Abstract
There are two herpes simplex viruses (HSV) designated HSV 1 and HSV 2. Although the two viruses are morphologically identical and have approximately 50% DNA similarity, there are a number of biological, biochemical, genomic and clinical differences between them. These are summarised in Table 1.1. The clinical differences will be highlighted in subsequent chapters, but here I will cover the basic virology and immunology of HSV infection.
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References
Ashley R, Benedetti J, and Corey L (1985) Humoral immune response to HSV 1 and HSV 2 viral proteins in patients with primary genital herpes. J Med Virol 17: 153–166
Balachandran N, Bacchetti S, Rawls WE (1982) Protection against lethal challenge of BALB/c mice by passive transfer of monoclonal antibodies to five glycoproteins of herpes simplex virus type 2. Infect Immun 37: 1132–1137
Bauke RB, Spear PG (1979) Membrane proteins specified by herpes simplex viruses. V. Identification of an Fc-binding glycoprotein. J Virol 46: 103–112
Carter VC, Rice PL, Tevethia SS (1982) Intratypic and intertypic specificity of lymphocytes involved in recognition of herpes simplex virus glycoproteins. Infect Immun 37: 116–126
Chan WL (1983) Protective immunization of mice with specific HSV 1 glycoproteins. Immunology 49: 343–352
Clumek N, Sonnet J, Taelman H (1984) Acquired immunodeficiency syndrome in African patients. N Engl J Med 310: 492–497
Corey L, Spear PG (1986) Infection with herpes simplex viruses, (first of two parts.) N Engl J Med 314: 686–691
Corey L, Reeves WC, Holmes KK (1979) Cellular immune response in genital herpes simplex virus infection. N Engl J Med 299: 986–991
Corey L, Adams HG, Brown ZA, Holmes KK (1983) Genital herpes simplex virus infections. Clinical manifestations, course and complications. Ann Intern Med 98: 958–972
Dales S (1973) Early events in cell-animal virus interactions. Bacteriol Rev 37: 103–135
DeLuca N, Bzik D, Person S, Snipes W (1981) Early events in herpes simplex virus type 1 infection; photosensitivity of fluorescein isothiocyanate-treated virions. Proc Natl Acad Sci USA 78: 912–916
Dix RD, Mills J (1985) Acute and latent herpes simplex viruses. Neurological diseases in mice immunized with purified glycoproteins gB or gD. J Med Virol 17: 9–18
Eberle R, Mou SW (1983) Relative titres of antibodies to individual polypeptide antigens of herpes simplex virus type 1 human sera. J Infect Dis 148: 443–444
Eberle R, Russell RG, Rouse BT (1981) Cell mediated immunity to herpes simplex virus: recognition of type-specific and type-common surface antigens by cytotoxic T cell populations. Infect Immun 34: 795–803
Fenwick M, Roizman B (1977) Regulation of herpesvirus macromolecular synthesis. VI Synthesis and modification of viral polypeptides in enucleated cells. J Virol 22: 720–725
Frenkel N, Roizman B (1971) Herpes simplex virus: genome size and redundancy studied by renaturation kinetics. J Virol 8: 591–593
Friedman HM, Cohen GH, Eisenberg RJ, Seidel CA, Cines DB (1984) Glycoproteins C of herpes simplex virus 1 as a receptor for the C3b complement component on infected cells. Nature 309: 633–635
Graham BS, Snell JD (1983) Herpes simplex virus infection of the adult lower respiratory tract. Medicine (Baltimore) 62: 384–393
Greene MI, Weiner HL (1980) Delayed hypersensitivity in mice infected with reovirus. II. Induction of tolerance and suppressor T cells to viral specific gene products. J Immunol 125: 283–287
Grewal AS, Rouse BT, Babiuk LA (1977) Mechanisms of resistance to herpesvirus: comparison of the effectiveness of different cell types in mediating antibody-dependent cell-mediated cytoxicity. Infect Immun 15: 698–703
Gridlund M, Orn A, Wigzell H, Senik A, Gresser I (1978) Enhanced NK cell activity in mice infected with interferon and interferon inducers. Nature 273: 759–761
Hayashida I, Nagafuchi S, Hayashi Y et al (1982) Mechanism of antibody-mediated protection against herpes simplex virus infection in athymic mice: requirement of Fc portion of antibody. Microbiol Immunol 26: 497–509
Herberman RB, Ortaldo JR (1981) Natural killer cells. Their role in defenses against disease. Science 214: 24–30
Honess RW, Roizman B (1974) Regulation of herpesvirus macromolecular synthesis in cascade regulation of the synthesis of 3 groups of viral proteins. J Virol 14: 8–19
Jayasuriya AK, Nash AA (1985) Pathogenesis and immunobiology of herpes simplex virus in mouse and man. Cancer Invest 3: 199–207
Johnson DC, Spear PG (1982) Monensin inhibits the processing of herpes simplex virus glyco-proteins, their transport to the cell surface and the egress of virions from infected cells. J Virol 43: 1102–1112
Kahlon J, Lakeman FD, Ackermann M, Whitley RJ (1986) Human antibody response to herpes simplex virus specific polypeptides after primary and recurrent infection. J Clin Microbiol 23: 725–730
Kapoor AK, Nash AA, Wildy P (1982) Pathogenesis of herpes simplex virus in B cell-suppressed mice: the relative roles of cell mediated and humoral immunity. J Gen Virol 61: 127–131
Kozak M, Roizman B (1974) Regulation of herpesvirus macromolecular synthesis: nuclear retention of non-translated viral RNA sequences. Proc Natl Acad Sci USA 71: 4322–4326
Larson HS, Russel RG, Rouse BT (1983) Recovery from lethal herpes simplex virus type 1 infection is mediated by cytotoxic T lymphocyte. Infect Immun 41: 197–204
Lee FK, Coleman RM, Pereira L, Bailey PD, Tatsuno M, Nahmias AJ (1985) Detection of herpes simplex virus type 2 specific antibody with glycoprotein G. J Clin Microbiol 22: 641–644
Lee FK, Pereira L, Griffin C, Reid E, Nahmias A (1986) A novel glycoprotein for detection of herpes simplex virus type 1 specific antibodies. Virol Methods 14: 111–118
Little SP, Jofre JT, Courtney RJ, Schaffer PA (1981) A virion-associated glycoprotein essential for infectivity of herpes simplex virus type 1. Virology 115:149–160 Lopez C (1975)
Genetics of natural resistance to herpes virus infections in mice. Nature 258:152–153
Lopez C (1980) Genetic resistance to herpes infection. Role of natural killer cells. In: Skamene E, Kongshaun P, Landy M (eds) Genetic control of natural resistance to infection and malignancy. Acadamic Press, New York, pp 253–265
Mann D, Hilty M (1982) Antibody response to herpes simplex virus type 1 polypeptides and glycoproteins in primary and recurrent infection. Pediatr Res 16: 176–186
Meignier B, Jourdier TM, Norrild B, Pereira L, Roizman B (1987) Immunization of experimental animals with reconstituted glycoprotein mixtures of herpes simplex virus 1 and 2. Protection against challenge with virulent virus. J Infect Dis 155: 921–930
Merigan TC, Stevens DA (1971) Viral infection in man associated with acquired immunological deficiency states. Fed Proc 30: 1858–1864
Midlvan D, Mathur U, Enslow RW, et al (1982) Opportunistic infections and immune deficiency in homosexual men. Ann Intern Med 69: 700–704
Mogensen SC, Andersen HK (1978) Role of activated macrophages in resistance of congenitally athymic nude mice to hepatitis induced by herpes simplex type 2. Infect Immun 19: 792–798
Morgan C, Rose HM, Mednis B (1968) Electron microscopy of herpes simplex virus. I. Entry. J Virol 2: 507–516
Mori R, Tasaki T, Kimura G, Takeya K (1967) Depression of acquired resistance against herpes simplex virus infection in neonatally thymectomized mice. Arch Ges Virusforsch 21: 459–462
Muller SA, Herrman EC, Winkelmann RK (1972) Herpes simplex infections in hematologic malignancies. Am J Med 52: 102–114
Nagafuchi S, Oda H, Mori R, Taniguchi T (1979) Mechanism of acquired resistance to herpes simplex virus infection as studied in nude mice. J Gen Virol 44: 715–723
Nahmias AJ, Roizman B (1973) Infection with herpes simplex viruses 1 and 2. (First of three parts.) N Engl J Med 667–674
Nahmias AJ, Keyserling HH, Kerrick G (1983) Herpes simplex. In: Remington JS, Klein JO (eds) Infectious diseases of the fetus and newborn infant. WB Saunders, Philadelphia, PA, pp 156–190
Nash AA, Field HJ, Quartey-Papafio R (1980a) Cell mediated immunity to herpes simplex virus-infected mice: induction, characterisation and antiviral effects of delayed-type hypersensitivity. J Gen Virol 48: 351–357
Nash AA, Quartey-Papafio R, Wildy P (1980b) Cell-mediated immunity in herpes simplex virus-infected mice: functional analysis of lymph nodes cells during periods of acute and latent infection, with reference to cytotoxic and memory cells. J Gen Virol 49: 309–317
Nash AA, Gell PGH, Wildy P (1981a) Tolerance and immunity in mice infected with herpes simplex virus: simultaneous induction of protective immunity and tolerance to delayed-type hypersensitivity. Immunology 43: 153–159
Nash AA, Phelan J, Wildy P (1981b) Cell-mediated immunity in herpes simplex virus infected mice: H2-mapping of the delayed-type hypersensitivity response and the antiviral T cell response. J Immunol 126: 1260–1262
Nash AA, Phelan J,. Gell PGH, Wildy P (1981c) Tolerance and immunity in mice infected with herpes simplex virus: studies on the mechanism of tolerance to delayed-type hypersensitivity. Immunology 43: 363–364
Norrild B, Shore SL, Cromeans TL, Nahmias AJ (1980) Participation of three major glycoprotein antigens of herpes simplex virus type 1 early in the infectious cycle as determined by antibody dependent cell-mediated cytotoxicity. Infect Immun 28: 38–44
Oakes JE (1975) Role for cell mediated immunity in the resistance of mice to subcutaneous herpes simplex infection. Infect Immunol 12: 166–172
Pereira L, Klassen T, Baringer J (1980) Type common and type specific monoclonal antibodies to herpes simplex virus type 1. Infect Immun 29: 724–732
Rager-Zisman B, Bloom BR (1974) Immunological destruction of herpes simplex virus 1 infected cells. Nature 251: 542–543
Rager-Zisman B, Allison AC (1976) Mechanisms of immunologic resistance to herpes simplex virus (HSV 1) infection. J Immunol 116: 35–40
Roizman B (1979) The organisation of the herpes simplex virus genomes. Annu Rev Genet 13: 25–57
Roizman B, Furlong D (1974) The replication of herpesviruses. In: Fraekel-Conrat H, Wagner RR (eds) Comprehensive virology, Plenum Press, New York pp 229–403
Russell AS, Schlaut J (1977) Association of HLA-A1 antigen and susceptibility to recurrent cold sores. Arch Dermatol 113: 1721–1722
Sarmiento M, Haffey M, Spear PG (1979) Membrane proteins specified by herpes simplex viruses. III. Role of glycoproteins VP7 ( B2) in virion infectivity. J Virol 29: 1149–1158
Schrier RD, Pizer LI, Moorhead JW (1983) Tolerance and suppression of immunity to herpes simplex virus; different presentation of antigen induced different types of suppressor cells. Infect Immun 40: 514–522
Sethi KK, Omata Y, Schneweis KE (1983) Protection of mice from fatal herpes simplex virus type 1 infection by adoptive transfer of cloned virus-specified and H 2 restricted cytotoxic T lymphocytes. J Gen Virol 64: 443–447
Shore SL, Cromeans TL, Romano TJ (1976) Immune destruction of virus infected cells early in the infectious cycle. Nature 262: 695–696
Siegal FP, Lopez C, Hammer GS, et al. (1981) Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. N Engl J Med 305: 1439–1444
Simmons A, Nash AA (1984) Zosteriform species of herpes simplex virus as a model of recrudescence and its use to investigate the roll of immune cells in prevention of recurrent disease. J Virol 52: 816–821
Sinipions A, Nash AA (1987) Effect of B cell suppression on primary infection and reinfection of mice with herpes simplex virus. J Infect Dis 155: 649–654
Spear PG (1984) Glycoproteins specified by herpes simplex virus. In: Roizmann B. (ed) The herpesviruses, vol 3, Plenum Press, New York, pp 315–356
Tsutsumi H, Bernstein JM, Riepenhoff-Talty M, Cohen E, Orsini F, Ogra PL (1986) Immune responses to herpes simplex virus in patients with recurrent herpes labialis. I. Development of cell mediated cytotoxic responses. Clin Exp Immunol 66: 507–515
Vahlne A, Svennerholm B, Lycke E (1979) Evidence for herpes simplex virus type-selective receptors on cellular plasma membranes. J Gen Virol 44: 217–225
Vahlne A, Svennerholm B, Sandberg M, Hamberger A, Lycke E (1980) Differences in attachment between herpes simplex virus type 1 and type 2 viruses to neurones and glial cells. Infect Immun 28: 675–680
Vilcek J, Sreevalsan T (1984) Fundamentals of virus structure and replication. In: Galasso G J, Merrigan TC, Buchanan RA (eds) Antiviral agents and viral diseases of man, 2nd edn, Raven Press, New York, pp 1–33
Weigent DA, Langford MP, Fleischmann WR Jr, Stanton GJ (1983) Potentiation of lymphocyte natural killing by mixture of alpha or beta interferon with recombinant gamma interferon. Infect Immun 40: 35–38
Welsh RM (1981) Natural cell-mediated immunity during viral infection. Curr Top Microbiol Immunol 92: 83–106
Whitley RJ, Nahmias AJ, Visintine AM, Fleming CL, Alford CA (1980) The natural history of herpes simplex virus of mother and newborn. Pediatrics 66: 489–494
Wildy P, Russell WC, Home RW (1960) The morphology of herpes virus. Virology 12: 1044–1052
Zawatsky R, Hilfenhaus J, Marcucci F, Kirchner H (1981) Experimental infection of inbred mice with herpes simplex type 1. I. Investigation of humoral and cellular immunity of interferon induction. J Gen Virol 53: 31–38
Zweerink H, Corey L (1982) Virus-specific antibodies in sera from patients with genital herpes simplex virus infection. Infect Immun 37: 413–421
Zweerink H, Stanton L (1981) Immune response to herpes simplex virus infections: virus specific antibodies in sera from patients with recurrent facial infections. Infect Immun 31: 624–630
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Mindel, A. (1989). Virology and Immunology. In: Herpes Simplex Virus. The Bloomsbury Series in Clinical Science. Springer, London. https://doi.org/10.1007/978-1-4471-1683-7_1
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