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Treatment, Treatment Failure and Future Possibilities

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Book cover Essential Oncology of the Lymphocyte

Abstract

It is probably not an incorrect generalisation to state that current methods of treatment of the lymphomas and lymphocytic leukaemias have met with limited success. In this chapter we will not discuss the details of treatments but will consider why treatment may be unsuccessful and will also discuss the potential of contemporary therapeutic approaches.

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References

  • Aggarwal BB, Kohr WJ, Hass PE et al. (1985) Human tumor necrosis factor. Production purification and characterization. J Biol Chem 260: 2345–2354

    PubMed  CAS  Google Scholar 

  • Aiuti F, Businco L, Fiorilli M et al. (1983) Thymopoietin pentapeptide treatment of primary immunodeficiencies. Lancet I: 551–555

    Article  Google Scholar 

  • Baglioni C, McCandless S, Tavernier J, Fiers W (1985) Binding of human tumor necrosis factor to high affinity receptors on HeLa and lymphoid cells sensitive to growth inhibition. J Biol Chem 260: 13395–13397

    PubMed  CAS  Google Scholar 

  • Baldwin RW, Byers VS (1986) Monclonal antibodies in cancer treatment. Lancet I: 603–605

    Article  Google Scholar 

  • Baumgartner C, Bleher EA, Brum del Re G et al. (1984) Autologous bone marrow transplantation in the treatment of children and adolescents with advanced malignant tumors. Med Paediatr Oncol 12: 104–111

    Article  CAS  Google Scholar 

  • Billard C, Sigaux F, Castaigne S et al. (1986) Treatment of hairy cell leukemia with recombinant alpha interferon. II. In vivo down-regulation of alpha interferon receptors on tumor cells. Blood 67: 821–826

    PubMed  CAS  Google Scholar 

  • Bindon C, Czernecki M, Ruell P et al. (1983) Clearance rates and systemic effects of intravenously administered interleukin 2 (IL-2) containing preparations in human subjects. Br J Cancer 47: 123–133

    Article  PubMed  CAS  Google Scholar 

  • Bunn PA Jr, Foon KA, Ihde DC et al. (1984) Recombinant leukocyte A interferon: an active agent in advanced cutaneous T-cell lymphomas. Ann Intern Med 101: 484–487

    PubMed  Google Scholar 

  • Carswell EA, Old LJ, Kassel RI, Green S, Fiore N, Williamson B (1975) An endotoxin-induced serum factor that causes necrosis of tumours. Proc Natl Acad Sci USA 72: 3666–3670

    Article  PubMed  CAS  Google Scholar 

  • Chirigos MA, Talmadge JE (1985) Immunotherapeutic agents; their role in cellular immunity and their therapeutic potential. Semin Immunopathol 8: 327–346

    Article  CAS  Google Scholar 

  • Cohen DJ, Loertscher R, Rubin MF et al. (1984) Cyclosporine: a new immunosuppressive agent for organ transplantation. Ann Intern Med 101: 667–682

    PubMed  CAS  Google Scholar 

  • Cohen MH, Chretien PB, Ihde DC et al. (1979) Thymosin fraction V and intensive combination therapy. Prolonging the survival of patients with small cell lung cancer. J Am Med Assoc 241: 1813–1815

    Article  CAS  Google Scholar 

  • De Vita VT, Jaffe ES, Hellman S (1985) Hodgkin’s disease and the non-Hodgkin’s lymphomas. In: De Vita VT, Hellman S, Rosenberg SA (eds) Cancer. Principles and practice of oncology, 2nd edn. Lippincott, Philadelphia, pp 1623–1709

    Google Scholar 

  • Eberlein TJ, Rosenstein M, Rosenberg SA (1982) Regression of a disseminated syngeneic solid tumor by systemic transfer of lymphoid cells expanded in interleukin 2. J Exp Med 156: 385–397

    Article  PubMed  CAS  Google Scholar 

  • Editorial (1985) Cyclosporin in autoimmune disease. Lancet I: 909–911

    Google Scholar 

  • Fernandez-Cruz E, Halliburton B, Feldman JD (1979) In vivo elimination by specific effector cells of an established syngeneic rat Moloney virus-induced sarcoma. J Immunol 123: 1772–1777

    PubMed  CAS  Google Scholar 

  • Fernandez-Cruz E, Woda BA, Feldman JD (1980) Elimination of syngeneic sarcomas in rats by subset of T lymphocytes. J Exp Med 152: 823–841

    Article  PubMed  CAS  Google Scholar 

  • Fischinger PJ, Robey WG, Koprowski H, Gallo RC, Bolognesi DP (1985) Current status and strategies for vaccines against diseases induced by human T-cell lymphotropic retroviruses (HTLV- I, -II, -III). Cancer Res (Suppl 9) 45: 4694s–4699s

    PubMed  CAS  Google Scholar 

  • French Cooperative Group on Chronic Lymphocytic Leukaemia (1986) Effectiveness of “CHOP” regimen in advanced untreated chronic lymphocytic leukaemia. Lancet I: 1346–1349

    Google Scholar 

  • Gale RP, Foon K (1985) Chronic lymphocytic leukemia. Recent advances in biology and treatment. Ann Intern Med 103: 101–120

    PubMed  CAS  Google Scholar 

  • Grever MR, Wilson HE, Kraut EH et al. (1981) Deoxycoformycin in the treatment of refractory chronic lymphocytic leukemia. Proc Am Assoc Cancer Res 22: 487

    Google Scholar 

  • Grever MR, Leiby EH, Kraut EH et al. (1985) Low-dose deoxycoformycin in lymphoid malignancy. J Clin Oncol 3: 1196–1201

    PubMed  CAS  Google Scholar 

  • Gutterman JU, Fine S, Quesada J et al. (1982) Recombinant leukocyte A interferon: pharmacokinetics, single-dose tolerance, and biologic effects in cancer patients. Ann Intern Med 96: 549–556

    PubMed  CAS  Google Scholar 

  • Hirshaut Y, Slovin SF (1985) Harnessing T-lymphocytes for human cancer immunotherapy. Cancer 56: 1366–1373

    Article  PubMed  CAS  Google Scholar 

  • Horning SJ, Merigan TC, Krown S et al. (1985) Human interferon a in malignant lymphoma and Hodgkin’s disease. Results of the American Cancer Society Trial. Cancer 56: 1305–1310

    Article  PubMed  CAS  Google Scholar 

  • Hu E, Trela M, Thompson J et al. (1985) Detection of B-cell lymphoma in peripheral blood by DNA hybridization. Lancet II: 1092–1095

    Article  Google Scholar 

  • Kirch ME (1984) Approaches to cancer therapy using monoclonal antibodies. In: Wright GL (ed) Monoclonal antibodies and cancer. (Immunology Series 23.) Marcel Dekker, New York, pp 325–360

    Google Scholar 

  • Klaus GGB, Chisholm PM (1986) Does cyclosporine act in vivo as it does in vitro? Immunol Today 7: 100–103

    Article  Google Scholar 

  • Krönke M, Leonard WJ, Depper JM et al. (1984) Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc Natl Acad Sci (USA) 81: 5214–5218

    Article  Google Scholar 

  • Lauria F, Raspadori D, Tura S (1984) Effect of a thymic factor on T lymphocytes in B cell chronic lymphocytic leukemia: in vitro and in vivo studies. Blood 64: 667–671

    PubMed  CAS  Google Scholar 

  • Lifson JD, Benike CJ, Mark DF, Koths K, Engelman EG (1984) Human recombinant interleukin-2 partly reconstitutes deficient in-vitro immune responses of lymphocytes from patients with AIDS. Lancet I: 698–702

    Article  Google Scholar 

  • Mason DW, Thorpe PE, Ross WCJ (1982) Elimination of leukemic cells from rodent bone marrow in vitro with antibody ricin conjugates: implications for autologous bone marrow transplantation in man. Cancer Surv 1: 389

    Google Scholar 

  • Meeker TC, Loweder J, Maloney DG et al. (1985) A clinical trial of anti-idiotype therapy for B cell malignancy. Blood 65: 1349–1363

    PubMed  CAS  Google Scholar 

  • Miller RA, Levy R (1981) Response of cutaneous T cell lymphoma to therapy with hybridoma monoclonal antibody. Lancet II: 226–230

    Article  Google Scholar 

  • Miller RA, Maloney DG, Warnke R, Levy R (1982) Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody. N Engl J Med 306: 517–522

    Article  PubMed  CAS  Google Scholar 

  • Muirhead M, Martin PJ, Torok-Storb B, Uhr JW, Vitetta ES (1983) Use of antibody-ricin A-chain conjugate to delete neoplastic B cells from bone marrow. Blood 62: 327–332

    PubMed  CAS  Google Scholar 

  • Nadler LM, Stashenko P, Hardy R et al. (1980) Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma-associated antigen. Cancer Res 40: 3147–3154

    PubMed  CAS  Google Scholar 

  • Nadler LM, Takvorian T, Botnick L et al. (1984) Anti-Bl monoclonal antibody and complement treatment in autologous bone-marrow transplantation for relapsed B-cell non-Hodgkin’s lymphoma. Lancet II: 427–431

    Article  Google Scholar 

  • Oscier DG, Catovsky D, Errington RD et al. (1984) Splenic irradiation in B-prolymphocytic leukaemia. Br J Haematol 48: 577–584

    Article  Google Scholar 

  • Pennica D, Nedwin GE, Hayflick JS et al. (1984) Human tumour necrosis factor; precursor structure, expression and homology to lymphotoxin. Nature 312: 724–729

    Article  PubMed  CAS  Google Scholar 

  • Porzsolt F, Thoma J, Unsold M et al. (1985) Platelet-adjusted IFN dosage in the treatment of advanced hairy cell leukemia. Blut 51: 73–82

    Article  PubMed  CAS  Google Scholar 

  • Primus FJ, De Land FH, Goldenberg DM (1984) Monoclonal antibodies for the detection of cancer. In: Wright GL (ed) Monoclonal antibodies and cancer. (Immunology Series 23.). Marcel Dekker, New York, pp 305–323

    Google Scholar 

  • Quesada JR, Reuben J, Manning JT, Hersh EM, Gutterman JU (1984) Alpha interferon for induction of remission in hairy cell leukemia. N Engl J Med 310: 15–18

    Article  PubMed  CAS  Google Scholar 

  • Rayner AA, Grimm EA, Lotze MT, Chu EW, Rosenberg SA (1985) Lymphokine-activated killer (LAK) cells. Analysis of factors relevant to the immunotherapy of human cancer. Cancer 55: 1327–1333

    Article  PubMed  CAS  Google Scholar 

  • Reisfeld RA, Cheresh DA (1985) Human tumour-associated antigens: targets for monoclonal antibody-mediated cancer therapy. Cancer Surv 4: 271–299

    PubMed  CAS  Google Scholar 

  • Ritz J, Schlossman SF (1982) Utilisation of monoclonal antibodies in the treatment of leukemia and lymphoma. Blood 59: 1–11

    PubMed  CAS  Google Scholar 

  • Robbins IH, Dennis WH, Steeves RA, Sondel PM (1984) A proposal for the addition of hyperthermia to treatment regimens for acute and chronic leukemia. J Clin Oncol 2: 1050–1056

    Google Scholar 

  • Rosenberg SA (1985) Lymphokine-activated killer cells: a new approach to immunotherapy of cancer. J Natl Cancer Inst 75: 595–603

    PubMed  CAS  Google Scholar 

  • Rosenberg SA, Lotze MT, Muul LM et al. (1985) Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med 313: 1485–1492

    Article  PubMed  CAS  Google Scholar 

  • Sugarman BJ, Aggarwal BB, Hass PE et al. (1985) Recombinant human tumour necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro. Science 230: 943–945

    Article  PubMed  CAS  Google Scholar 

  • Tsujimoto M, Yip YK, Vilcek J (1985) Tumor necrosis factor: specific binding and internalisation in sensitive and resistant cells. Proc Natl Acad Sci USA 82: 7626–7630

    Article  PubMed  CAS  Google Scholar 

  • Uhr JW (1984) Immunotoxins: harnessing nature’s poisons. J Immunol 133: i–x

    PubMed  CAS  Google Scholar 

  • Waldmann H, Polliak A, Hale G et al. (1984) Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monclonal rat anti-human lymphocyte antibody (CAMPATH-1). Lancet II: 483–486

    Article  Google Scholar 

  • Waldmann TA, Davis MM, Bongiovanni KF, Korsmeyer SJ, (1985) Rearrangements of genes for the antigen receptor on T cells as markers of lineage and clonality in human lymphoid neoplasms. N Engl J Med 313: 776–783

    Article  PubMed  CAS  Google Scholar 

  • Weiss DW (1984) Reflections on tumour origin, immunogenicity and immunotherapy. Cancer Immunol Immunother 18: 1–4

    Article  PubMed  Google Scholar 

  • Worman CP, Catovsky D, Bevan PC et al. (1985) Interferon is effective in hairy cell leukaemia. Br J Haematol 60: 759–763

    Article  PubMed  CAS  Google Scholar 

  • Yarchoan R, Klecker RW, Weinhold KJ et al. (1986) Administration of 3′-azido-3′-deoxythymidine, an inhibitor of HIV/LAV replication, to patients with AIDS or AIDS-related complex. Lancet I: 575–580

    Article  Google Scholar 

  • Yu A, Bakay B, Matsumoto S et al. (1981) The effects of deoxycoformycin (dCF) on T-cell chronic lymphocytic leukemia (CLL). Proc Am Assoc Cancer Res 22: 226

    Google Scholar 

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© 1987 Springer-Verlag Berlin Heidelberg

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Forbes, I.J., Leong, A.SY. (1987). Treatment, Treatment Failure and Future Possibilities. In: Essential Oncology of the Lymphocyte. Springer, London. https://doi.org/10.1007/978-1-4471-1467-3_20

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  • DOI: https://doi.org/10.1007/978-1-4471-1467-3_20

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1469-7

  • Online ISBN: 978-1-4471-1467-3

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