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Hormone Receptors in Prostatic Cancer

  • B. G. Mobbs
  • J. G. Connolly
Part of the Clinical Practice in Urology book series (PRACTICE UROLOG)

Abstract

During the last decade, the clinical use of steroid hormone receptor assays has become an accepted part of the management of a number of diseases of hormone target organs. In breast cancer, and to a lesser extent in endometrial cancer, the concentrations of receptors for estrogen and progestin in the malignant tissue are regarded as prognostic factors in early disease, and as predictive factors for the value of endocrine treatment for patients with advanced disease (Knight et al. 1980; McGuire and Clark 1983). In acute lymphocytic leukemia, the cellular concentration of glucocorticoid receptors appears to be an indicator of prognosis and response to glucocorticoid therapy (Costlow et al. 1982). The assay of androgen receptor (AR) in cultured genital skin fibroblasts can assist in the diagnosis and selection of treatment of benign conditions such as androgen resistance syndromes (Bardin and Wright 1980). It is therefore somewhat disappointing that studies of the application of AR assays to the management of prostatic carcinoma, which is known to be an androgen-sensitive disease in the majority of cases, have met with very limited success. Some of the reasons for this are inherent in the nature of the disease and are discussed below. Nevertheless, the research involved in the development of these assays, together with that into related areas of the biochemistry of human and animal prostatic tissue, has added much to our knowledge of the basic mechanisms involved in the control of prostatic growth.

Keywords

Androgen Receptor Benign Prostatic Hyperplasia Human Prostate Androgen Metabolism Androgen Sensitivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • B. G. Mobbs
  • J. G. Connolly

There are no affiliations available

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