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Pathology and Pathogenesis

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Herpes Simplex Virus

Part of the book series: The Bloomsbury Series in Clinical Science ((BLOOMSBURY))

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Abstract

There are two separate and distinct outcomes following cellular infection with herpes simplex: (1) a productive infection (see Chap. 1) with active viral replication, occurring first in epithelial cells and resulting in ultimate cell death; and (2) a non-productive (or latent) infection, occurring in nerve cells (see Chap. 2). The productive infection causes most of the clinical symptoms and signs associated with herpes, from the most trivial cutaneous lesions to widespread disseminated illness seen in immunocompromised patients (see Chaps. 4 and 5). The latent (non-productive) infection does not itself cause any pathological changes but is responsible for the reactivation characteristic of HSV infections.

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References

  • Agha FP, Lee HH, Nostrant TT (1986) Herpetic esophagitis: a diagnostic challenge in immunocompromised patients. Am J Gastroenterol 181: 246–253

    Google Scholar 

  • Altshuler G (1974) Pathogenesis of congenital herpes virus infection. Case report including a description of the placenta. Am J Dis Child 127: 427–429

    PubMed  CAS  Google Scholar 

  • Anonymous (1979) Weekly clinicopathological conference case 44. N Engl J Med 301: 987–994

    Article  Google Scholar 

  • Arje SL, Austin CA, Sanchez AF (1955) Herpetic hepatitis of the newborn. Obstet Gynecol 6: 169–173

    PubMed  CAS  Google Scholar 

  • Barker JNWN, Algere VA, MacDonald DM (1988) Surface bound immunoglobin E on antigenpresenting cells in cutaneous tissue of atopic dermatitis. J Invest Dermatol 90: 117–121

    CAS  Google Scholar 

  • Bowman CA, Woolley PD, Kinghorn GR (1988) Herpes simplex virus neonatal encephalitis. Lancet is 646

    Google Scholar 

  • Carmichael LE, Barnes FD, Percy DH (1970) Temperature as a factor in resistance of young puppies to canine herpesvirus. J Infect Dis 120: 669–678

    Article  Google Scholar 

  • Chase RA, Pottage JC, Haber MH, Kistler G, Jensen D, Levin S (1987) Herpes simplex viral hepatitis in adults: two case reports and review of the literature. Rev Infect Dis 9: 329–333

    Article  PubMed  CAS  Google Scholar 

  • Ching C, Lopez C (1979) Natural killing of herpes simpex virus type 1-infected target cells. Normal human responses and influence of antiviral antibody. Infect Immun 26: 49–56

    Google Scholar 

  • Corey L, Adams HG, Brown ZA, Holmes KK (1983) Genital herpes simplex virus infections: clinical manifestations, course and complications. Ann Intern Med 98: 958–972

    PubMed  CAS  Google Scholar 

  • Corey L, Whitley RJ, Stone EF, Mohan K (1988) Difference between herpes simplex virus type 1 and type 2 neonatal encephalitis in neurological outcome. Lancet is 1–4

    Google Scholar 

  • Cowdry EV (1934) The problem of intranuclear inclusions in viral disease. Arch Pathol Lab Med 18: 527–542

    Google Scholar 

  • Craig C, Nahmias AJ (1973) Different patterns of neurologic involvement with herpes simplex virus types 1 and 2: isolation of herpes simplex virus type 2 from the buffy coat of 2 adults with meningitis. J Infect Dis 127: 365–372

    Article  PubMed  CAS  Google Scholar 

  • Culbertson WW, Blumenkrantz MS, Haines H, Gass DM, Mitchell KB, Norton EWD (1982) The acute retinal necrosis syndrome. Ophthalmology 89: 1317–1325

    PubMed  CAS  Google Scholar 

  • Cunningham AL, Turner RR, Miller AC, Para MF, Merigan TC (1985) Evaluation of recurrent herpes simplex lesions - an immunohistological study. J Clin Invest 75: 226–233

    Article  PubMed  CAS  Google Scholar 

  • Damasio AR, van Hoesen GW (1985) The limbic system and the localisation of herpes simplex encephalitis. J Neurol Neurosurg Psychiatry 48: 297–301

    Article  PubMed  CAS  Google Scholar 

  • Davis LE, Johnson RT (1979) An explanation for the localisation of herpes simplex encephalitis. Ann Neurol 5: 2–5

    Article  PubMed  CAS  Google Scholar 

  • Dawson CR (1984) Ocular herpes simplex virus infections. Clin Dermatol 2: 56–66

    Article  PubMed  CAS  Google Scholar 

  • Dawson C, Togni B, Moore TE (1968) Structural changes in chronic herpetic keratitis: studied by light and electron microscopy. Arch Ophthalmo 179: 740–747

    Google Scholar 

  • De Venecia G, Zu Rhein GM, Pratt MU, Kisken W (1971) Cytomegalic inclusion retinitis in an adult. A clinical histopathologic and ultrastructural study. Arch Ophthalmo 186: 44–57

    Google Scholar 

  • Denny-Brown D, Adams RD, Fitzgerald PJ (1944) Pathologic features of herpes zoster: a note on “geniculate herpes”. Arch Neuro 151: 216–231

    Google Scholar 

  • Douglas RG, Anderson MS, Weg JG, et al. (1969) Herpes simplex virus pneumonia. JAMA 210: 902–904

    Article  PubMed  Google Scholar 

  • Drachman DA, Adams RD (1962) Herpes simplex and acute inclusion-body encephalitis. Arch Neurol 7: 45–53

    PubMed  CAS  Google Scholar 

  • Esiri MM (1982) Herpes simplex encephalitis, an immunohistological study of the distribution of viral antigen within the brain. J Neurol Sci 54: 209–226

    Article  PubMed  CAS  Google Scholar 

  • Goldman JN, Dohlman CH, Krovitt BA (1969) The basement membrane in recurrent epithelial erosion syndrome. Trans Am Acad Ophthalmol Otolaryngol: 73: 471–81

    PubMed  CAS  Google Scholar 

  • Goodell SE, Quinn TC, Mkrtichian E, Schuffler MD, Holmes KK, Corey L (1983) Herpes simplex virus proctitis and homosexual men: clinical, sigmoidoscopic and histopathological features. N Engl J Med 308: 868–871

    Article  PubMed  CAS  Google Scholar 

  • Graham BS, Snell JD (1983) Herpes simplex virus infection of the adult lower respiratory tract. Medicine, Baltimore: 62: 384–393

    Google Scholar 

  • Haber H, Milne JA, Symmers WSC (1980) The skin. In: Symmers WSC (ed) Systemic pathology, vol 6, 2nd edn. Churchill Livingstone, Edinburgh, pp 2626–2822

    Google Scholar 

  • Hagler WS, Walters DV, Nahmias AJ (1969) Ocular involvement in neonatal herpes simplex virus infection. Arch Opthalmol: 82: 169–176

    CAS  Google Scholar 

  • Harstock RJ (1968) Postvaccinal lymphadenitis. Hyperplasia of lymphoid tissue that simulates malignant lymphomas. Cancer 21: 632–649

    Article  Google Scholar 

  • Hass GM (1935) Hepato-adrenal necrosis with intranuclear inclusion bodies: report of a case. Am J Pathol 11: 127–142

    PubMed  CAS  Google Scholar 

  • Hull HF, Blumhager JD, Benjamin D, Corey L (1984) Herpes simplex viral pneumonitis in childhood. J Pediatr 104: 211–215

    Article  PubMed  CAS  Google Scholar 

  • Jellinek EH, Tulloch WS (1976) Herpes zoster with dysfunction of bladder and anus. Lancet ii: 1219–1222

    Article  Google Scholar 

  • Johnson RT, Mims CA (1968) Pathogenesis of viral infections of the nervous system. N Engl J Med 278: 23–38, 84–92

    Article  PubMed  CAS  Google Scholar 

  • Josey WE, Nahmias AJ, Naib ZM, Utley PM, McKenzie WJ, Coleman MT (1966) Genital herpes simplex infection in the female. Am J Obstet Gynecol: 96, 493–501

    PubMed  CAS  Google Scholar 

  • Lapsley M, Kettle P, Sloan JM (1984) Herpes simplex lymphadenitis: a case report and review of the published work. J Clin Pathol 37: 1119–1122

    Article  PubMed  CAS  Google Scholar 

  • Lightdale CJ, Wolf DJ, Marcucci RA, et al. (1977) Herpetic esophagitis in patients with cancer: antemortem diagnosis by brush cytology. Cancer 39: 223–226

    Article  PubMed  CAS  Google Scholar 

  • McDougal RA, Beamer PR, Hellerstein S (1954) Fatal herpes simplex hepatitis in a newborn infant. Am J Clin Pathol 24: 1250–1258

    PubMed  CAS  Google Scholar 

  • McKendall RR (1980) Comparative neurovirulence and latency of HSV 1 and HSV 2 following foot pad inoculation in mice. J Med Virol 5: 25–32

    Article  PubMed  CAS  Google Scholar 

  • McKenzie D, Hansen JDL, Becker W (1959) Herpes simplex virus infection: dissemination in association with malnutrition. Arch Dis Child 34: 250–256

    Article  PubMed  CAS  Google Scholar 

  • McMenemey WH, Thomas Smith W (1979) The central nervous system. In: Symmers WSC (ed) Systemic pathology, vol 5,2nd edn. Churchill Livingstone, Edinburgh, pp 2041–2159

    Google Scholar 

  • Mertz GJ, Schmidt O, Jourden JL et al. (1985) Frequency of acquisition of first episode genital infection with herpes simplex virus from symptomatic and asymptomatic source contacts. Sex Transm Dis 12: 33–39

    Article  PubMed  CAS  Google Scholar 

  • Meyers R, Chitjian P (1976) Immunology of herpes virus infection: immunity to herpes simplex virus in eye infections. Surv Ophthalmol 21: 194–204

    Article  PubMed  CAS  Google Scholar 

  • Meyers-Elliot R, Pettit R, Maxwell W (1980) Viral antigens in the immune rings of herpes simplex stromal keratitis. Arch Ophthalmol 98: 897–904

    Google Scholar 

  • Mintz H, Drew WL, Hoo R, Finley TN (1980) Age dependent resistance of human alveolar macrophages to herpes simplex virus. Infect Immun 28: 417–420

    PubMed  CAS  Google Scholar 

  • Nahmias AJ, Hagler WS (1972) Ocular manifestations of herpes simplex in the newborn (neonatal ocular herpes). Int Ophthalmol Clin 12: 191–213

    PubMed  CAS  Google Scholar 

  • Nahmias AJ, Alford CA, Korones SB (1970) Infection of the newborn with herpes virus hominis. Adv Paediatr 17: 185–226

    CAS  Google Scholar 

  • Nahmias AJ, Keyserling HH, Kerrick G (1983) Herpes simplex. In: Remington J S, Klein J O (eds) Infectious diseases of the fetus and newborn infant. Saunders WB, Philadelphia, pp 156–190

    Google Scholar 

  • Naib ZM (1966) Exfoliative cytology of viral cervico-vaginitis. Acta Cytol (Baltimore) 10: 126–129

    Google Scholar 

  • Naib ZM (1984) Cytologic diagnosis of herpes simplex virus infection. Clin Dermatol 2: 83–89

    Article  PubMed  CAS  Google Scholar 

  • Nash G, Foley FD (1970) Herpetic infection of the middle and lower respiratory tract. Am J Clin Pathol 54: 857–863

    PubMed  CAS  Google Scholar 

  • Nash G, Ross JS (1974) Herpetic esophagitis, a common cause of esophageal ulceration. Hum Pathol 5: 339–345

    Article  PubMed  CAS  Google Scholar 

  • O’Connor GR (1976) Recurrent herpes simplex uveitis in humans. Surv Ophthalmol: 21, 165–170

    Article  PubMed  Google Scholar 

  • Overall JC, Kern ER, Schlitzer RL, Friedman SB, Glasgow LA (1975) Central herpesvirus hominis infection in mice. I. Development of an experimental model. Infect Immun 11: 476–480

    Google Scholar 

  • Raga J, Chrystal V, Coovadia HM (1984) Usefulness of clinical features and liver biopsy in diagnosis of disseminated herpes simplex infection. Arch Dis Child 59: 820–824

    Article  PubMed  CAS  Google Scholar 

  • Rouse BT (1985) Immunopathology of herpesvirus infection. In: Roizman B, Lopez C (eds) The herpesviruses: immunobiology and prophylaxis of human herpesvirus infection, vol 4. Plenum Press, New York, pp 103–119

    Google Scholar 

  • Salvador AN, Harrison EG, Kyle RA (1971) Lymphadenopathy due to infectious mononucleosis. Its confusion with malignant lymphoma. Cancer 27: 1029–1040

    Google Scholar 

  • Schwartz JN, Cashwell F, Hawkins HK, Klintworth GK (1976) Necrotizing retinopathy with herpes zoster opthalmicus: a light and electron microscopical study. Arch Pathol Lab Med 100: 386–391

    PubMed  CAS  Google Scholar 

  • Singer DB (1981) Pathology of neonatal herpes simplex virus infections. In: Rosenberg HS, Berstein J (eds) Perspectives in pediatric pathology, vol 6, Masson, New York, pp 243–278

    Google Scholar 

  • Taylor RJ, Saul SH, Dowling JN, Hakala TR, Peel RL, Ho M (1981) Primary disseminated herpes simplex infection with fulminant hepatitis following renal transplantation. Arch Intern Med 141: 1519–1521

    Article  PubMed  CAS  Google Scholar 

  • Trofatter KF Jr, Daniels CA, Williams RJ Jr, Gall SA (1979) Growth of type 2 herpes simplex virus in newborn and adult mononuclear leukocytes. Intervirology 11: 117–123

    Article  PubMed  Google Scholar 

  • Walker DP, Longson M, Lawler W, Mallick NP, Davies JS, Johnson RWG (1981) Disseminated herpes simplex virus infection with hepatitis in an adult renal transplant recipient. J Clin Pathol 34: 1044–1046

    Article  PubMed  CAS  Google Scholar 

  • Witzelben CL, Driscoll SG (1965) Possible transplacental transmission of herpes simplex infection. Pediatrics 36: 192–199

    Google Scholar 

  • Wolter JR, Shapiro I, Whitehouse F (1956) Pathology of experimental primary herpetic keratitis in rabbits. J Ophthalmol 41: 639–645

    CAS  Google Scholar 

  • Wright HT Jr, Miller A (1965) Fatal infection in a newborn infant due to herpes simplex viruses. Report of a case diagnosed before death. J Pediatr 67: 130–132

    Google Scholar 

  • Zuelzer WW, Stulberg CS (1952) Herpes simplex virus as the cause of fulminating visceral disease and hepatitis in infancy. Report of eight cases and isolation of the virus in one case. Am J Dis Child 83: 421–439

    CAS  Google Scholar 

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Authors and Affiliations

  1. Academic Department of Genito-Urinary Medicine, James Pringle House, The Middlesex Hospital, University College and Middlesex School of Medicine, London, W1N 8AA, UK

    Adrian Mindel MB, BCh, MSc, MRCP (Senior Lecturer and Honorary Consultant in Genito-Urinary Medicine)

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  1. Adrian Mindel MB, BCh, MSc, MRCP
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© 1989 Springer-Verlag Berlin Heidelberg

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Mindel, A. (1989). Pathology and Pathogenesis. In: Herpes Simplex Virus. The Bloomsbury Series in Clinical Science. Springer, London. https://doi.org/10.1007/978-1-4471-1683-7_6

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  • DOI: https://doi.org/10.1007/978-1-4471-1683-7_6

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1685-1

  • Online ISBN: 978-1-4471-1683-7

  • eBook Packages: Springer Book Archive

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