Skip to main content

Effects of feto-maternal major histocompatibility differences on litter size in pigs

  • Chapter
Early Pregnancy Loss

Abstract

In mammalian reproduction the role of immunogenetic incompatibility between parents has been widely discussed.(1) The Major Histocompatibility Complex (MHC) of mammalian species is known to playa crucial role, both in selfrecognition and in the recognition and response to antigens presented by an allograft. As the fetus can be considered a semi-allograft, the MHC has been a prime candidate for investigation as an influencing factor in reproduction.(2.3)

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Gill TJ. Immunological and genetic factors influencing pregnancy and development. Am J Reprod Immunol Microbiol 1986; 10: 116–120.

    PubMed  Google Scholar 

  2. Beer AE, Billingham RE. Histocompatibility gene polymorphisms and maternal-fetal interactions. Trans Proc 1977; 9: 1393–1401.

    CAS  Google Scholar 

  3. Giphart MJ, O’Amaro J. HLA and reproduction? J Immunogenet 1983; 10: 25–29.

    Article  PubMed  CAS  Google Scholar 

  4. Coulam CB, Moore SB, O’Fallon WM. Association between major histocompatibility antigens and reproductive performance. Am J Reprod Immunol Microbiol 1987; 14: 54–58.

    PubMed  CAS  Google Scholar 

  5. Voisin IE, Monnot P, Voisin GA. Maternal alloimmune reactions towards the murine conceptus and graft-versus-host reaction (GVHR) I. Priming for anti-paternal GVHR by gestation. J Reprod Immunol 1986; 9: 73–83.

    Article  PubMed  CAS  Google Scholar 

  6. Günther E. Genetic control of ami-male immune responsiveness in rat. Trans Proc 1985; 17: 1840–1841.

    Google Scholar 

  7. Steven DH. Biology of trophoblast. In: Interspecies differencies in the structure and function of trophoblast. Eds. YW Loke, A Whyte. Amsterdam: Elsevier, 1983; pp.114–119.

    Google Scholar 

  8. Anderson LL. Early embryonic development in the pig. J Anim Sci 1974; 39: 986 (Abstract).

    Google Scholar 

  9. Dantzer V. Electron microscopy of the initial stages of placentation in the pig. Anat Embryol 1985; 172: 281–293.

    Google Scholar 

  10. Legault C, Leuillet M. Etude de quelques facteurs de variation du poids de l’embryon et du placenta chez la truie primipare au trentiene jour de la gestation. Ann Bio Anim Bioch Biophys 1973; 13: 25–36.

    Article  CAS  Google Scholar 

  11. Koch E. Establishment of pregnancy and its immunological implications in the pig. J Reprod Fertil 1985; Suppl. 33: 65–81.

    Google Scholar 

  12. Rudek Z, Kwiatkowska L. The possibility of detecting fetal lymphocytes in the maternal blood of the domestic pig, sus scrofula. Cytogenet Cell Genet 1983; 36: 580–583.

    Article  PubMed  CAS  Google Scholar 

  13. Meziou W, Chardon P, Flechon JE, Kalil J, Vaiman M. Expression of beta 2-microglobulin on preimplantation pig embryos. J Reprod Immunol 1983; 5: 73–80.

    Article  PubMed  CAS  Google Scholar 

  14. Hussein AM, Newby TJ, Bourne FJ. Immunohistochemical studies of the local immune system in the reproductive tract of the sow. J Reprod Immunol 1983; 5: 1–15.

    Article  PubMed  CAS  Google Scholar 

  15. Antczak DF, Miller JM, Remick LH. Lymphocyte alloantigens of the horse: II. Antibodies to ELA antigens produced during pregnancy. J Reprod Immunol 1984; 6: 283–297.

    Article  PubMed  CAS  Google Scholar 

  16. Linklater KA. Iso-antibodies to red cell antigens in pigs’ sera. l-Isoimmunisation of pregnancy in sows. Anim Blood Grps Biochem Genet 1971; 2: 201–214.

    Article  Google Scholar 

  17. Vesel sky L, Stanek R, Hradecky J. Effect of antibodies to boar spermatazoa on fertility in sows and rabbits. Arch Androl 1981; 7: 337–342.

    Article  PubMed  CAS  Google Scholar 

  18. Schmid DO, Cwik S, Krausslich H, Meyer J, Graf zu Dohna R. Uber Iymphocytotoxische antikorper bei weiblichen zuchtschweinen. Zbl Vet Med B 1978; 25: 517–523.

    CAS  Google Scholar 

  19. Linklater KA. Iso-antibodies to red cell antigens in pigs’ sera. 2. The incidence of isoantibodies to red cell antigens in the sera of adult pigs. Anim Blood Grps Biochem Genet 1971; 2: 215–220.

    Article  Google Scholar 

  20. Linklater KA, McTaggart, Imlah T. Haemolytic disease of the newborn, thrombocytopenic purpurea and neutropenia occurring concurrently in a litter of piglets. Br Vet J 1973; 129: 36–40.

    PubMed  CAS  Google Scholar 

  21. Jensen EL, Smith C, Baker IN, Cox DF. Quantitative studies on blood group and serum protein systems in pigs: II. effects on production and reproduction. J Anim Sci 1968; 27: 856–862.

    PubMed  CAS  Google Scholar 

  22. Rasmusen BA, Hagen KL. The H blood group system and reproduction in pigs. J Anim Sci 1973; 37: 568–573.

    PubMed  CAS  Google Scholar 

  23. Rasmusen BA. A and O blood types and reproduction in pigs. 67th annual meeting of the American Society of Animal Science. J Anim Sci 1975; 41: 256 (abstr).

    Google Scholar 

  24. Yau FD. Association of polymorphic blood group systems and relative fitness in pigs. Dissertation abstracts international, B (sciences and engineering) 1982; 43: 629.

    Google Scholar 

  25. Hruban V, Simon M, Hradecky J. Alloantigens common to erythrocytes and leucocytes in pigs. Anim Blood Grps Biochem Genet 1972; 3: 157–161.

    Article  Google Scholar 

  26. Rasmusen BA, Yau FD. Association of H blood types with heterosis for reproductive fitness in pigs. 18th International Conference on Animal Blood Groups and Biochemical Polymorphisms. Ottawa, Canada 1982; 112 (Abstract).

    Google Scholar 

  27. Marrable A W. The ischaemic extremities of the allantochorion of the pig and their relation to the endometrium. Res Vet Sci 1968; 9: 578–582.

    PubMed  CAS  Google Scholar 

  28. Flood PF. Endometrial differentiation in the pregnant sow and the necrotic tips of the allantochorion. J Reprod Fert 1973; 32: 539–543.

    Article  CAS  Google Scholar 

  29. Gerard H, Salmon H, Rombauts P. Les organes cibles potentiels de I’alloreactivité maternelle antifoetale, étude chez le porco In: Reproductive Immunology: maternofetalrelationships. Ed. G. Chaouat, Paris: Colloques INSERM, 1987; 154: pp.141–150.

    Google Scholar 

  30. Vaiman M, Renard C, Lafage P, Amateau J, Nizza P. Evidence for a histocompatibility system in swine (SLA). Transplantation 1970; 10: 155–164.

    Article  PubMed  CAS  Google Scholar 

  31. Renard C, Chardon P, Vaiman M. The pig histocompatibility system SLA: serological study on a group of antigenic specificities. Anim Blood Grps Biochem Genet 1982; 13: 161–177.

    Article  CAS  Google Scholar 

  32. Chardon P, Renard C, Vaiman M. Characterization of class II histocompatibility antigens in pigs. Anim Blood Grps Biochem Genet 1981; 12: 59–65.

    Article  CAS  Google Scholar 

  33. Vaiman M, Chardon P, Cohen D. DNA polymorphism in the major histocompatibility complex of man and various farm animals. Anim Genet 1986; 17: 113–133.

    Article  PubMed  CAS  Google Scholar 

  34. Geffrotin C, Popescu CP, Cribiu EP, Boscher J, Renard C, Chardon P, Vaiman M. Assignment of MHC in swine to chromosome 7 by in situ hybridization and serological typing. Anim Genet 1984; 27: 213–219.

    CAS  Google Scholar 

  35. Vaiman M, Chardon P, Renard C. Genetic organization of the pig SLA complex. Studies on nine recombinants and biochemical and lysostrip analysis. Immunogenetics 1979; 9: 353–361.

    Article  Google Scholar 

  36. Vaiman M, Hauptmann G, Mayer S. Influence of the major histocompatibility complex in the pig (SLA) on serum haemolytic complement levels. J Immunogenet 1978; 5: 59–65.

    Article  PubMed  CAS  Google Scholar 

  37. Geffrontin C, Grunwald D, Chardon P, Vaiman M. Swine MHC: mapping by chromosome flow sorting and spot hybridization. Anim Genet 1987; 18: 118 (Abstract).

    Google Scholar 

  38. Renard C, Luquet M, Gouillieux P, Vaiman M. Le polymorphisme du systeme majeur d’histocompatibilité SLA dans plusieurs races porcines en France. In: 18ème Journées de la recherche porcine en France. Paris: Institut Technique du Porc, 1986; pp.285–298.

    Google Scholar 

  39. . Renard C, Kristensen B, Gautschi C, Hruban V, Fredholm N, Vaiman M. Joint report on the first international comparison test on swine lymphocyte alloantigens (SLA). Anim Genet 1987; In press.

    Google Scholar 

  40. Kristensen B, Philipsen M, Lazary S, Renard C, de Weck AL. The swine histocompatibility system SLA: serological studies in the common Swiss and Danish swine breeds. Anim Blood Grps Bioch Genet 1985; 16: 109–124.

    Article  CAS  Google Scholar 

  41. Willis GL, Baglin MJ, Love RJ, Brown SC, Nicholas FW. A study of histoincompatibility and reproductive performance in pigs. Vet Rec 1985; p.601.

    Google Scholar 

  42. Bolet G. Timing and extent of embryonic mortality in pigs, sheep and goats: genetic variability. In: Embryonic mortality in farm animals. Program of coordination of research on livestock production and management. Ed. JM Sreenan, MG Diskin. Dordrecht: Martinus Nijhoff, 1986; pp.12–45.

    Chapter  Google Scholar 

  43. Vaimann M, Renard C. Deficit of piglets homozygous for the SLA histocompatibility complex in families. Anim Blood Grps Biochem Genet 1980; 11: 57 (Abstract).

    Google Scholar 

  44. Kristensen B, Waflet P, de Weck AL. Histocompatibility antigens (SLA) in swine. Possible correlation between SLA haplotype and performance of piglets. Anim Blood Grps Biochem Genet 1980; 11: 58–59.

    Google Scholar 

  45. Gautschi C, Gaillard C, Schwander B, Lazary S. Studies on possible associations between the major histocompatibility complex and reproduction traits in swine. In: 3rd world congress on genetics applied to livestock production. Lincoln, 1986; 12: 70–75.

    Google Scholar 

  46. Renard C, Bolet G, Dando P, Vaiman M. Effect of SLA haplotypes on birth and weaning weight and on deficit of homozygotes in Meishan pigs. 17ème Journée de la recherche porcine en France. Institut Technique du Pore, 1985; pp.105–112.

    Google Scholar 

  47. Rothschild MF, Renard C, Legault C, Vaimann M. Effect of SLA haplotypes on birth and weaning weight and on deficit of homozygotes in Meishan pigs. Anim Genet 1987; 18: 33–34 (Abstract).

    Google Scholar 

  48. Rothschild MF, Renard C, Bolet G, Dando P, Vaiman M. Effect of swine lymphocyte antigen haplotypes on birth and weaning weights in pigs. Anim Genet 1986; 17: 267–272.

    Article  PubMed  CAS  Google Scholar 

  49. Awdeh ZL, Raum D, Yunis EJ, Alper CA. Extended HLA/complement allele haplotypes: evidence for Tit-like complex in man. Proc Natl Acad Sci USA 1983; 80: 259–263.

    Article  PubMed  CAS  Google Scholar 

  50. Seitz A W, Bennett D. Transmission distortion of t-haplotypes is due to interactions between meiotic partners. Nature 1985; 313: 143–144.

    Article  PubMed  CAS  Google Scholar 

  51. Philipsen M, Kristensen B. Preliminary evidence of segregation distortion in the SLA system. Anim Blood Grps Biochem Genet 1985; 16: 125–133.

    Article  CAS  Google Scholar 

  52. Kristjanson FK. Transferrin types and reproductive performance in the pig. J Reprod Ferril 1964; 8: 311–317.

    Article  Google Scholar 

  53. Weitkamp LR, Schacter BZ. Transferrin and HLA: spontaneous abortion, neural tube defects, and natural selection. N Eng J Med 1985; 313: 925–932.

    Article  CAS  Google Scholar 

  54. Ghani AM, Gill TJ III, Kunz HW, Misra DN. Elicitation of the maternal antibody response to the fetus by a broadly shared MHC class I antigenic determinant. Transplantation 1984; 37: 187–194.

    Article  PubMed  CAS  Google Scholar 

  55. Macpherson TA, Ho HN, Kunz HW, Gill TJ III. Localization of the Pa antigen on the placenta of the rat. Transplantation 1986; 41: 392–394.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 The Royal College of Obstetricians and Gynaecologists

About this chapter

Cite this chapter

Renard, C. (1988). Effects of feto-maternal major histocompatibility differences on litter size in pigs. In: Sharp, F., Beard, R.W. (eds) Early Pregnancy Loss. Springer, London. https://doi.org/10.1007/978-1-4471-1658-5_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-1658-5_12

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1660-8

  • Online ISBN: 978-1-4471-1658-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics