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Hormonal Therapy in Metastatic Prostatic Cancer

  • J. Trachtenberg
Part of the Clinical Practice in Urology book series (PRACTICE UROLOG)

Abstract

The concept of hormonal therapy for prostatic cancer was introduced in 1941 by Huggins and Hodges with the prospect of curing even the most advanced of cases. They reasoned that since normal prostatic epithelium is androgen dependent, prostatic cancer should be similarly dependent. They and others then demonstrated that human prostatic cancer could be made to regress by the administration of pharmacologic doses of estrogens or by castration (Huggins et al. 1941; Spirnak and Resnick 1983). However, after a decade of enthusiastic and optimistic use of these forms of androgen ablation in all stages of prostatic cancer, it became apparent that hormonal therapy was not to be the panacea initially envisaged. Clinical studies conducted from 1942 to 1983 failed to define clearly the indications for this treatment except to demonstrate that hormonal therapy could not cure prostatic cancer. Studies by Vest and Frazier (1946), Nesbit and Plumb (1946), and Nesbit and Baum (1950) all suggested that hormonal therapy prolonged survival of patients with metastatic disease. However, the Veterans Administration Cooperative Urological Research Group (VACURG) (1967) failed to demonstrate any survival benefit of early hormonal therapy in advanced disease. Lepor et al. (1982) compared the survival of patients with metastatic disease treated immediately prior to the introduction of hormonal therapy with that in patients treated immediately after.

Keywords

Prostatic Cancer Hormonal Therapy Advanced Prostatic Cancer Metastatic Prostatic Cancer Luteinizing Hormone Release Hormone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Anderson KM, Liao S (1968) Selective retention of dihydrotestosterone by prostatic nuclei. Nature 219: 277–279PubMedCrossRefGoogle Scholar
  2. Baxter JD, Funder JW (1979) Hormone receptors. N Engl J Med 301: 1149–1161PubMedCrossRefGoogle Scholar
  3. Beland J, Elhilali M (1986) A prospective randomized trial of total androgen ablation in metastatic prostatic cancer (abstr). Proceedings of the Second International Conference on Prostate Cancer. ParisGoogle Scholar
  4. Blackard CE, Doe RP, Mellinger GT et al. (1970) Incidence of cardiovascular disease and death in patients receiving diethylstilbestrol for carcinoma of the prostate. Cancer 26: 249–256PubMedCrossRefGoogle Scholar
  5. Brendler H (1973) Adrenalectomy and hypophysectomy for prostatic cancer. Urology 2: 99–102PubMedCrossRefGoogle Scholar
  6. Burton S, Trachtenberg J (1986) Effectiveness of antiandrogens in the rat. J Urol 136 (4): 932–935PubMedGoogle Scholar
  7. Ekman P, Greene GL, Jensen EV, Walsh PC (1983) Estrogen receptors in human prostate: evidence for multiple binding sites. J Clin Endocrinol Metab 57: 166–176PubMedCrossRefGoogle Scholar
  8. Geller J, Albert JD (1983) Comparison of various hormonal therapies for prostatic cancer. Semin Oncol 10(4) [Suppl 4] 34–41PubMedGoogle Scholar
  9. Glashan RW, Robinson MRG (1981) Cardiovascular complications in the treatment of prostatic cancer. Br J Urol 53: 624–647PubMedCrossRefGoogle Scholar
  10. Huggins C, Hodges CV (1941) Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res 1: 293–297Google Scholar
  11. Huggins C, Stevens RE, Hodges CV (1941) Studies on prostatic cancer: II. The effects of castration on advanced carcinoma of the prostate gland. Arch Surg 43: 209–223Google Scholar
  12. Isaacs JT, Heston WDW, Weissman RM, Coffey DS (1978) Animal models of the hormone-sensitive and insensitive prostatic adenocarcinoma, Dunning R-3327-H, R-3327-HI, and R3327-AT. Cancer Res 38: 4353–4359PubMedGoogle Scholar
  13. Labrie F, Dupont A, Belanger A et al. (1982) New hormonal therapy in prostatic cancer: combined treatment with an LHRH agonist and an antiandrogen. Clin Invest Med 5: 267–275PubMedGoogle Scholar
  14. Labrie F, Dupont A, Belanger A et al. (1985) Antiandrogens and LHRH agonists in the treatment of prostatic cancer. Medicine/Science 1: 435Google Scholar
  15. Lepor H, Ross A, Walsh PC (1982) The influence of hormonal therapy on survival of men with advanced prostatic cancer. J Urol 128: 335–340PubMedGoogle Scholar
  16. Matsuo H, Baba Y, Nair RMG, Arimura A, Schally AV (1971) Structure of the porcine Lh and FSH releasing hormone 1. The proposed amino acid sequence. Biochem Biophys Res Comm 43: 1334–1339PubMedCrossRefGoogle Scholar
  17. Nesbit RM, Baum WC (1950) Endocrine control of prostatic carcinoma: clinical and statistical survey of 1818 cases. JAMA 143: 1317–1320Google Scholar
  18. Nesbit RM, Plumb RT (1946) Prostatic carcinoma: a follow-up of 795 patients treated prior to the endocrine era and a comparison of survival rates between these and patients treated by endocrine therapy. Surgery 20: 263–272PubMedGoogle Scholar
  19. Schroder FH, Klijn JG, de Jong FH (1986) Metastatic cancer of the prostate managed by Buserelin acetate versus Buserelin acetate plus cyproterone acetate. Proceedings of the Annual Meeting of the American Urological Association, New York. J Urol 135: 202AGoogle Scholar
  20. Scott WW, Menon M, Walsh PC (1980) Hormonal therapy of prostatic cancer. Cancer 45: 1929–1936PubMedGoogle Scholar
  21. Shearer RJ, Hendry WF, Sommerville IF et al. (1973) Plasma testosterone: an accurate monitor of hormone treatment in prostatic cancer. Br J Urol 45: 668–677PubMedCrossRefGoogle Scholar
  22. Sogani PC, Vagawal MR, Whitmore WF Jr (1983) Experience with flutamide in patients with advanced prostatic cancer without prior endocrine therapy. Cancer 54: 744–750CrossRefGoogle Scholar
  23. Spirnak JP, Resnick MI (1983) Carcinoma of the prostate: early endocrine therapy is best. Semin Urol 1: 269–279PubMedGoogle Scholar
  24. The Leuprolide Study Group (1984) Leuprolide vrs DES in the initial therapy of advanced prostatic cancer: a randomized prospective trial. N Engl J Med 311: 1281–1286CrossRefGoogle Scholar
  25. Tolis G, Menta A, Kinch R, Comaru-Schally AM, Schally AV (1980) Suppression of sex steroids by an LH-Rh analogue in man. Clin Res 28: 676AGoogle Scholar
  26. Trachtenberg J, Pont A (1984) Ketoconazole in the treatment of metastatic prostatic cancer. Lancet 11: 433–435CrossRefGoogle Scholar
  27. Trachtenberg J, Zadra J (1986) Total androgen ablation therapy in the treatment of advanced prostatic cancer. Proceedings of the Annual Meeting of the American Urological Association, New York. J Urol 135: 201AGoogle Scholar
  28. Vest SA, Frazier TH (1946) Survival following castration for prostatic cancer. J Urol 56:97–111PubMedGoogle Scholar
  29. Veterans Administration Cooperative Urological Research Group (1967) Treatment and survival of patients with cancer of the prostate. Surg Gynecol Obstet 124: 1011–1017Google Scholar
  30. Walsh PC (1975) Physiologic basis for hormonal therapy in carcinoma of the prostate. Urol Clin North Am 2: 125–140PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • J. Trachtenberg

There are no affiliations available

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