Progression, Topographical Aspects and Regression of Atherosclerosis

  • H. Bouissou
  • M. T. Pieraggi
  • M. Julian


The term atherosclerosis, first used by Marchand in 1904, is applied to severe arterial sclerosis associated with atheromatous lesions in varying degrees of evolution and coalescence. Macroscopically there are three classical stages: stage I, where there are fatty streaks only; stage II, where pustules and atherosclerotic plaques are separable; and stage III, with coalescent plaques, usually calcified, cartilaginous and ulcerated (see below). We will describe vessel changes in terms of these classical stages, but longitudinal studies suggest that pathogenetic consideration may require their reclassification if newer concepts are upheld (see Chap. 10). From stage II onwards, the artery outside the area covered by plaque undergoes distinct arteriosclerosis, with fibrosis and loss of elasticity of the arterial wall (see Chap. 4). Atherosclerosis and arteriosclerosis thus diminish the resistance of the wall and favour ectasia.


Foam Cell Atheromatous Plaque Fatty Streak Intercostal Artery Mural Thrombus 
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© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • H. Bouissou
  • M. T. Pieraggi
  • M. Julian

There are no affiliations available

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