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Sclerosing Bone Dysplasias pp 43–54Cite as

Metaphyseal Dysplasia (Pyle Disease)

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Abstract

Under the title ‘A case of unusual bone development,’ a Connecticut orthopaedic surgeon, Edwin Pyle (1931), reported a healthy 5-year-old boy in whom the mild clinical feature of knock-knees contrasted with gross under-modelling of the metaphyses of the tubular bones. Bakwin and Krida (1937) restudied this patient, together with his affected younger sister, and termed the condition ‘familial metaphyseal dysplasia.’ Subsequently, Hermel et al. (1953), Komins (1954), and Feld et al. (1954) employed the same designation in descriptions of pairs of affected siblings who presented in adulthood.

Keywords

  • Affected Sibling
  • Tubular Bone
  • Semantic Confusion
  • Metaphyseal Dysplasia
  • Sclerosing Bone Dysplasia

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Authors and Affiliations

  1. Department of Human Genetics, Medical School and Groote Schuur Hospital, University of Cape Town, South Africa

    Professor Peter Beighton M.D., Ph.D., F.R.C.P., D.C.H.

  2. Department of Radiology, Groote Schuur and Red Cross Children’s Hospital, University of Cape Town, South Africa

    Professor Bryan J. Cremin F.R.A.C.R., F.R.C.R.

Authors
  1. Professor Peter Beighton M.D., Ph.D., F.R.C.P., D.C.H.
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  2. Professor Bryan J. Cremin F.R.A.C.R., F.R.C.R.
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© 1980 Springer-Verlag Berlin Heidelberg

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Beighton, P., Cremin, B.J. (1980). Metaphyseal Dysplasia (Pyle Disease). In: Sclerosing Bone Dysplasias. Springer, London. https://doi.org/10.1007/978-1-4471-1292-1_7

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  • DOI: https://doi.org/10.1007/978-1-4471-1292-1_7

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1294-5

  • Online ISBN: 978-1-4471-1292-1

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