Functional Zonation of the Adrenal Cortex
The concept of functional zonation of the adrenal cortex, and the mechanisms of intraglandular regulation of steroidogenesis that underlie it, are important both for an understanding of the normal gland, and to explain certain hitherto puzzling or paradoxical aspects of its pathology. We believe that functional zonation stems, in part at least, from different steroid concentration gradients across the cortex, and have proposed that it is the responses of the individual cortical cells to this aspect of their local microenvironment that creates and sustains some zonal differences in their steroidogenic functions (Hornsby and O’Hare 1977; O’Hare et al. 1978; Neville and O’Hare 1979).
KeywordsMigration HPLC Cortisol Angiotensin Glucocorticoid
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