Management of Localized Adenocarcinoma of the Prostate

  • C. A. Olsson
Part of the Clinical Practice in Urology book series (PRACTICE UROLOG)


Appropriate management of the patient with localized adenocarcinoma of the prostate remains a controversial topic for various reasons. First, prostatic cancer occurs in an age group in which many other diseases affect the health of the host. Second, the biologic hazard presented by adenocarcinoma of the prostate can be exceedingly variable. This variability is dependent not simply on host factors, such as age and state of health, but also on factors indigenous to the tumor, such as degree of differentiation and metastatic potential. Finally, the majority of studies of the efficacy of one treatment modality versus another have consisted of uncontrolled analyses of patient survival comparative to historical controls alone; few randomized studies of treatment efficacy have been conducted.


Urinary Incontinence Radical Prostatectomy Prostatic Biopsy Pelvic Lymph Node Localize Prostatic Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Babayan RK, deVere White R, Austen G Jr, Krane RJ, Feldman M, Olsson CA (1980) Benefits and complications of staging pelvic lymph node dissection in prostatic adenocarcinoma. Prostate 1: 345–349PubMedCrossRefGoogle Scholar
  2. Bagshaw MA (1969) Definitive radiotherapy in carcinoma of the prostate. JAMA 210: 326–327PubMedCrossRefGoogle Scholar
  3. Bagshaw MA (1984) Radiotherapy of prostatic cancer: Stanford University experience. In: Kurth KH, Debruyne FMJ, Schroeder FH, Splinter TAM, Wagener TDJ (eds) Progress and controversies in oncological urology. Alan R. Liss, New York, pp 493–512Google Scholar
  4. Bagshaw MA, Ray GR, Cox RS (1985) Radiotherapy of prostatic carcinoma: long or short term efficacy. Urology [Suppl] 25: 17–23CrossRefGoogle Scholar
  5. Belt F, Shroeder FH (1972) Total perineal prostatectomy for carcinoma of the prostate. J Urol 107: 91–96PubMedGoogle Scholar
  6. Carlton CE Jr, Hudgins PT, Guerriero WG, Scott R Jr (1975) Radiotherapy in the management of stage C carcinoma of the prostate. Trans Am Assoc GU Surg 67: 70–74Google Scholar
  7. Cox JD, Stoffel TJ (1977) The significance of needle biopsy after irradiation for stage C adenocarcinoma of the prostate. Cancer 40: 156–160PubMedCrossRefGoogle Scholar
  8. Culp DS, Meyer JJ (1973) Radical prostatectomy in the treatment of prostatic cancer. Cancer 32: 1113–1118PubMedCrossRefGoogle Scholar
  9. Cupps RE, Utz DC, Fleming TR, Carson CC, Zincke H, Myers RP (1980) Definitive radiation therapy for prostatic carcinoma: Mayo Clinic experience. J Urol 124: 855–859PubMedGoogle Scholar
  10. Donohue RF, Pfister RR, Weigel JW, Stonington OG (1977) Pelvic lymphadenectomy in stage A prostatic cancer. Urology 9: 273–275PubMedCrossRefGoogle Scholar
  11. Eggleston JC, Walsh PC (1985) Nerve sparing radical retropubic prostatectomy. Pathologic findings in the first 100 cases. J Urol 133: abstract 511Google Scholar
  12. Freiha FS, Bagshaw MA (1984) Carcinoma of the prostate: results of post-irradiation biopsy. Prostate 5: 19–26PubMedCrossRefGoogle Scholar
  13. Golimbu M, Schinella R, Morales P, Kurusu S (1978) Stage A-2 prostatic cancer: clinical, pathological and prognostic difference from Al and B disease. J Urol 119: 618–622PubMedGoogle Scholar
  14. Hilaris BS, Whitmore WF Jr, Batata MA, Grabstald H (1974) Radiation therapy and pelvic node dissection in the management of cancer of the prostate. Am J Roentgenol 121: 832–838Google Scholar
  15. Hilaris BS, Whitmore WF Jr, Batata MA et al. (1977) Behavioral patterns of prostate adenocarcinoma following an I125 implant and pelvic lymph node dissection. Int J Radiat Oncol Biol Phys 2: 631–637PubMedCrossRefGoogle Scholar
  16. Jewett HJ, Bridge RW, Gray GF, Shelley WM (1968) The palpable nodule of prostatic cancer. Results 15 years after radical excision. JAMA 203: 403–406PubMedCrossRefGoogle Scholar
  17. Kiesling VJ, Friedman HI, McAninch JW, Nachtsheim DA, Nemeth TJ (1979) The ultrastructural changes of prostate adenocarcinoma following external beam radiation therapy. J Urol 122: 633–636PubMedGoogle Scholar
  18. Kiesling VJ, McAninch JW, Goebel JL, Agee RE (1980) External beam radiotherapy for adenocarcinoma of the prostate. A clinical follow up. J Urol 124: 851–854PubMedGoogle Scholar
  19. Kramer SA, Spahr J, Brendler CB, Glenn SF, Paulson DF (1980) Experience with Gleason’s histopathologic grading in prostate cancer. J Urol 124: 223–225PubMedGoogle Scholar
  20. Kramer SA, Cline WA Jr Farnham R, Carson CG, Cox EB, Hinshaw W, Paulson DF (1981) Prognosis of patients with stage D-l prostatic adenocarcinoma. J Urol 125: 817–819PubMedGoogle Scholar
  21. Kurth KH, Altwein JE, Hohenfellner R (1977) Follow up of irradiated carcinoma by aspiration biopsy. J Urol 117: 615–617PubMedGoogle Scholar
  22. Kurup P, Kramer TS, Lee MS, Phillips R (1984) External beam irradiation of prostate cancer. Cancer 53: 37–43PubMedCrossRefGoogle Scholar
  23. Lindner A, deKernion JB, Smith RB, Katske FA (1983) Risk of urinary incontinence following radical prostatectomy. J Urol 129: 1007–1008PubMedGoogle Scholar
  24. Mahan DE, Bruce AW, Manley PM, Fanchi L (1980) Immunohistochemical evaluation of prostatic cancer before and after radiotherapy. J Urol 124: 488–491PubMedGoogle Scholar
  25. Olsson CA, deVere White R (1982) Health risk and management of prostate cancer. In: Paulson D (ed) Cancer treatment and research (GU cancer 1), vol 6. Martinus Nijhoff, Amsterdam, pp 121–142Google Scholar
  26. Olsson CA, Tannenbaum M, Babayan R, O’Brien M, deVere White R (1982) Prediction of lymph node metastasis in adenocarcinoma of the prostate (abstr). Presented at Annual American Urological Association Annual Meeting, Kansas CityGoogle Scholar
  27. Olsson CA, Babayan R, deVere White R (1985) Surgical management of stage B or C prostatic carcinoma: radical surgery vs radiotherapy. Urology [Suppl] 25: 30–38Google Scholar
  28. Paulson DF, Uro-Oncology Research Group (1979). The impact of current staging procedures in assessing disease extent of prostatic adenocarcinoma. J Urol 121: 300–302Google Scholar
  29. Paulson DF, Lin GH, Hinshaw W, Stephani S, Uro-Oncology Research Group (1982) Radical surgery versus radiotherapy for adenocarcinoma of the prostate. J Urol 128: 502–504Google Scholar
  30. Pistenma DA, Ray GR, Bagshaw MA (1976) The role of megavoltage radiation therapy in the treatment of prostatic carcinoma. Semin Oncol 3: 115–122PubMedGoogle Scholar
  31. Ray GR, Bagshaw MA (1975) The role of radiation therapy in the definitive treatment of adenocarcinoma of the prostate. Ann Rev Med 26: 567–588PubMedCrossRefGoogle Scholar
  32. Ray GR, Bagshaw MA, Freiha FS (1984) External beam radiation salvage for residual or recurrent local tumor following radical prostatectomy. J Urol 132: 926–930PubMedGoogle Scholar
  33. Scardino PT, Delaune JM, Hoffman GS, Guerriero G, Carlton CE Jr (1982) The results and significance of prostatic biopsy after definitive radiation for carcinoma of the prostate (abstr). Presented at American Urological Association Annual Meeting, Kansas City, pp 194–195Google Scholar
  34. Vernon SE, Williams WD (1983) Pre-treatment and post-treatment evaluation of prostatic adenocarcinoma for prostatic specific antigen by immunohistochemistry. J Urol 130: 95–98PubMedGoogle Scholar
  35. Walsh PC (1980) Radical prostatectomy for the treatment of localized prostatic carcinoma. Urol Clin North Am 7: 583–591PubMedGoogle Scholar
  36. Walsh PC, Donker PJ (1982) Impotence following radical prostatectomy: insight into etiology and prevention. J Urol 128: 492–497PubMedGoogle Scholar
  37. Walsh PC, Jewett JJ (1980) Radical surgery for prostate cancer. Cancer 45: 1906–1911PubMedGoogle Scholar
  38. Whitmore WF Jr (1984) Interstitial I-125 implantation in the management of localized prostatic cancer. In: Kurth KH, Debruyne FMJ, Schroeder FH, Splinter TAM, Wagener TDJ (eds) Progress and controversies in oncological urology. Alan R. Liss, New York, pp 513–527Google Scholar
  39. Whitmore WF Jr, Hilaris B, Grabstald H (1972) Retropubic implantation of iodine125 in the treatment of prostate cancer. J Urol 108: 918–920PubMedGoogle Scholar
  40. Wilson CS, Dahl DS, Middleton RG (1977) Pelvic lymphadenectomy for the staging of apparently localized prostatic cancer. J Urol 117: 197–198PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • C. A. Olsson

There are no affiliations available

Personalised recommendations