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Haemolytic Uraemic Syndrome and Thrombotic Thrombocytopenic Purpura: A Review

  • Guy H. Neild
Chapter
Part of the The Bloomsbury Series in Clinical Science book series (BLOOMSBURY)

Abstract

The haemolytic uraemic syndrome (HUS) is a clinico-pathological syndrome which most commonly affects children under 2 years of age. Thrombocytopenia and a haemolytic anaemia with fragmented red cells occur together with acute renal failure and characteristic renal vascular pathology (Fong et al. 1982). It is not a single disease. The aetiology varies and in the majority, the cause remains unknown (Kaplan and Drummond 1978). Whatever the cause, the end result is extensive endothelial injury of the renal microvasculature (Fong et al. 1982; Bohle et al. 1976; Riella et al. 1976). The haematological features of HUS are believed to be a consequence of this endothelial injury.

Keywords

Fresh Freeze Plasma Thrombotic Thrombocytopenic Purpura Endothelial Injury Thrombotic Microangiopathy Haemolytic Uraemic Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1988

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  • Guy H. Neild

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