Haemolytic Uraemic Syndrome and Thrombotic Thrombocytopenic Purpura: A Review
The haemolytic uraemic syndrome (HUS) is a clinico-pathological syndrome which most commonly affects children under 2 years of age. Thrombocytopenia and a haemolytic anaemia with fragmented red cells occur together with acute renal failure and characteristic renal vascular pathology (Fong et al. 1982). It is not a single disease. The aetiology varies and in the majority, the cause remains unknown (Kaplan and Drummond 1978). Whatever the cause, the end result is extensive endothelial injury of the renal microvasculature (Fong et al. 1982; Bohle et al. 1976; Riella et al. 1976). The haematological features of HUS are believed to be a consequence of this endothelial injury.
KeywordsFresh Freeze Plasma Thrombotic Thrombocytopenic Purpura Endothelial Injury Thrombotic Microangiopathy Haemolytic Uraemic Syndrome
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