Abstract
To provide a much needed estimate of growth and malignant potential of tumors, Broders (1925) proposed that tumors be divided into four grades:
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Grade I: Three-fourths of the tumor is differentiated, one-fourth is undifferentiated.
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Grade II: The proportion of differentiated and undifferentiated components is about equal.
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Grade III: Three-fourths of the tumor is undifferentiated, one-fourth of the tumor is differentiated.
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Grade IV: The tumor shows no tendency to cell differentiation.
The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.
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Mostofi, F.K. (1987). Grading of Prostatic Carcinomas—Current Status. In: Bruce, A.W., Trachtenberg, J. (eds) Adenocarcinoma of the Prostate. Clinical Practice in Urology. Springer, London. https://doi.org/10.1007/978-1-4471-1398-0_2
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