Structural Modifications of the Arterial Wall in Hypertension

  • J.-B. Michel
  • J. L. Salzmann
  • M. Safar

Abstract

Physiological and pathological observations of the vascular system in clinical and experimental models of hypertension, normotension and cardiac insufficiency, suggest that the level of blood pressure is related directly to both primary functions of the cardiovascular system: the peripheral blood flow and filtration pressure in capillaries necessary for oxygen delivery to tissues [8,15]. For example, in spontaneously hypertensive rats, these two variables are probably in the normal range [22] which is an indication of the cardiovascular system’s ability to adopt its functional and structural parameters for survival. In human essential hypertension, cardiac output is in the normal range [3]. In experimental models, as in human beings, the homeostatic mechanisms of blood flow regulation are conserved. The adaptation of the cardiovascular system in hypertension probably is related to the minimal energy level necessary for the maintenance of a cardiovascular function compatible with survival.

Keywords

Permeability Filtration Albumin Luminal Macromolecule 

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References

  1. 1.
    Berry, CL, Greenwald SE (1976) Effects of hypertension on the static, mechanical properties and chemical composition of the rat aorta. Cardiovasc Res 10:437–451PubMedCrossRefGoogle Scholar
  2. 2.
    Carlier P, Rorive G (1985) Pathogenesis and reversibility of the aortic changes in experimental hypertension. Cardiovasc Pharmacol 7:S46-S51CrossRefGoogle Scholar
  3. 3.
    Chau NPH, Safar ME, London GM, Weiss YA (1979) Essential hypertension: an approach to clinical data by the use of models. Hypertension 2:87–97Google Scholar
  4. 4.
    Chobanian AV, Prescott MF, Haudenschild C (1984) The effects of hypertension on the arterial wall. Exp Mol Pathol 41:153–169PubMedCrossRefGoogle Scholar
  5. 5.
    Cliff WJ (1970) The aortic tunica media in aging rats. Exp Mol Pathol 13:172–189PubMedCrossRefGoogle Scholar
  6. 6.
    Furanaya M (1982) Histometrical investigations of arteries in reference to arterial hypertension. Tokohu J Exp Med 75: 388–414Google Scholar
  7. 7.
    Folkow B (1982) Physiological aspect of primary hypertension. Physiol Rev 62:347–503PubMedGoogle Scholar
  8. 8.
    Guyton AC (1980) Circulatory physiology III: arterial pressure and hypertension. Saunders, Philadelphia, pp 293–306Google Scholar
  9. 9.
    Greenwald SE, Berry CL, Ramsey RE (1985) The static elastic properties and chemical composition of the rat aorta in spontaneously induced hypertension: the effect of an antihypertensive drug. Br J Exp Pathol 66:633–642PubMedGoogle Scholar
  10. 10.
    Haudenschild CC, Chobanian AV (1984) Blood pressure lowering diminishes age related changes in the rat aortic intima. Hypertension [Suppl I] 6:62–68Google Scholar
  11. 11.
    Haudenschild CC, Prescott MF, Chobanian AV (1980) Effects of hypertension and its reversal on aortic intima lesions of the rat. Hypertension 2:23–44Google Scholar
  12. 12.
    Lee RMKW (1985) Vascular changes at the prehypertensive phase in mesenteric arteries from spontaneously hypertensive rats. Blood Vessels 22:105–126PubMedGoogle Scholar
  13. 13.
    Lee RMKW, Forrest JB, Garfield RE, Daniel EE (1983) Ultrastructural changes of mesenteric arteries from spontaneously hypertensive rats: a morphologic study. Blood Vessels 20:72–91PubMedGoogle Scholar
  14. 14.
    Lee RMKW, Triggles CR (1986) Morphometric study of mesenteric arteries from genetically hypertensive Dahl strain rats. Blood Vessels 23:199–224PubMedGoogle Scholar
  15. 15.
    Levenson JA, Peronneau PP, Simon ACH, Safar ME (1981) Pulsed doppler: determination of diameter, blood flow velocity and volume flow of brachial artery in man. Cardiovasc Res 15:164–170PubMedCrossRefGoogle Scholar
  16. 16.
    Levy BI, Benessiano J, Poitevin P, Lubin L, Safar ME (1985) Systemic arterial compliance in normotensive and hypertensive rats. J Cardiovasc Pharmacol [Supple II] 7:22–27Google Scholar
  17. 17.
    Levy BI, Michel JB, Salzmann JL et al. (1988) Effect of chronic inhibition of converting enzyme on mechanical and structural properties of arteries in rat renovascular hypertension. Circ Res (in press)Google Scholar
  18. 18.
    Marx JL (1987) Polyphosphonositide research undated. Science 235:274–276CrossRefGoogle Scholar
  19. 19.
    Michel JB, Azizi M, Salzmann JL, Levy B, Menard J (1987) Effects of vasodilators on the structure of the aorta in normotensive aging rats. J Hypertension 5:5165–5168Google Scholar
  20. 20.
    Michel JB, Dussaule JC, Choudat L et al. (1985) Effects of antihypertensive treatment in one-clip two kidney hypertension in rats. Kidney Int 20:1011–1020Google Scholar
  21. 21.
    Michel JB, Salzmann JL, Ossondo NM, Bruneval L, Barres D, Camilleri JP (1986) Morphometrie analysis of collagen network and plasma perfused capillary bed in the myocardium of rats during evolution of cardiac hypertrophy. Basic Res Cardiol 81:142–154PubMedCrossRefGoogle Scholar
  22. 22.
    Mulvany MJ (1984) Pathophysiology of vascular smooth muscle in hypertension. J Hypertension [Suppl. Ill] 2:413–420Google Scholar
  23. 23.
    Mulvany MJ (1983) Do resistance vessel abnormalities contribute to the elevated blood pressure of spontaneously hypertensive rats? Blood Vessels 20:1–22PubMedGoogle Scholar
  24. 24.
    Mulvany MJ, Hansen PK, Palkjaer C (1978) Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrow lumen, a thickened media and an increased number of smooth muscle cell layers. Circ Res 43:854–864PubMedGoogle Scholar
  25. 25.
    Ooshima A, Fuller GC, Cardinale G, Spector S, Udenfriend S (1974) Increased collagen synthesis in blood vessels of hypertensive rats and its reversal by antihypertensive agents. Proc Natl Acad Sci USA 74:3019–3023CrossRefGoogle Scholar
  26. 26.
    Ooshima A, Fuller GC, Cardinale G, Spector S, Udenfriend S (1975) Collagen biosynthesis in blood vessels of brain and other tissues of the hypertensive rat. Science 190:898–900PubMedCrossRefGoogle Scholar
  27. 27.
    Owens GK, Rabinovitch PS, Schwartz SM (1981) Smooth muscle cell hypertrophy versus hyperplasia in hypertension. Proc Natl Acad Sci USA 78:7759–7763PubMedCrossRefGoogle Scholar
  28. 28.
    Starksen NF, Simpson PC, Bishopric N et al. (1986) Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression. Proc Natl Acad Sci USA 83:8348–8350PubMedCrossRefGoogle Scholar
  29. 29.
    Tedgui A, Chiron B, Curmi P, Juan L (1987) Effect of nicardipine and verapamil on in vitro albumin transport in rabbit thoracic aorta. Arteriosclerosis 7:80–87PubMedCrossRefGoogle Scholar
  30. 30.
    Washaw DM, Root DT, Halpern W (1980) Effects of antihypertensive drug therapy on the morphology and mechanics of resistance arteries from spontaneously hypertensive rats. Blood Vessels 17:257–270Google Scholar
  31. 31.
    Wiener J, Loud AD, Giacomelli F, Anversa P (1977) Morphometrie analysis of hypertension induced hypertrophy of rat thoracic aorta. Am J Pathol 88:619–634PubMedGoogle Scholar
  32. 32.
    Wolinski H (1970) Response of the rat aortic media to hypertension: morphological and chemical studies. Circ Res 26:507–522Google Scholar
  33. 33.
    Wolinski H (1971) Effects of hypertension and its reversal on the thoracic aorta of male and female rats. Circ Res 38: 622–637Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J.-B. Michel
  • J. L. Salzmann
  • M. Safar

There are no affiliations available

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