Immunogenetic factors influencing the survival of the fetal allograft

  • T. J. GillIII
  • H. N. Ho
  • A. Kanbour
  • T. A. Macpherson
  • D. N. Misra
  • H. W. Kunz


The ability of the fetal allograft to avoid immune rejection presents a perplexing problem in transplantation immunology. Medawar(l) and Billingham(2) discussed a variety of potential mechanisms by which the fetal allograft might be protected, and much work has been done to examine the various possibilities. (3–8) A considerable amount of attention has been devoted to the question of whether there are Class I antigens in the placenta and, if so, where they are and what type of antigenic determinants they carry. Such antigens have been demonstrated in the placenta of the mouse,(9,10) the human(11–14) and the rat(15–17) Immunochemical studies of these placental Class I antigens showed that they carry broadly crossreactive, public antigenic determinants in both the rat(15) and the human. (18,19) There are no Class II antigens in the placenta of the mouse,(20,21) the human(11,14,15,22) and the rat. (23)


Trophoblast Cell Classical Class Transplantation Antigen Immunogold Technique Glycogen Cell 
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Copyright information

© The Royal College of Obstetricians and Gynaecologists 1988

Authors and Affiliations

  • T. J. GillIII
  • H. N. Ho
  • A. Kanbour
  • T. A. Macpherson
  • D. N. Misra
  • H. W. Kunz

There are no affiliations available

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