Structural Modifications of the Arterial Wall in Hypertension

  • J.-B. Michel
  • J. L. Salzmann
  • M. Safar


Physiological and pathological observations of the vascular system in clinical and experimental models of hypertension, normotension and cardiac insufficiency, suggest that the level of blood pressure is related directly to both primary functions of the cardiovascular system: the peripheral blood flow and filtration pressure in capillaries necessary for oxygen delivery to tissues [8,15]. For example, in spontaneously hypertensive rats, these two variables are probably in the normal range [22] which is an indication of the cardiovascular system’s ability to adopt its functional and structural parameters for survival. In human essential hypertension, cardiac output is in the normal range [3]. In experimental models, as in human beings, the homeostatic mechanisms of blood flow regulation are conserved. The adaptation of the cardiovascular system in hypertension probably is related to the minimal energy level necessary for the maintenance of a cardiovascular function compatible with survival.


Arterial Wall Collagen Content Aortic Wall Renovascular Hypertension Collagen Biosynthesis 
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© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J.-B. Michel
  • J. L. Salzmann
  • M. Safar

There are no affiliations available

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