Antigen expression by cells of the conceptus before, during and after implantation
Knowledge of the antigenic status of the cells of the conceptus is being sought largely by workers in the fields of developmental biology and reproductive immunology. The former are seeking to determine whether cell surface molecules are useful markers of differentiation and involved in cellular recognition and interaction whilst the latter are attempting to elucidate their role in signalling the presence of a viable embryo and establishing a feto-maternal immunological dialogue that may be necessary for the maintenance of pregnancy. As long ago as 1951. Brambell and his colleagues(1) asserted that immune responses must play a part in the production and survival of the young in man and other mammals. More than thirty years later. the precise nature and extent of these responses are still far from clear. with the notable exception of the transfer of maternal immunoglobulins for the protection of the neonate against environmental pathogens.
KeywordsMajor Histocompatibility Complex Trophoblast Cell Trophoblastic Giant Cell Reprod Immunol Maternal Immune Response
Unable to display preview. Download preview PDF.
- 1.Brambell FWR, Hemmings WA, Henderson M. Antibodies and Embryos. London: The Athlone Press, University of London, 1951.Google Scholar
- 2.Medawar PB. Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp Soc Exp Biol 1953; 7: 320–338.Google Scholar
- 11.Jenkinson EJ. The in vitro blastocyst outgrowth system as a model for the analysis of peri-implantation development. In: Development in Mammals Vol. 2. Ed: MH Johnson. Amsterdam: North-Holland Publishing Co., 1977; pp.151–172.Google Scholar
- 20.Singh B, Raghupathy R, Anderson DJ, Wegmann TG. The placenta as an immunobiological barrier between mother and fetus. In: Immunology of Reproduction. Eds. TG Wegmann and TJ Gill. Oxford: Oxford University Press, 1983. pp.229–230.Google Scholar
- 31.Clark DA, Damji N, Chaput A, Daya S, Rosenthal KL, Brierley J. Deciduaassociated suppressor cells and suppressor factors regulating interleukin-2: their role in survival of the fetal allograft. In: Progress in Immunology, Vol. VI. Eds. B. Cinauer, RG Miller. New York: Academic Press, 1986. pp.1089–1099.Google Scholar
- 37.Pross H, Mitchell H, Werkmeister J. The sensitivity of placental trophoblast cells to intraplacental and allogeneic cytotoxic lymphocytes. Amer J Reprod Immunol Microbiol 1985; 8: 1–9.Google Scholar