Advertisement

The Place for Radiotherapy in Endometrial Cancer

  • C. A. Joslin

Abstract

The incidence of cancer of the endometrium is increasing and in the United Kingdom almost equals that of cervical cancer. Clinically, it most commonly presents as stage I disease, being locally confined to the endometrial and myo-metrial tissues. However, depending upon the grade of tumour and depth of myometrial invasion the chance of regional spread to the pelvic lymph nodes can be as high as 50% [1]. Management for stage I endometrial cancer is therefore not only concerned with the eradication of disease in the primary organ, but also with determining the likelihood of pelvic node involvement and providing appropriate treatment.

Keywords

Endometrial Cancer Endometrial Carcinoma Myometrial Invasion Pelvic Recurrence Corpus Uterus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Javert CT (1958) Prognosis of endometrial cancer. Obstet Gynecol 30:147–169Google Scholar
  2. 2.
    Regaud C (1922) Influence de la durée d’irradiation sur les effets déterminés dans le testicule par le radium. CR Soc Biol (Paris) 86:787–790Google Scholar
  3. 3.
    Heyman J (1947) Improvement of results in the treatment of uterine cancer JAMA 135:412–416Google Scholar
  4. 4.
    Kottmeier HL (1959) Carcinoma of the corpus uteri; diagnosis and therapy. Am J Obstet Gynecol 78:1127–1140PubMedGoogle Scholar
  5. 5.
    Jones HW (1975) Treatment of adenocarcinoma of the endometrium. Obstet Gynecol Surv 30:147–169PubMedCrossRefGoogle Scholar
  6. 6.
    Strickland P (1965) Carcinoma corporis uteri: A radical intracavitary treatment. Clin Radiol 16:112–118PubMedCrossRefGoogle Scholar
  7. 7.
    Simon N, Silverstone SM (1976) Afterloading with miniaturized 137 Cs sources in the treatment of cancer of the uterus. Int J Radiat Oncol Biol Phys 1:1017–1021PubMedCrossRefGoogle Scholar
  8. 8.
    Randall JH, Goddard WB (1956) A study of 531 cases of endometrial carcinoma. Surg Gynecol Obstet 103:221–226PubMedGoogle Scholar
  9. 9.
    Lampe I (1963) Endometrial carcinoma Am J Roentgenol 90:1011–1015Google Scholar
  10. 10.
    Delclos L, Fletcher GH (1969) Malignant tumours of the endometrium: Evaluation of some aspects of radiotherapy. M.D. Anderson Hospital. In: Cancer of the uterus and ovary 11th Clinical conference on cancer. M.D. Anderson Hospital and Tumor Institute, Houston, 1966. Year Book Medical Publishers, Chicago, pp 62–72Google Scholar
  11. 11.
    Lewis BV, Stallworthy JA, Cowdell R (1970) Adenocarcinoma of the body of the uterus. J. Obstet Gynaecol Br Commonw 77:343–348PubMedCrossRefGoogle Scholar
  12. 12.
    Javert CT (1952) The spread of a benign and malignant endometrium in the lymphatic system with a note on co-existing vascular involvement. Am J Obstet Gynecol 64:780–806PubMedGoogle Scholar
  13. 13.
    Lees DH (1969) An evaluation of treatment in carcinoma of the body of the uterus. J Obstet Gynaecol Br Commonw 76:615–623PubMedCrossRefGoogle Scholar
  14. 14.
    Shah CA, Green TH (1972) Evaluation of current management of endometrial carcinoma. Obstet Gynecol 39:500–509PubMedGoogle Scholar
  15. 15.
    Lewis BV (1971) Nodal spread in relation to penetration and differentiation. Proc R Soc Med 64:406–407PubMedGoogle Scholar
  16. 16.
    Di Saia PJ, Creasman WT (1981) Clinical gynecologic oncology. CV Mosby, St. Louis, p 144Google Scholar
  17. 17.
    Salazar OM, Feldstein ML, DePapp EW, Bonfiglio TA, Keller BE, Rubin P, Rudolph JM (1978) Management of clinical stage I endometrial carcinoma. Cancer 41:1016–1026PubMedCrossRefGoogle Scholar
  18. 18.
    Graham J (1971) The value of pre-operative or post-operative treatment by radium for carcinoma of the uterine body. Surg Gynecol Obstet 132:855–860PubMedGoogle Scholar
  19. 19.
    Piver MS (1980) Stage I endometrial carcinoma: The role of adjunctive radiation therapy. Int J Radiat Oncol Biol Phys 6:367–368PubMedCrossRefGoogle Scholar
  20. 20.
    Kuipers TJ (1981) Personal communication to the European Curietherapy GroupGoogle Scholar
  21. 21.
    Boronow RC (1969) Carcinoma of the corpus: Treatment at M.D. Anderson Hospital, In: Cancer of the uterus and ovary. 11th clinical conference on cancer. M.D. Anderson Hospital and Tumor Institute, Houston, 1966. Year Book Medical Publishers, Chicago, pp 62–72Google Scholar
  22. 22.
    Dally VM (1978) The optimization of radiotherapy in endometrial cancer. In: Brush MG, King RJB, Taylor RW (eds) Endometrial cancer. Ballière Tindall, London, pp 163–178Google Scholar
  23. 23.
    Dobbie BMW (1953) Vaginal recurrences in carcinoma of the body of the uterus and their prevention by radiotherapy. J Obstet Gynaecol Br Commonw 60:702–705CrossRefGoogle Scholar
  24. 24.
    Ritcher N, Lucas WE, Yon JL, Sanford GD (1981) Preoperative whole pelvic external irradiation — stage I endometrial cancer. Cancer 48:58–62PubMedCrossRefGoogle Scholar
  25. 25.
    Gagnon JD, Moss WT, Gabourel LS, Stevens KR (1979) External irradiation in the management of stage II endometrial carcinoma. Cancer 44:1247–1251PubMedCrossRefGoogle Scholar
  26. 26.
    Onsrud M, Kolstad P, Normann T (1976) Postoperative external pelvic irradiation in carcinoma of the corpus stage I: A controlled clinical trial. Gynecol Oncol 4:222–231PubMedCrossRefGoogle Scholar
  27. 27.
    Creasman WT, Boronow RC, Morrow CP, Disai PJ, Blessing J (1976) Adenocarcinoma of the endometrium: Its metastatic lymph node potential. Gynecol Oncol 4:239PubMedCrossRefGoogle Scholar
  28. 28.
    Joslin CA, Vaishampayan GV, Mallik A (1977) The treatment of early cancer of the corpus uteri. Br J Radiol 50:38–45PubMedCrossRefGoogle Scholar
  29. 29.
    Purcell JL, Underwood PB (1971) Adenocarcinoma of the endometrium: A ten-year experience at the Medical University of South Carolina. South Med J 64:961–966PubMedCrossRefGoogle Scholar
  30. 30.
    Dobbie BMW, Taylor CW, Waterhouse JAH (1965) A study of carcinoma of the endometrium. J Obstet Gynaecol Br Commonw 72:659–673PubMedCrossRefGoogle Scholar
  31. 31.
    Rutledge FN, Tan SK, Fletcher GH (1958) Vaginal metastasis from adenocarcinoma of the corpus uteri. Am J Obstet Gynecol 75:164–174Google Scholar
  32. 32.
    Beiler DD, Schmutz DA, O’Rourke TL (1972) Carcinoma of the endometrium: Radiation and surgery versus surgery alone. Radiology 102:159–164PubMedGoogle Scholar
  33. 33.
    Liu W. Meigs JV (1955) Radical hysterectomy and pelvic lymphadenectomy: A review of 473 cases including 244 for primary invasive carcinoma of the cervix. Am J Obstet Gynecol 69:1–32PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • C. A. Joslin

There are no affiliations available

Personalised recommendations