Non-Curative Radiotherapy for Bone Metastases

  • M. E. B. Powell
  • P. J. Hoskin
Part of the Focus on Cancer book series (3292)


Bone metastases account for more than 95% of malignant bone tumours. Although virtually all cancers can give rise to bone metastases it is carcinoma of the breast, prostate, bronchus and kidney that show a particular propensity for dissemination to bone and may be present in up to 50% of patients with these malignancies.


Bone Metastasis Pathological Fracture Spinal Cord Compression Metastatic Prostate Cancer Metastatic Bone Disease 
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  1. 1.
    Mundy GR, Boyce BF, Yoneda T (1994) Mechanisms of osteolytic bone destruction. In: Diel JS, Kaufmann M, Bastert G (eds) Metastatic bone disease: fundamental and clinical aspects. Springer-Verlag, Heidelberg, pp 86–94.Google Scholar
  2. 2.
    Boyce P, Chen H (1994) Normal bone remodelling and metastatic bone disease. In: Diel JS, Kaufmann M, Bastert G (eds) Metastatic bone disease: fundamental and clinical aspects. Springer-Verlag, Heidelberg, pp 46–58.Google Scholar
  3. 3.
    Carter RL (1985) Patterns and mechanisms of localised bone invasion by tumours: studies with squamous carcinomas of the head and neck. Crit Rev Clin Lab Sci 22:275–315.PubMedCrossRefGoogle Scholar
  4. 4.
    Twycross R (1983) Analgesics and relief of bone pain. In: Stoll BA, Parbhoo S (eds) Bone metastases: monitoring and treatment. Raven, New York, pp 289–310.Google Scholar
  5. 5.
    Stoll BA (1983) Natural history, prognosis and staging of bone metastasis. In: Stoll BA, Parbhoo S (eds) Bone metastases: monitoring and treatment. Raven, New York, pp 1–20.Google Scholar
  6. 6.
    Burch HA (1944) Osseous metastases from graded cancers of the breast with particular reference to Roentgen treatment. Am J Roentgenol Radium Ther 52:1–23.Google Scholar
  7. 7.
    Garmatis CJ, Chu F, Dwyer AJ (1978) The effectiveness of radiation therapy in the treatment of bone metastases from breast cancer. Radiology 16:235–237.Google Scholar
  8. 8.
    Hoskin PJ, Ford HT, Harmer CL (1989) Hemibody irradiation for metastatic bone pain in two histologically distinct groups of patients. Clin Oncol 1:67–69.CrossRefGoogle Scholar
  9. 9.
    Poulsen HS, Nielsen OS, Klee M et al. (1989) Palliative irradiation of bone metastases. Cancer Treat Rev 16:41–48.PubMedCrossRefGoogle Scholar
  10. 10.
    Hoskin PJ (1989) Scientific and clinical aspects of radiotherapy in the relief of bone pain. Cancer Surv 7:69–86.Google Scholar
  11. 11.
    Nielsen OS, Munro AJ, Tannock IF (1991) Bone metastases: pathophysiology and management policy. J Clin Oncol 9:509–524.PubMedGoogle Scholar
  12. 12.
    Tong D, Gillick L, Hendrickson FR (1982) The palliation of symptomatic osseous metastases. Final results of the study by the radiation therapy oncology group. Cancer 50:893–899.PubMedCrossRefGoogle Scholar
  13. 13.
    Blitzer PH (1985) Reanalysis of the RTOG study of the palliation of symptomatic osseous metastasis. Cancer 55:1468–1472.PubMedCrossRefGoogle Scholar
  14. 14.
    Price P, Hoskin PJ, Easton D et al. (1986) Prospective randomised trial of single and multi fraction radiotherapy in the treatment of painful bony metastases. Radiother Oncol 6:247–255.PubMedCrossRefGoogle Scholar
  15. 15.
    Cole DJ (1989) A randomized trial of a single treatment versus conventional fractionation in the palliative radiotherapy of bone metastases. Clin Oncol 1:59–62.CrossRefGoogle Scholar
  16. 16.
    Hoskin PJ, Price P, Easton D et al. (1992) Prospective randomised trial of 4 Gy or 8 Gy single doses in the treatment of metastatic bone pain. Radiother Oncol 23:74–78.PubMedCrossRefGoogle Scholar
  17. 17.
    Hanks GW, Hoskin PJ (1986) Pain control in advanced cancer: Pharmacological methods. J R Coll Phys Lond 20:276–281.Google Scholar
  18. 18.
    Bates T (1992) A review of local radiotherapy in the treatment of bone metastases and cord compression. Int J Radiat Oncol Biol Phys 23:217–221.PubMedCrossRefGoogle Scholar
  19. 19.
    Pigott KH, Baddeley H, Maher EJ (1994) Pattern of disease in spinal cord compression on MRI scan and implications for treatment. Clin Oncol 6:7–10.CrossRefGoogle Scholar
  20. 20.
    Findlay GFG (1984) Adverse effects of the management of malignant spinal cord compression. J Neurol Neurosurg Psychiat 47:761–768.PubMedCrossRefGoogle Scholar
  21. 21.
    Findlay GFG, Sandeman DR, Buxton P (1988) The role of needle biopsy in the management of malignant spinal cord compression. Br J Neurosurg 2:479–484.PubMedCrossRefGoogle Scholar
  22. 22.
    Hoskin PJ (1994) Changing trends in palliative radiotherapy. In: Tobias J, Thomas PRM (eds) Current radiation oncology, vol 1. Edward Arnold, London, pp 342–364.Google Scholar
  23. 23.
    Salazar OM, Rubin P, Hendrickson FR et al. (1986) Single dose half body irradiation for palliation of multiple bone metastases from solid tumours. Cancer 58:29–36.PubMedCrossRefGoogle Scholar
  24. 24.
    Maclennan I, Hosni MS, Rubin P (1989) Sequential hemibody radiotherapy in poor prognosis localised adenocarcinoma of the prostate gland: a preliminary study of the RTOG. Int J Radiat Oncol Biol Phys 16:215–218.PubMedCrossRefGoogle Scholar
  25. 25.
    Quasim MM (1989) Half body irradiation in metastatic carcinomas. Clin Radiol 35:215–219.Google Scholar
  26. 26.
    Poulter CA, Cosmatos D, Rubin P et al. (1992) A report of the RTOG 8206: A phase III study of whether the addition of a single dose hemibody irradiation to standard fractionated local field irradiation is more effective than local field irradiation alone in the treatment of symptomatic osseous metastases. Int J Radiat Oncol Biol Phys 23:207–214.PubMedCrossRefGoogle Scholar
  27. 27.
    Zelefsky MJ, Scher HI, Forman JD et al. (1989) Palliative hemiskeletal irradiation for widespread metastatic prostate cancer: a comparison of single dose and fractionated regimens. Int J Radiat Oncol Biol Phys 17:1281–1285.PubMedCrossRefGoogle Scholar
  28. 28.
    Brown AP, Greening WP, McReady VR et al. (1984) Radioiodine treatment of metastatic thyroid carcinoma: the Royal Marsden Hospital experience. Br J Radiol 57:323–327.PubMedCrossRefGoogle Scholar
  29. 29.
    O’Connell MEA, Flower M, Hinton PJ et al. (1993) Radiation dose assessment in radioiodine therapy. Dose-response relationships in differentiated thyroid carcinoma using quantitative scanning and PET. Radiother Oncol 28:16–26.PubMedCrossRefGoogle Scholar
  30. 30.
    Burnet NG, Williams G, Howard N (1990) Phosphorus-32 for intractable bony pain from carcinoma of the prostate. Clin Oncol 2:220–223.CrossRefGoogle Scholar
  31. 31.
    Robinson RG, Blake GM, Preston DF et al. (1989) Treatment results and kinetics in patients with painful metastatic prostate and breast cancer in bone. Radiographics 9:271–281.PubMedGoogle Scholar
  32. 32.
    Quilty PM, Kirk D, Bolger JJ et al. (1994) A comparison of the palliative effects of strontium-89 and external beam radiotherapy in metastatic prostate cancer. Radiother Oncol 31:33–40.PubMedCrossRefGoogle Scholar
  33. 33.
    Porter AT, McEwan AJB, Powe JE et al. (1993) Results of a randomized phase III trial to evaluate the efficacy of strontium-89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer. Int J Radiat Oncol Biol Phys 25:805–813.PubMedCrossRefGoogle Scholar
  34. 34.
    Turner JH, Claringbold PG (1991) A phase II study of treatment of painful multifocal skeletal metastases with single and repeated dose samarium-153 ethylenediaminetetramethylene phosphate. Eur J Cancer 27:1084–1086.PubMedCrossRefGoogle Scholar
  35. 35.
    Holmes R (1993) Radiopharmaceuticals in clinical trials. Semin Oncol 20(suppl 2):22–26.PubMedGoogle Scholar
  36. 36.
    Madsen EJ (1983) Painful bone metastasis: efficacy of radiotherapy assessed by the patients: a randomised trial comparing 4 Gy x 6 versis 1-Gy x 2. Int J Radiat Oncol Biol Phys 9:1775–1779.PubMedGoogle Scholar
  37. 37.
    Okawa T, Kita M, Goto M et al. (1988) Randomized prospective clinical study of small, large and twice-a-day fraction radiotherapy for painful bone metastases. Radiother Oncol 13:99–104.PubMedCrossRefGoogle Scholar
  38. 38.
    Reddy S, Hendrickson FR, Hocksema J (1983) The role of radiation therapy in the palliation of metastatic genitourinary tract carcinomas. A study of the Radiation Therapy Oncology Group. Cancer 52:25–29.PubMedCrossRefGoogle Scholar
  39. 39.
    Rowland CG, Bullimore JA, Smith PJB, Roberts JBM (1981) Half body irradiation in the treatment of metastatic prostatic carcinoma. Br J Urol 53:628–629.PubMedCrossRefGoogle Scholar
  40. 40.
    Nag S, Shah V (1986) Once-a-week lower hemibody irradiation for metastatic cancers. Int J Radiat Oncol Biol Phys 12:1003–1005.PubMedCrossRefGoogle Scholar
  41. 41.
    Tennvall J, Darte L, Lundgren R, el Hassan AM (1988) Palliation of multiple bone metastases from prostate cancer with strontium-89. Acta Oncol 27:365–369.PubMedCrossRefGoogle Scholar
  42. 42.
    Laing AH, Ackery DM, Bayly RJ et al. (1991) Strontium-89 chloride for pain palliation in prostatic skeletal malignancy. Br J Radiol 64:816–822.PubMedCrossRefGoogle Scholar
  43. 43.
    Lewington VJ, McEwan AJB, Ackery DM et al. (1991) A prospective randomised double-blind study to examine the efficacy of strontium-89 in pain palliation in patients with advanced prostate cancer metastatic to bone. Eur J Cancer 27:954–958.PubMedCrossRefGoogle Scholar

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© Springer-Verlag London Limited 1998

Authors and Affiliations

  • M. E. B. Powell
  • P. J. Hoskin

There are no affiliations available

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