The Management of the Side Effects of Cytotoxic Drugs

  • T. J. Priestman

Abstract

The ability of cytotoxic drugs to cure malignant disease is limited by two factors, drug resistance of tumour cells and the toxic effects of treatment on normal tissues. A number of techniques have been developed in an attempt to overcome the problems created by drug toxicity, in the hope of allowing higher doses of cytotoxics to be given, thereby increasing the chance of cure. Before considering the prevention and management of specific side effects it is important to realise that the very considerable hazards involved in the use of cytotoxic agents may be minimised by taking a few routine precautions.

Keywords

Toxicity Dexamethasone Doxorubicin Cyclophosphamide Thrombocytopenia 

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References

  1. Prophylactic granulocyte transfusion during chemotherapy of acute nonlymphocytic leukemia. Winston DJ, Ho WG, Gale RP (1981) Annals of Internal Medicine, 94: 616–622PubMedGoogle Scholar
  2. Platelet transfusion therapy. Anonymous (1987) Lancet, 2: 490–491Google Scholar
  3. Broad spectrum antibacterial regimes for the seriously ill. Anonymous (1986) Drug and Therapeutics Bulletin, 24: 33–36Google Scholar
  4. The use of anti-emetics during cancer chemotherapy. Allan SG (1986) Cancer Topics, 5: 126–127Google Scholar
  5. Antiemetic therapy and cancer chemotherapy. Gralla RJ in Fundamentals of Cancer Chemotherapy (Eds. Hellman K, Carter SK) McGraw Hill, New York, 1987, pp 387–396Google Scholar
  6. Domperidone: an alternative to metoclopramide. Anonymous (1988) Drug and Therapeutic Bulletin, 26: 59–60Google Scholar
  7. Etiology and treatment of chemotherapeutic agent extravasation injuries: a review. Rudolph R, Larson DL (1987) Journal of Clinical Oncology, 5:116–126Google Scholar
  8. Therapy of local toxicities caused by extravasation of cancer chemotherapeutic drugs. Ignoffo RJ, Friedman MA (1980) Cancer Treatment Reviews, 7: 17–27PubMedCrossRefGoogle Scholar
  9. Mesna - a short review. Shaw IC, Graham MI (1987) Cancer Treatment Reviews, 14: 67–86.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • T. J. Priestman
    • 1
  1. 1.Queen Elizabeth HospitalEdgbaston, BirminghamUK

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