Abstract
This Syndrome, seen in children during the first and second years of life, may be defined as an intolerance to and malabsorption of a protein component in cow’s milk, resulting in diarrhoea, weight loss and generally failure to thrive. Although it has been shown that beta-lactoglobulin is the most ‘allergenic’ [1,14] protein in cow’s milk, it is not the only protein to which intolerance may be developed [3]. The Syndrome is clinically recognised when withdrawal of cow’s milk causes improvement and re-introduction results in deterioration [3,15].
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References
Freier S, Kletter B, Gery I, Lebenthal E, Geifman M (1969) Intolerance of milk protein. J Pediatr 75: 623–631
Gerrard JW, MacKenzie JWA, Goluboff N, Garson JZ, Maningas CS (1973) Cow’s milk allergy: prevalenee and manifestations in an unselected series of newborns. Acta Paediatr Scand [Suppl] 234: 1–21
Goldman AS, Anderson DW, Seilers W et al. (1963) Milk allergy. I. Oral challenge with milk and isolated milk proteins in allergic children. Pediatrics 32: 425–443
Iancu T, Elian E (1976) The intestinal microvillus. Ultrastructural variability in coeliac disease and cow’s milk intolerance. Acta Paediatr Scand 65: 65–73
Kuitunen P, Rapola, J, Savilahti E, Visakorpi JK (1973) Response of the jejunal mucosa to cow’s milk in the malabsorption Syndrome with cow’s milk intolerance. Acta Paediatr Scand 62: 585–595
Kuitunen P, Visakorpi JK, Savilahti E, Pelkonen P (1975) Malabsorption Syndrome with cow’s milk intolerance: clinical Undings and course in the light of 54 cases. Arch Dis Child 50: 351–356
Matthews TS, Soothill JF (1970) Complement activation after milk feeding in children with cow’s milk allergy. Lancet ii: 893–895
Patterson S, Roebuck P, Platts-Mills TAE et al. (1981) IgE plasma cells in human jejunum demonstrated by immune electron microscopy. Clin Exp Immunol 46: 301–304
Pearson JR Kingston D, Shiner M (1981) Specific antibody production to milk proteins in the jejunal mucosa of children with cow’s milk protein intolerance. Gut 22: A421
Savilahti E (1973) Immunochemical study of the malabsorption Syndrome with cow’s milk intolerance. Gut 14: 491–501
Shiner M. Ballard J, Brook CGD, Herman S (1975) Intestinal biopsy in the diagnosis of cow’s milk protein intolerance without acute symptoms. Lancet ii: 1060–1063
Shiner M, Ballard J, Smith M (1975) The small intestinal mucosa in cow’s milk allergy. Lancet i: 136–140
Visakorpi JK (1979) Milk allergy and the gastrointestinal tract in children. In: Asquith P (ed) Immunology of the gastrointestinal tract. Churchill Livingstone, Edinburgh, London, New York, pp 183–194
Visakorpi JK, Immonen P (1967) Intolerance to cow’s milk and wheat gluten in the primary malabsorption Syndrome in infancy. Acta Paediatr Scand 56: 49–56
Walker-Smith J (1979) Cow’s milk protein intolerance. In: Diseases of the small intestine in childhood. Pitman Medical, London, pp 143–158
Walker-Smith J (1979) Cow’s milk protein intolerance: In: Diseases of the small intestine in childhood, 2nd edn. Pitman Medical, London, p 145
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© 1983 Springer-Verlag Berlin Heidelberg
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Shiner, M. (1983). Cow’s Milk Protein Intolerance (CMPI). In: Ultrastructure of the Small Intestinal Mucosa. Springer, London. https://doi.org/10.1007/978-1-4471-1338-6_4
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DOI: https://doi.org/10.1007/978-1-4471-1338-6_4
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