A Computer-Controlled Hyperthermia System

  • S. W. Hughes
  • J. E. Saunders
  • A. R. Timothy


Hyperthermia, raised temperature, has been used as a means of treating cancer for centuries. Hippocrates (400 bc) and Galen (200 bc) used red-hot irons to treat small tumours. Much later, after the Renaissance, there are many reports of spontaneous tumour regression in patients with fevers produced by erysipelas, malaria, smallpox, tuberculosis and influenza. These illnesses produce fevers of about 40°C which last for several days. Temperatures of at least 40°C were found to be necessary for tumour regression. Towards the end of the nineteenth century pyrogenic bacteria were injected into patients with cancer. In 1896, Coley used a mixture of erysipelas and B. prodigeosus toxins, with some success.


Target Temperature Thermocouple Junction Thermal Dose Steady Phase Forward Power 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Arcangeli G. (1983) Tumour control and therapeutic gain with different schedules of combined radiotherapy and local hyperthermia in human cancer. Int J Radiat Oncol Biol Phys 9: 1125–34PubMedCrossRefGoogle Scholar
  2. Coley WB, (1896) The therapeutic value of the mixed toxins of erysipelas and Bacillus prodigeosus in the treatment of inoperable malignant tumours. Am J Med Sci 112: 251–281CrossRefGoogle Scholar
  3. Conner WG (1977) Prospects for hyperthermia in human cancer therapy. II. Implications of biological and physical data for applications of hyperthermia in man. Radiology 123: 497–503Google Scholar
  4. Dewey WC (1976) Cellular responses to combinations of hyperthermia and radiation. Radiology 123: 463–74Google Scholar
  5. Field SB (1987) Studies relevant to a means of quantifying the effects of hyperthermia. Int J Hyperthermia 4: 291–296CrossRefGoogle Scholar
  6. Hand JW, James JR (1986) Physical techniques in clinical hyperthermia. Research Studies Press, Letchworth, England.Google Scholar
  7. Sapareto SA, Dewey WC (1984) Thermal dose determination in cancer therapy. Int J Radiat Oncol Biol Phys 10: 787–800PubMedCrossRefGoogle Scholar
  8. Westermark N (1927) The effect of heat upon rat tumours. Skand Arch Physiol 52: 257–322Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • S. W. Hughes
  • J. E. Saunders
  • A. R. Timothy

There are no affiliations available

Personalised recommendations