Chemotherapy of Prostatic Cancer

  • R. P. Huben
  • G. P. Murphy
Part of the Clinical Practice in Urology book series (PRACTICE UROLOG)

Abstract

Optimal management of patients with hormone-refractory prostatic cancer remains problematic. While there is some acceptance of the results of numerous clinical studies which have reported that chemotherapy is superior to further hormonal approaches or other supportive measures as a treatment option for hormone-refractory prostatic cancer, there persists a “general pessimism” about the use of chemotherapy in this patient population (Scott et al. 1976; Murphy et al. 1977; Logathetis et al. 1983; Torti 1983). This pessimism may be caused in part by the variability in clinical course of metastatic prostatic cancer and the problems in determining response to therapy in a systemic stage of disease which is particularly difficult to quantify. Since there is reason to question the overall impact of hormonal therapy in advanced prostatic cancer, it is not surprising that the impact of chemotherapy, which may cause a far less dramatic response, is all the more controversial.

Keywords

Adenocarcinoma Doxorubicin Methotrexate Cyclophosphamide Vincristine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • R. P. Huben
  • G. P. Murphy

There are no affiliations available

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