Immunological Processes in the Vascular Wall

  • M. D. Kazatchkine
  • P. S. Seifert
  • U. E. Nydegger


Many mechanisms may be involved in the mediation of immunologically induced vascular injury. These mechanisms can be classified as humoral or cellular (Table 26.1). Humoral mechanisms involve deposition or in situ formation of immune complexes and the intravascular activation of complement. Cellular mechanisms lead to granulomatous reactions. This chapter will review the pathophysiology of vascular injury mediated by immune complexes, complement and specific and non-specific cellular effector mechanisms. Some of the functional and immunological characteristics of endothelial cells will also be considered, since the clinical features of inflammatory vascular injury depend to a large extent on the absence (as in post-capillary venules and glomerular capillaries) or presence (as in arteries) of an intact non-fenestrated continuous layer of endothelial cells.


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© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • M. D. Kazatchkine
  • P. S. Seifert
  • U. E. Nydegger

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