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Principles of Fractionation in Radiotherapy

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Abstract

“Differing fractionation schedules can be considered as a modality in the same sense as high LET radiation, sensitizers or biological modifiers: they might increase the probability of tumour control, decrease effects on normal tissues, or combine optimally with other modalities. In addition, fractionation is the backbone of all research in radiation therapy, since some time-dose regimen must be chosen any time another modality is superimposed”.(Cox 1985)

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References

  • Cox JD (1985) Large-dose fractionation (hypofractionation). Cancer [Suppl] 55: 2105–2111

    CAS  Google Scholar 

  • Fowler JF (1983) Fractionation and therapeutic gain. In: Steel GG, Adams GE, Peckham MJ (eds) The biological basis of radiotherapy. Elsevier, Amsterdam, pp 181–194

    Google Scholar 

  • Fowler JF (1984a) Review: total doses in fractionated radiotherapy: implications of new radiobiological data. Int J Radiat Biol 46: 103–120

    Article  CAS  Google Scholar 

  • Fowler JF (1984b) Fractionated radiotherapy after Strandqvist. Acta Radiol [Oncol] 23: 209–216

    Article  CAS  Google Scholar 

  • Fowler JF (1984c) Non-standard fractionation in radiotherapy (guest editorial). Int J Radiat Oncol Biol Phys 10: 755–759

    Article  PubMed  CAS  Google Scholar 

  • Fowler JF (1986a) Potential for increasing the differential response between tumours and normal tissues: can proliferation rate be used? Int J Radiat Oncol Biol Phys 12: 641–645

    Article  PubMed  CAS  Google Scholar 

  • Fowler JF (1986b) “Fading times” required for apparently complete repair in irradiated tissues assuming the linear quadratic model of dose response. Int J Radiat Biol 50: 601–607

    Google Scholar 

  • Hendry JH, Thames HD (1987) Fractionation in radiotherapy. Churchill Livingstone, Edinburgh Orton CG, Ellis F (1973) A simplification in the use of the NSD concept in practical radiotherapy. Br J Radiol 46: 529–537

    Google Scholar 

  • Peters LJ, Ang KK (1986) In: Withers HR, Peters LJ (eds) Innovations in radiation oncology. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Saunders MI, Dische S (1986) Radiotherapy employing three fractions in each day over a continuous period of 12 days. Br J Radiol 59: 523–525

    Article  PubMed  CAS  Google Scholar 

  • Singh K (1978) Two regimes with the same TDF but differing morbidity used in the treatment of Stage III carcinoma of the cervix. Br J Radiol 51: 357–362

    Article  PubMed  CAS  Google Scholar 

  • Svoboda VHJ (1978) Further experience with radiotherapy by multiple daily sessions. Br J Radiol 51: 363–369

    Article  PubMed  CAS  Google Scholar 

  • Thames HD, Withers HR, Peters LJ, Fletcher GH (1982) Changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships. Int J Radiat Oncol Biol Phys 8: 219–226

    Article  PubMed  Google Scholar 

  • Thames HD, Peter LJ, Wither HR, Fletcher GH (1983) Accelerated fractionation vs hyperfractionation: rationales for several treatments per day. Int J Radiat Oncol Biol Phys 9: 127–138

    PubMed  Google Scholar 

  • Trott KR, Kummermehr J (1985) What is known about tumour proliferation rates to choose between accelerated fractionation or hyperfractionation? Radiother Oncol 3: 1–9

    Article  PubMed  CAS  Google Scholar 

  • Turesson I, Notter G (1984a) The influence of fraction size in radiotherapy on the late normal tissue reaction. 1. Comparison of the effects of daily and once-a-week fractionation on human skin. Int J Radiat Oncol Biol Phys 10: 593–594

    Article  PubMed  CAS  Google Scholar 

  • Turesson I, Notter G (1984b) The influence of fraction size in radiotherapy on the late normal tissue reaction. 2. Comparison of the effects of daily and twice-a-week fractionation on human skin. Int J Radiat Oncol Biol Phys 10: 599–606

    Article  PubMed  CAS  Google Scholar 

  • van der Schueren E, Ang KK, Horiot JC, Gonzalez DG, Glabbeke M van, de Pauw M (1985) Concentrated radiotherapy schedules: role of repair and repopulation. In: Plenary session proceedings, 16th international congress of radiology, Hawaii, USA, 8–12 July, pp 99–104

    Google Scholar 

  • Wang CC (1985) Accelerated fractionation. In: Plenary session proceedings, 16th international congress of radiology, Hawaii, USA, 8–12 July, pp 105–108

    Google Scholar 

  • Williams MV, Denekamp J, Fowler JF (1985) A review of α/β ratios for experimental tumours: implications for clinical studies of altered fractionation. Int J Radiat Oncol Biol Phys 11: 87–96

    Article  PubMed  CAS  Google Scholar 

  • Wilson GD, McNally NJ, Dunphy E, Karcher H, Pfranger R (1985) The labelling index of human and mouse tumours assessed by bromodeoxyuridine staining in vivo and in vitro and by flow cytometry. Cytometry 6: 641–647

    Article  PubMed  CAS  Google Scholar 

  • Withers HR, Thames HD, Peters LJ (1982) Differences in the fractionation response of acutely and late-responding tissues. In: Kaercher KH, Kogelnick HD, Reinartz G (eds) Progress in radio-oncology, vol 2. Raven Press, New York, pp 287–296

    Google Scholar 

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© 1988 Springer-Verlag Berlin Heidelberg

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Fowler, J.F. (1988). Principles of Fractionation in Radiotherapy. In: Bleehen, N.M. (eds) Radiobiology in Radiotherapy. Springer, London. https://doi.org/10.1007/978-1-4471-1603-5_6

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  • DOI: https://doi.org/10.1007/978-1-4471-1603-5_6

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1605-9

  • Online ISBN: 978-1-4471-1603-5

  • eBook Packages: Springer Book Archive

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