion in the pelvic irradiation field. The commonest pelvic tumour requiring radiotherapy arises within the uterine cervix but tumours of the uterine body, ovaries, vagina, bladder, prostate and rectum are being increasingly treated by radiotherapy.

Keywords

Permeability Adenocarcinoma Tuberculosis Oncol Dehydration 

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References

  1. Berthrong M (1986) Pathological changes secondary to radiation. World J Surg 10:155–170PubMedCrossRefGoogle Scholar
  2. Berthrong M, Fajardo LF (1981) Radiation in surgical pathology, part 2, alimentary tract. Am J Surg Pathol 5:153–178PubMedCrossRefGoogle Scholar
  3. Black WC, Gomez LS, Yukas JM, Kligerman MM (1980) Quantitation of the late effects of X-irradiation on the large intestine. Cancer 45:444–451PubMedCrossRefGoogle Scholar
  4. Carr ND, Farragher EB, Hasleton PS (1988) Quantitative study of internal, longitudinal smooth muscle in human small mesenteric arteries. Acta Anat 32:69–73Google Scholar
  5. Crawford T (1977) Blood and lymphatic vessels. In: Anderson WAA, Kissane JM (eds) Pathology, 7th edn. Mosby, St Louis, pp 879–921Google Scholar
  6. DeCosse JJ, Rhodes RS, Wentz WB, Reagan JW, Dworken HJ, Holden WD (1969) The natural history and management of radiation-induced injury of the gastrointestinal tract. Ann Surg 170:369–384PubMedCrossRefGoogle Scholar
  7. Dewit L, Oussoren Y (1987) Vascular injury in the mouse rectum after irradiation and cisdiammine-dichloroplatinum. Br J Radiol 60:1037–1040PubMedCrossRefGoogle Scholar
  8. Fajardo LF (1982) The pathology of radiation injury. Masson Publishing USA, Inc, New York, p 6Google Scholar
  9. Fajardo LF, Stewart JR (1973) Pathogenesis of radiation-induced myocardial fibrosis. Lab Invest 29:244–257PubMedGoogle Scholar
  10. Fonkalsrud EW, Sanchez M, Zerbuarel R, Mahoney A (1977) Serial changes in arterial structure following radiation therapy. Surg Gynecol Obstet 145:395–400PubMedGoogle Scholar
  11. Gardiner GW, McAulieffe N, Murray D (1984) Colitis cystica profunda occurring in a radiation-induced colonic stricture. Hum Pathol 15:295–298PubMedCrossRefGoogle Scholar
  12. Gelfand MD, Tepper M, Katz L, Binder H, Yesner R, Flouch M (1968) Acute radiation proctitis. Gastroenterology 54:401–411PubMedGoogle Scholar
  13. Haboubi NY, Schofield PF, Rowland P (1988) The light and electron microscopic features of early and late phase radiation-induced proctitis. Am J Gastroenterol 3:1140–1144Google Scholar
  14. Hasleton PS, Carr N, Schofield PF (1985) Vascular changes in radiation bowel disease. Histopath-ology 9:517–534CrossRefGoogle Scholar
  15. Neemann MP, Limas C (1986) Transitional cell carcinoma in the urinary bladder. Effect of pre-operative radiation on morphology. Cancer 58:2758–2763CrossRefGoogle Scholar
  16. O’Brien PH, Junrette JH, Garner AJ (1987) Radiation enteritis. Ann Surg 53:501–504Google Scholar
  17. Pugh RCB (1977) Lower urinary tract. In: Anderson WAA, Kissane JM (eds) Pathology, 7th edn. Mosby, St Louis, pp 977–998Google Scholar
  18. Rubin P (1984) Late effects of chemotherapy and radiation therapy, a new hypothesis. Int J Radiat Oncol Biol Phys 10:5–34PubMedGoogle Scholar
  19. Scarpelli DG, Chiga M (1977) Characteristic cell injury and errors of metabolism. In: Anderson WAA, Kissane JM (eds) Pathology, 7th edn. Mosby, St Louis, pp 90–147Google Scholar
  20. Schofield PF (1987) Radiation damage to the bowel. In: Taylor I (ed) Progress in surgery, vol. 2. Churchill Livingstone, Edinburgh London, pp 142–156Google Scholar
  21. Trier JS, Browning TH (1966) Morphological response of the mucosa of human small intestine to X-ray exposure. J Clin Invest 45:194–204PubMedCrossRefGoogle Scholar
  22. Villasanta U (1972) Complications of radiotherapy for carcinoma of the uterine cervix. Am J Obstet Gynecol 114:717–726PubMedGoogle Scholar
  23. Wallace DM (1959) Tumours of the bladder. Livingstone, Edinburgh London, p 280Google Scholar
  24. Williamson RCN (1978) Intestinal adaptation: structural, functional and cytokinetic changes. N Engl J Med 298:1393–1402PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • N. Y. Haboubi
  • P. S. Hasleton

There are no affiliations available

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