Tumor Markers in Prostatic Disease

  • A. W. Bruce
  • B. K. Choe
Part of the Clinical Practice in Urology book series (PRACTICE UROLOG)


One of the current problems in the diagnosis of prostatic cancer is that there is no procedure which can detect early localized disease curable by surgery and that truly localized cancers can only be detected by rectal examination in 10%–20% of patients. Another problem is the variability of the natural history of the disease. Clinically, some tumors remain localized for long periods, producing few, if any symptoms or signs, and others disseminate widely before symptoms are manifested. Due to this, numerous grading systems, as well as highly sophisticated cytometric systems, have been introduced to correlate the morphologic parameters of the cancer cells with their biologic characteristics, such as growth rate and metastatic potential. In addition, various biochemical or immunochemical markers have been researched in the past, and some of the molecular markers of prostatic cancer have found a place in the clinical laboratory (Benson and Coffey 1983; Whitmore 1984).


Prostatic Cancer Acid Phosphatase Benign Prostatic Hyperplasia Prostatic Cancer Patient Adenoid Cystic Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • A. W. Bruce
  • B. K. Choe

There are no affiliations available

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