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Miscellaneous

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Ultrastructure of the Small Intestinal Mucosa

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Abstract

The malignancies most likely to affect the jejunal mucosa are the lymphomas or lymphosarcomas or more rarely the adenocarcinomas. They are usually diagnosed radiologically or at laparotomy and only very rarely by jejunal mucosal biopsy. Most malignancies of the jejunum in Western countries are circumscribed masses located in the middle or lower jejunum, and therefore not in the site normally biopsied by peroral technique. This contrasts with the so-called ‘Mediterranean lymphomas’ or IPSID (immunoproliferative small intestinal diseases) which are often diffuse, usually affect the duodenum and Upper jejunum (but may also extend into the lower parts of the small intestine), and are therefore within reach of the endoscope or peroral jejunal biopsy technique. Again, limited information is available on the ultrastructural appearances of both types of lymphomas [11,19,20,21,22,23,24,38].

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References

  1. Baker RWR, Thompson RHS, Zilkha KJ (1964) Serum fatty acids in multiple selerosis. J Neurol Neurosurg Psychiatry 27: 408–414

    Article  PubMed  CAS  Google Scholar 

  2. Ballazs M (1979) Repeated light- and electron-microscopic studies of the small-bowel mucosa in Whipple’s disease. Exp Pathol (Jena) 17: 249–263

    Google Scholar 

  3. Barbieri D, DeBrito T, Hoshino S et al. (1970) Giardiasis in childhood. Absorption tests and biochemistry, histochemistry, light and electron microscopy of jejunal mucosa. Arch Dis Child 454: 466–472

    Article  Google Scholar 

  4. Bateson MC, Hopwood D, McGillivray JB (1979) Jejunal morphology in multiple selerosis. Lancet i: 1108–1110

    Google Scholar 

  5. Baudon JJ, Fontaine JL, Larregue M, Feldmann G, Laplane R (1978) Acrodermatitis enteropathica. Anatomo-clinical study of 2 familial cases treated with zinc sulfate. Arch Fr Pediatr 35: 63–73

    PubMed  CAS  Google Scholar 

  6. Brandborg LL, Tankersley CB, Gottlieb S, Barancik M, Sartor VE (1967) Histologieal demonstration of mucosal invasion by giardia lamblia in man. Gastroenterology 52: 143–150

    PubMed  CAS  Google Scholar 

  7. Brooks SE, Audretsch J, Miller CG, Sparke B (1970) Electron microscopy of giardia lamblia in human jejunal biopsies. J Med Microbiol 3: 196–199

    Article  PubMed  CAS  Google Scholar 

  8. Cook MG, Turnbull GJ (1975) A hypothesis for the pathogenesis of Crohn’s disease based on an ultrastructural study. Virchows Arch (Pathol Anat) 365: 327–336

    Article  CAS  Google Scholar 

  9. Djaldetti M (1976) Crystalline inclusions in multiple myeloma. Case histories in human medicine, No 10. Philips, Holland

    Google Scholar 

  10. Dobbins WO III, Kawanishi H (1981) Bacillary eharacteristics in Whipple’s disease: an electron microscopic study. Gastroenterology 80: 1468–1475

    PubMed  Google Scholar 

  11. Doe WF, Henry K, Hobbs JR et al. (1972) Five cases of alpha chain disease. Gut 13: 947–957

    Article  PubMed  CAS  Google Scholar 

  12. Dvorak AM (1980) Ultrastructural evidenee for release of major basic protein-containing crystalline cores of eosinophil granules in vivo: cytotoxic potential in Crohn’s disease. J Immunol 125: 460–462

    PubMed  CAS  Google Scholar 

  13. Dvorak AM, Dickersin GR (1979) Crohn’s disease: electron microscopic studies. Pathol Annu 14: 259–306

    Google Scholar 

  14. Dvorak AM, Dickersin GR (1980) Crohn’s disease: transmission electron microscopic studies. I. Barrier funetion. Possible changes related to alterations of cell coat, mueous coat, epithelial cells, and Paneth cells. Hum Pathol 11: 561–571

    Google Scholar 

  15. Dybker R, Kok N (1965) Bacteria in Whipple’s disease. 3. Studies in two patients of antibodies in serum and cutaneous hypersensitivity against some bacterial antigens. Acta Pathol Microbiol Scand 64: 373–380

    Google Scholar 

  16. Gitnick GL, Rosen VJ (1976) Electron microscopic studies of viral agents in Crohn’s disease. Lancet ii: 217–219

    Google Scholar 

  17. Greenberger NJ, DeLor CJ, Fisher J et al. (1971) Whipple’s disease. Characterization of anaerobic corynebacteria and demonstration of bacilli in vascular endothelium. Am J Dig Dis 16: 1127–1136

    Article  PubMed  CAS  Google Scholar 

  18. Heilmann K, Rossner JA, Braun O (1973) Light and electron microscopy studies on biopsies of the small intestine in acrodermatitis enteropathica. Verh Dtsch Ges Pathol 57: 450

    PubMed  CAS  Google Scholar 

  19. Henry K (1975) Electron microscopy in the non-Hodgkin’s lymphomata. Br J Cancer 31 [Suppl II]: 73–93

    Google Scholar 

  20. Henry K, Farrer-Brown G (1977) Primary lymphomas of the gastrointestinal tract. I. Plasma cell tumours. Histopathol 1: 53–76

    Article  CAS  Google Scholar 

  21. Horowitz A, Shiner M (1981) The recognition of premalignant change in jejunal mucosal biopsies of patients with malabsorption. J Submicrosc Cytol 13: 423–443

    PubMed  CAS  Google Scholar 

  22. Isaacson P, Wright DH (1978) Intestinal lymphoma associated with malabsorption. Lancet i: 67–70

    Google Scholar 

  23. Isaacson P, Wright DH (1978) Malignant histiocytes of the intestine. Its relationship to malabsorption and ulcerative jejunitis. Hum Pathol 9: 661–667

    Google Scholar 

  24. Isaacson P, Wright DH (1980) Malabsorption and intestinal lymphomas. In: Wright R (ed) Recent advances in gastrointestinal pathology. Saunders, London-Philadelphia-Toronto, pp 193–212

    Google Scholar 

  25. Kingston D, Shiner M, Lange LS, Mertin J, Meade C (1977) Measles antigen in jejunal mucosa in multiple selerosis. Lancet i: 1313

    Google Scholar 

  26. Lamberty J, Varela PY, Font RG, Jarvis BW, Coover J (1974) Whipple’s disease: light and electron microscopy study. Arch Pathol 98: 325–330

    PubMed  CAS  Google Scholar 

  27. Lange LS, Shiner M (1976) Small bowel abnormalities in multiple sclerosis. Lancet ii: 1319–1322

    Google Scholar 

  28. Mertin J, Hughes D, Stewart-Wynne E (1974) P.H.A. transformation in multiple sclerosis. Inhibition by linoleic acid. Lancet i: 1005–1006

    Google Scholar 

  29. Morecki R, Parker JG (1967) Ultrastructural studies of the human giardia lamblia and subjacent jejunal mucosa in a subject with steatorrhoea. Gastroenterology 52: 151–164

    PubMed  CAS  Google Scholar 

  30. Morningstar WA (1975) Whipple’s disease. An example of the value of the electron microscope in diagnosis, follow-up, and correlation of a pathologic process. Hum Pathol 6: 443–454

    Article  PubMed  CAS  Google Scholar 

  31. Polanco I, Nistal M, Guerrero J, Väzquez C (1976) Acrodermatitis enteropathica, zinc, and ultrastructural lesions in Paneth cells. Lancet i: 430

    Google Scholar 

  32. Prasad I, Broome JD, Pertschuk LP, Gupta J, Cook AW (1977) Recovery of paramyxovirus from the jejunum of patients with multiple sclerosis. Lancet i: 1117–1119

    Google Scholar 

  33. Puppala AR, Singh S, Munaswamy M (1978) Whipple’s disease. Endoscopic documentation, light and electron microscopic features in an 80-year-old man. Am J Gastroenterol 70: 407–411

    PubMed  CAS  Google Scholar 

  34. Rayhanzadeh S, Dantzig P (1974) Acrodermatitis enteropathica, with pathologic findings in jejunum and skin. Pediatrics 54: 77–80

    PubMed  CAS  Google Scholar 

  35. Riemann JF (1977) Further electron microscopic evidence of virus-like particles in Crohn’s disease. Acta Hepatogastroenterol (Stuttg) 24: 116–118

    CAS  Google Scholar 

  36. Roberts DM, Themann H, Knust FJ, Preston FE, Donaldson JR (1970) An electron- microscope study of bacteria in two cases of Whipple’s disease. J Pathol 100: 249–255

    Article  PubMed  CAS  Google Scholar 

  37. Sanel FT, Lepore MJ (1968) Granular and crystalline deposits in perinuclear and ergastoplasmic cisternae of human lamina propria cells. Exp Mol Pathol 9: 110–124

    Article  PubMed  CAS  Google Scholar 

  38. Scotto J, Strahn H, Caroli J (1970) Ultrastructural study of two cases of alpha-chain disease. Gut 11: 782–788

    Article  PubMed  CAS  Google Scholar 

  39. Shiner M (1979) Malignant potential of intestinal plasma cells in alpha-chain disease. Lancet i: 156–157

    Google Scholar 

  40. Stemmermann GN, Hayashi T, Glober GA (1980) Cryptosporidiosis. Report of a fatal case complicated by disseminated toxoplasmosis. Am J Med 69: 637–642

    Article  PubMed  CAS  Google Scholar 

  41. Tandon BW, Puri BK, Ghandi PC, Tewari SG (1974) Mucosal surface injury of jejunal mucosa in patients with giardiasis: an electron microscopic study. Indian J Med Res 62: 1838–1842

    PubMed  CAS  Google Scholar 

  42. Trier JS, Moxey PC, Schimmel EM, Robles E (1974) Chronic intestinal coccidiosis in man: intestinal morphology and response to treatment. Gastroenterology 66: 923–935

    PubMed  CAS  Google Scholar 

  43. Weinstein L, Edelstein SM, Madara JL et al. (1981) Intestinal cryptosporidiosis complicated by disseminated cytomegalovirus infection. Gastroenterology 81: 584–591

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Clinical Research Centre, Harrow, Middlesex, UK

    Margot Shiner FRCP, FRCPath, DCH (Member, Scientific Staff, Medical Research Council, Hon. Consultant in Gastroenterology)

  2. Central Middlesex Hospital, Park Royal, London, UK

    Margot Shiner FRCP, FRCPath, DCH (Member, Scientific Staff, Medical Research Council, Hon. Consultant in Gastroenterology)

  3. Northwick Park Hospital, Harrow, Middlesex, UK

    Margot Shiner FRCP, FRCPath, DCH (Member, Scientific Staff, Medical Research Council, Hon. Consultant in Gastroenterology)

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  1. Margot Shiner FRCP, FRCPath, DCH
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© 1983 Springer-Verlag Berlin Heidelberg

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Shiner, M. (1983). Miscellaneous. In: Ultrastructure of the Small Intestinal Mucosa. Springer, London. https://doi.org/10.1007/978-1-4471-1338-6_6

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  • DOI: https://doi.org/10.1007/978-1-4471-1338-6_6

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1340-9

  • Online ISBN: 978-1-4471-1338-6

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