Abstract
The idea that a radioactive isotope could be used to image or treat pathology arose in the 1940s when radioiodine and radioactive phosphorus became available to clinicians for the first time. The concept of a “magic bullet” was coined by Henry Wagner (Wagner 1975). It was envisaged that a series of radioactive magic bullets would be developed which could be used to diagnose and treat a whole series of diseases. The success of radioiodine therapy is well known but it is only after nearly 50 years that there are signs that this dream might become a reality.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Beierwaltes WH, Lieberman LM, Ansari AN (1971) Visualisation of the human adrenal glands by in vivo scintillation scanning. JAMA 216:275–277
Cheung N-KV, Neely JE, Landmeiar B, Nelson D, Miraldi F (1987) Targetting of ganglioside GD2 monoclonal antibody to neuroblastoma. J Nucl Med 28:1577–1583
Endo K, Shiomi K, Kasagi K et al. (1984) Imaging of medullary thyroid cancer with 131I-mIBG. Lancet ii:233
Feine U, Muller-Schauenberg W, Treuner J et al. (1987) Metaiodobenzylguanidine (mIBG) labelled with 123I/131I in neuroblastoma diagnosis and follow-up treatment with a review of diagnostic results of the International Workshop in Paediatric Oncology held in Rome, September 1986. Med Paediatr Oncol 15:181–187
Hoefnagel CA (1987) The role of 131I-mIBG in the diagnosis and therapy of carcinoid. Eur J Nucl Med 13:187–191
Horne T, Granowski M, Dicks-Mireaux C et al. (1985) Neuroblastoma imaged with 123I-meta-iodo-benzylguanidine and with l23I-labelled monoclonal antibody UJ 13A against neural tissue. Br J Radiol 58:476–480
Larson SM (1985) Radiolabelled monoclonal anti-tumour antibodies in diagnosis and therapy. J Nucl Med 26:538–545
Morales JO, Beierwaltes WH, Counsell RE et al. (1976) The concentration of radioactivity from labelled epinephrine and its precursors in the dog adrenal medulla. J Nucl Med 8:800–809
Perdrisot R, Rohmer V, Lejeune JJ et al. (1988) Thyroid uptake of mIBG in Sipple’s syndroma. Eur J Nucl Med 14:37–38
Shapiro B, Copp JE, Sisson JC et al. (1985) Iodine-131 metaiodobenzylguanidine for the locating of suspected phaeo-chromocytoma: experience in 400 cases. J Nucl Med 26:576–585
Shapiro B, Von Moll L, McEwan A et al. (1986) I-131-metaiodobenzylguanidine (MIBG) uptake by a wide range of neuroendocrine tumors other than phaeochromocytoma and neuroblastoma. J Nucl Med 27:908 (abstr)
Smit AJ, Van Essen LH, Hollenia H et al. (1984) 131I-mIBG uptake in a non-secreting paraganglioma. J Nucl Med 25:984–986
Valk TW, Frager MS, Gross MD et al. (1981) Spectrum of phaeochromocytoma in multiple endocrine neoplasia: a scintigraphic portrayal using 131I-metaiodobenzylguanidine. Ann Int Med 94:762–767
Vaughan ATM, Anderson P, Dykes PW et al. (1987) Limitations to the killing of tumours using radiolabelled antibodies. Br J Radiol 60:567–578
Wagner HJ (1975) Introduction. In: Wagner HJ (ed) Nuclear medicine. HP Publishing, New York, p XIII
Wieland DD, Swanson DP, Brown LE et al. (1979) Imaging the adrenal medulla with an I-131 labeled anti-adrenergic agent. J Nucl Med 20:155–158
Wieland DM, Wu J, Brown LE et al. (1980) Radiolabeled adrenergic neuron-blocking agents: adrenomedullary imaging with [131I]iodobenzylguanidine. J Nucl Med 21:349–353
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Moyes, J.S.E., McCready, V.R., Fullbrook, A.C. (1989). Introduction. In: Neuroblastoma. Springer, London. https://doi.org/10.1007/978-1-4471-1674-5_1
Download citation
DOI: https://doi.org/10.1007/978-1-4471-1674-5_1
Publisher Name: Springer, London
Print ISBN: 978-1-4471-1676-9
Online ISBN: 978-1-4471-1674-5
eBook Packages: Springer Book Archive