Abstract
It is probably not an incorrect generalisation to state that current methods of treatment of the lymphomas and lymphocytic leukaemias have met with limited success. In this chapter we will not discuss the details of treatments but will consider why treatment may be unsuccessful and will also discuss the potential of contemporary therapeutic approaches.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aggarwal BB, Kohr WJ, Hass PE et al. (1985) Human tumor necrosis factor. Production purification and characterization. J Biol Chem 260: 2345–2354
Aiuti F, Businco L, Fiorilli M et al. (1983) Thymopoietin pentapeptide treatment of primary immunodeficiencies. Lancet I: 551–555
Baglioni C, McCandless S, Tavernier J, Fiers W (1985) Binding of human tumor necrosis factor to high affinity receptors on HeLa and lymphoid cells sensitive to growth inhibition. J Biol Chem 260: 13395–13397
Baldwin RW, Byers VS (1986) Monclonal antibodies in cancer treatment. Lancet I: 603–605
Baumgartner C, Bleher EA, Brum del Re G et al. (1984) Autologous bone marrow transplantation in the treatment of children and adolescents with advanced malignant tumors. Med Paediatr Oncol 12: 104–111
Billard C, Sigaux F, Castaigne S et al. (1986) Treatment of hairy cell leukemia with recombinant alpha interferon. II. In vivo down-regulation of alpha interferon receptors on tumor cells. Blood 67: 821–826
Bindon C, Czernecki M, Ruell P et al. (1983) Clearance rates and systemic effects of intravenously administered interleukin 2 (IL-2) containing preparations in human subjects. Br J Cancer 47: 123–133
Bunn PA Jr, Foon KA, Ihde DC et al. (1984) Recombinant leukocyte A interferon: an active agent in advanced cutaneous T-cell lymphomas. Ann Intern Med 101: 484–487
Carswell EA, Old LJ, Kassel RI, Green S, Fiore N, Williamson B (1975) An endotoxin-induced serum factor that causes necrosis of tumours. Proc Natl Acad Sci USA 72: 3666–3670
Chirigos MA, Talmadge JE (1985) Immunotherapeutic agents; their role in cellular immunity and their therapeutic potential. Semin Immunopathol 8: 327–346
Cohen DJ, Loertscher R, Rubin MF et al. (1984) Cyclosporine: a new immunosuppressive agent for organ transplantation. Ann Intern Med 101: 667–682
Cohen MH, Chretien PB, Ihde DC et al. (1979) Thymosin fraction V and intensive combination therapy. Prolonging the survival of patients with small cell lung cancer. J Am Med Assoc 241: 1813–1815
De Vita VT, Jaffe ES, Hellman S (1985) Hodgkin’s disease and the non-Hodgkin’s lymphomas. In: De Vita VT, Hellman S, Rosenberg SA (eds) Cancer. Principles and practice of oncology, 2nd edn. Lippincott, Philadelphia, pp 1623–1709
Eberlein TJ, Rosenstein M, Rosenberg SA (1982) Regression of a disseminated syngeneic solid tumor by systemic transfer of lymphoid cells expanded in interleukin 2. J Exp Med 156: 385–397
Editorial (1985) Cyclosporin in autoimmune disease. Lancet I: 909–911
Fernandez-Cruz E, Halliburton B, Feldman JD (1979) In vivo elimination by specific effector cells of an established syngeneic rat Moloney virus-induced sarcoma. J Immunol 123: 1772–1777
Fernandez-Cruz E, Woda BA, Feldman JD (1980) Elimination of syngeneic sarcomas in rats by subset of T lymphocytes. J Exp Med 152: 823–841
Fischinger PJ, Robey WG, Koprowski H, Gallo RC, Bolognesi DP (1985) Current status and strategies for vaccines against diseases induced by human T-cell lymphotropic retroviruses (HTLV- I, -II, -III). Cancer Res (Suppl 9) 45: 4694s–4699s
French Cooperative Group on Chronic Lymphocytic Leukaemia (1986) Effectiveness of “CHOP” regimen in advanced untreated chronic lymphocytic leukaemia. Lancet I: 1346–1349
Gale RP, Foon K (1985) Chronic lymphocytic leukemia. Recent advances in biology and treatment. Ann Intern Med 103: 101–120
Grever MR, Wilson HE, Kraut EH et al. (1981) Deoxycoformycin in the treatment of refractory chronic lymphocytic leukemia. Proc Am Assoc Cancer Res 22: 487
Grever MR, Leiby EH, Kraut EH et al. (1985) Low-dose deoxycoformycin in lymphoid malignancy. J Clin Oncol 3: 1196–1201
Gutterman JU, Fine S, Quesada J et al. (1982) Recombinant leukocyte A interferon: pharmacokinetics, single-dose tolerance, and biologic effects in cancer patients. Ann Intern Med 96: 549–556
Hirshaut Y, Slovin SF (1985) Harnessing T-lymphocytes for human cancer immunotherapy. Cancer 56: 1366–1373
Horning SJ, Merigan TC, Krown S et al. (1985) Human interferon a in malignant lymphoma and Hodgkin’s disease. Results of the American Cancer Society Trial. Cancer 56: 1305–1310
Hu E, Trela M, Thompson J et al. (1985) Detection of B-cell lymphoma in peripheral blood by DNA hybridization. Lancet II: 1092–1095
Kirch ME (1984) Approaches to cancer therapy using monoclonal antibodies. In: Wright GL (ed) Monoclonal antibodies and cancer. (Immunology Series 23.) Marcel Dekker, New York, pp 325–360
Klaus GGB, Chisholm PM (1986) Does cyclosporine act in vivo as it does in vitro? Immunol Today 7: 100–103
Krönke M, Leonard WJ, Depper JM et al. (1984) Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc Natl Acad Sci (USA) 81: 5214–5218
Lauria F, Raspadori D, Tura S (1984) Effect of a thymic factor on T lymphocytes in B cell chronic lymphocytic leukemia: in vitro and in vivo studies. Blood 64: 667–671
Lifson JD, Benike CJ, Mark DF, Koths K, Engelman EG (1984) Human recombinant interleukin-2 partly reconstitutes deficient in-vitro immune responses of lymphocytes from patients with AIDS. Lancet I: 698–702
Mason DW, Thorpe PE, Ross WCJ (1982) Elimination of leukemic cells from rodent bone marrow in vitro with antibody ricin conjugates: implications for autologous bone marrow transplantation in man. Cancer Surv 1: 389
Meeker TC, Loweder J, Maloney DG et al. (1985) A clinical trial of anti-idiotype therapy for B cell malignancy. Blood 65: 1349–1363
Miller RA, Levy R (1981) Response of cutaneous T cell lymphoma to therapy with hybridoma monoclonal antibody. Lancet II: 226–230
Miller RA, Maloney DG, Warnke R, Levy R (1982) Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody. N Engl J Med 306: 517–522
Muirhead M, Martin PJ, Torok-Storb B, Uhr JW, Vitetta ES (1983) Use of antibody-ricin A-chain conjugate to delete neoplastic B cells from bone marrow. Blood 62: 327–332
Nadler LM, Stashenko P, Hardy R et al. (1980) Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma-associated antigen. Cancer Res 40: 3147–3154
Nadler LM, Takvorian T, Botnick L et al. (1984) Anti-Bl monoclonal antibody and complement treatment in autologous bone-marrow transplantation for relapsed B-cell non-Hodgkin’s lymphoma. Lancet II: 427–431
Oscier DG, Catovsky D, Errington RD et al. (1984) Splenic irradiation in B-prolymphocytic leukaemia. Br J Haematol 48: 577–584
Pennica D, Nedwin GE, Hayflick JS et al. (1984) Human tumour necrosis factor; precursor structure, expression and homology to lymphotoxin. Nature 312: 724–729
Porzsolt F, Thoma J, Unsold M et al. (1985) Platelet-adjusted IFN dosage in the treatment of advanced hairy cell leukemia. Blut 51: 73–82
Primus FJ, De Land FH, Goldenberg DM (1984) Monoclonal antibodies for the detection of cancer. In: Wright GL (ed) Monoclonal antibodies and cancer. (Immunology Series 23.). Marcel Dekker, New York, pp 305–323
Quesada JR, Reuben J, Manning JT, Hersh EM, Gutterman JU (1984) Alpha interferon for induction of remission in hairy cell leukemia. N Engl J Med 310: 15–18
Rayner AA, Grimm EA, Lotze MT, Chu EW, Rosenberg SA (1985) Lymphokine-activated killer (LAK) cells. Analysis of factors relevant to the immunotherapy of human cancer. Cancer 55: 1327–1333
Reisfeld RA, Cheresh DA (1985) Human tumour-associated antigens: targets for monoclonal antibody-mediated cancer therapy. Cancer Surv 4: 271–299
Ritz J, Schlossman SF (1982) Utilisation of monoclonal antibodies in the treatment of leukemia and lymphoma. Blood 59: 1–11
Robbins IH, Dennis WH, Steeves RA, Sondel PM (1984) A proposal for the addition of hyperthermia to treatment regimens for acute and chronic leukemia. J Clin Oncol 2: 1050–1056
Rosenberg SA (1985) Lymphokine-activated killer cells: a new approach to immunotherapy of cancer. J Natl Cancer Inst 75: 595–603
Rosenberg SA, Lotze MT, Muul LM et al. (1985) Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med 313: 1485–1492
Sugarman BJ, Aggarwal BB, Hass PE et al. (1985) Recombinant human tumour necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro. Science 230: 943–945
Tsujimoto M, Yip YK, Vilcek J (1985) Tumor necrosis factor: specific binding and internalisation in sensitive and resistant cells. Proc Natl Acad Sci USA 82: 7626–7630
Uhr JW (1984) Immunotoxins: harnessing nature’s poisons. J Immunol 133: i–x
Waldmann H, Polliak A, Hale G et al. (1984) Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monclonal rat anti-human lymphocyte antibody (CAMPATH-1). Lancet II: 483–486
Waldmann TA, Davis MM, Bongiovanni KF, Korsmeyer SJ, (1985) Rearrangements of genes for the antigen receptor on T cells as markers of lineage and clonality in human lymphoid neoplasms. N Engl J Med 313: 776–783
Weiss DW (1984) Reflections on tumour origin, immunogenicity and immunotherapy. Cancer Immunol Immunother 18: 1–4
Worman CP, Catovsky D, Bevan PC et al. (1985) Interferon is effective in hairy cell leukaemia. Br J Haematol 60: 759–763
Yarchoan R, Klecker RW, Weinhold KJ et al. (1986) Administration of 3′-azido-3′-deoxythymidine, an inhibitor of HIV/LAV replication, to patients with AIDS or AIDS-related complex. Lancet I: 575–580
Yu A, Bakay B, Matsumoto S et al. (1981) The effects of deoxycoformycin (dCF) on T-cell chronic lymphocytic leukemia (CLL). Proc Am Assoc Cancer Res 22: 226
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Forbes, I.J., Leong, A.SY. (1987). Treatment, Treatment Failure and Future Possibilities. In: Essential Oncology of the Lymphocyte. Springer, London. https://doi.org/10.1007/978-1-4471-1467-3_20
Download citation
DOI: https://doi.org/10.1007/978-1-4471-1467-3_20
Publisher Name: Springer, London
Print ISBN: 978-1-4471-1469-7
Online ISBN: 978-1-4471-1467-3
eBook Packages: Springer Book Archive