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Radiobiology in Radiotherapy pp 81–93Cite as

Low Dose Rate in Clinical Radiotherapy

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Abstract

The radiobiological considerations underlying the cytotoxicity of low-dose-rate irradiation have been discussed in the preceding chapter. In summary they consist of repair during irradiation, which decreases cytotoxicity, and cell cycle progression which would be expected to increase cytotoxicity by virtue of resistant surviving cells moving into a more sensitive phase of the cell cycle (Table 9.1). Proliferation during irradiation may reduce the effects of low-dose-rate treatment. However, the important factor restricting repopulation is the overall treatment duration, and in many clinical examples this may be shorter after continuous low-dose-rate radiotherapy than after fractionated treatment at conventional dose rate.

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References

  • Awwad HK, Burgers JMV (1976) Studies in dose-time volume relationships in bladder and tongue radium implants. Clin Radiol 27: 443–448

    Article  PubMed  CAS  Google Scholar 

  • Awwad HK, Burgers JMV, Marcuse HR (1974) The influence of tumour dose specification on the early clinical results of interstitial tongue implants. Radiology 110: 177–182

    PubMed  CAS  Google Scholar 

  • Barendsen GW (1982) Dose fractionation, dose rate and iso-effect relationships for normal tissue response. Int J Radiat Oncol Biol Phys 9: 1981–1997

    Google Scholar 

  • Bates TD, Berry RG (1978) High dose-rate after-loading in the treatment of cancer of the uterus. Br J Radiol [Special Report]: 17

    Google Scholar 

  • Burgers JMV, Awwad HK, Van der Laarse R (1985) Relation between local cure and dose-time volume factors in interstitial implants. Int J Radiat Oncol Biol Phys 11: 715–723

    Article  PubMed  CAS  Google Scholar 

  • Corner GA, Kirk J, Perry AM (1982) Low dose-rate afterloading techniques: choice of dose and time. Clin Radiol 33: 145–147

    Article  PubMed  CAS  Google Scholar 

  • Curtis SB (1986) Lethal and potentially lethal lesions induced by radiation — a unified repair model. Radiat Res 106: 252–270

    Article  PubMed  CAS  Google Scholar 

  • Dale RG (1985) The application of the linear-quadratic dose-effect equation to fractionated and protracted radiotherapy. Br J Radiol 58: 515–528

    Article  PubMed  CAS  Google Scholar 

  • Ellis F (1968) The relationship of biological effect to dose-time-fractionation factors in radiotherapy. Curr Top Radiat Res 4: 357–397

    Google Scholar 

  • Giles GM, Brady LW (1986) 125-Iodine implantation after lymphadenectomy in early carcinoma of the prostate. Int J Radiat Oncol Biol Phys 12: 2117–2125

    Google Scholar 

  • Gonzalez D, Breur K, Van der Schueren E (1980) Preliminary results in advanced head and neck cancer with radiotherapy by multiple fractions a day. Clin Radiol 30: 417–421

    Article  Google Scholar 

  • Gutin PH, Phillips TL, Hosobuchi Y et al. (1981) Permanent and removable implants for the brachytherapy of brain tumours. Int J Radiat Oncol Biol Phys 7: 1371–1381

    Article  PubMed  CAS  Google Scholar 

  • Hall EJ (1972) Radiation dose-rate: a factor of importance in radiobiology and radiotherapy. Br J Radiol 45: 81–97

    Article  PubMed  CAS  Google Scholar 

  • Hall EJ (1978) The promise of low dose rate: has it been realized? Int J Radiat Oncol Biol Phys 4: 749–750 (editorial)

    Google Scholar 

  • Hall EJ, Bedford JS, Oliver R (1966) Extreme hypoxia: its effect on survival of mammalian cells irradiated at high and low dose-rates. Br J Radiol 39: 302–307

    Article  PubMed  CAS  Google Scholar 

  • Hilaris BS, Whitmore WF, Batata MA, Barzell W, Tokita N (1978) 125I implantation of the prostate: dose-response considerations. Front Radiat Ther Oncol 12: 82–90

    Google Scholar 

  • Joslin CA, Sharma SC (1984) Brachytherapy 1984. Nucleotron Trading BV, The Netherlands Joslin CAF, Smith CW, Mallik A (1972) The treatment of cervix cancer using high activity 60Co sources. Br J Radiol 45: 257–270

    Article  Google Scholar 

  • Kim J, Hilaris B (1975) Iodine-125 source in interstitial tumor therapy. Am J Roentgenol Radium Ther Nuc Med 123: 163–169

    CAS  Google Scholar 

  • Kirk J, Gray WM, Watson ER (1972) Cumulative radiation effect. II. Continuous radiation therapy-long-lived sources. Clin Radiol 23: 93–105

    Article  PubMed  CAS  Google Scholar 

  • Lee KH, Kagan AR, Nussbaum H, Wollin M, Winkley JH, Norman A (1976) Analysis of dose, dose-rate and treatment time in the production of injuries by radium treatment for cancer of the uterine cervix. Br J Radiol 49: 430–440

    Article  PubMed  CAS  Google Scholar 

  • Liversage WE (1969) A general formula for equating protracted and acute regimes of radiation. Br J Radiol 42: 432–440

    Article  PubMed  CAS  Google Scholar 

  • McWhirter R (1936) 13th annual report of the British Empire Cancer Campaign. London, pp 131–144

    Google Scholar 

  • Mitchell JS (1960) Studies in radiotherapeutics. Blackwell, Oxford Orton CG (1974) Time-dose factors (TDFs) in brachytherapy. Br J Radiol 47: 603–607

    Google Scholar 

  • Orton CG, Ellis F (1973) A simplification in the use of the NSD concept in practical radiotherapy. Br J Radiol 46: 529–537

    Article  PubMed  CAS  Google Scholar 

  • Paterson R (1952) Studies in optimum dosage. Br J Radiol 25: 505–516

    Article  PubMed  CAS  Google Scholar 

  • Paterson R (1963) The treatment of malignant disease by radiotherapy, 2nd edn. Williams and Wilkins, Baltimore

    Google Scholar 

  • Pierquin B, Chassagne D, Baillet F, Paine CH (1973) Clinical observations on the time factors in interstitial radiotherapy using iridium-192. Clin Radiol 24: 506–509

    Article  PubMed  CAS  Google Scholar 

  • Pierquin BM, Mueller WK, Baillet F (1978) Low dose rate irradiation of advanced head and neck cancers: present status. Int J Radiat Oncol Biol Phys 4: 565–572

    Article  PubMed  CAS  Google Scholar 

  • Pierquin B, Calitchi E, Mazeron JJ, Le Bourgeois JP, Leung S (1985) A comparison between low dose rate radiotherapy and conventionally fractionated irradiation in moderately extensive cancers of the oropharynx. Int J Radiat Oncol Biol Phys 11: 431–439

    Article  PubMed  CAS  Google Scholar 

  • Regaud C (1922) Distribution chronologique rationelle d’un traitement de cancer epithelial par les radiations. Compt Rend Soc de Biol 86: 1085–1088

    Google Scholar 

  • Sherrah-Davies E (1985) Morbidity following low-dose-rate electron therapy for cervical cancer. Clin Radiol 36: 131–139

    Article  PubMed  CAS  Google Scholar 

  • Snelling MD, Lambert HE, Yarnold JR (1979) The treatment of carcinoma of the cervix and endometrium using the cathetron at the Middlesex Hospital. Clin Radiol 30: 253–258

    Article  PubMed  CAS  Google Scholar 

  • Thames HD (1985) An “incomplete-repair” model for survival after fractionated and continuous irradiations. Int J Radiat Biol 47: 319–339

    Article  CAS  Google Scholar 

  • Turesson I, Notter G, Wickstrom I, Johansson K-A, Eklund S (1984) The influence of irradiation time per treatment session on acute and late skin reactions: a study on human skin. Radiother Oncol 2: 235–245

    Article  PubMed  CAS  Google Scholar 

  • Wilkinson JM, Hendry JH, Hunter RD (1980) Dose-rate considerations in the introduction of low-dose-rate afterloading intracavitary techniques for radiotherapy. Br J Radiol 53: 890–893

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. A. Horwich
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  2. P. Blake
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  3. G. G. Steel
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Editor information

Editors and Affiliations

  1. University of Cambridge School of Clinical Medicine, Department of Clinical Oncology and Radiotherapeutics, Addenbrooke’s Hospital, Hills Road, CB2 2QQ, Cambridge, UK

    Norman M. Bleehen FRCP, FRCR, Honorary FACR (Cancer Research Campaign Professor of Clinical Oncology, Honorary Director MRC Clinical Oncology and Radiotherapeutics Unit) (Cancer Research Campaign Professor of Clinical Oncology, Honorary Director MRC Clinical Oncology and Radiotherapeutics Unit)

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© 1988 Springer-Verlag Berlin Heidelberg

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Horwich, A., Blake, P., Steel, G.G. (1988). Low Dose Rate in Clinical Radiotherapy. In: Bleehen, N.M. (eds) Radiobiology in Radiotherapy. Springer, London. https://doi.org/10.1007/978-1-4471-1603-5_9

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  • DOI: https://doi.org/10.1007/978-1-4471-1603-5_9

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1605-9

  • Online ISBN: 978-1-4471-1603-5

  • eBook Packages: Springer Book Archive

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