Magnetic Resonance Imaging of Patients with Isolated Idiopathic Optic Neuritis, Brainstem Syndromes and Myelopathy
In about 90% of patients with multiple sclerosis (MS), the initial clinical event is an acute and usually reversible monosymptomatic episode of central nervous system dysfunction (Matthews 1990). In most instances, the symptoms and signs indicate the presence of a lesion in either the spinal cord (about 50% of cases), optic nerves (25%) or brainstem (15%). However, not all patients presenting with such syndromes go on to develop further neurologic events disseminated in time and space that allow the diagnosis of MS (Poser et al. 1983). Indeed, such syndromes can sometimes be a manifestation of the monophasic demyelinating disorder, acute disseminated encephalomyelitis (ADEM), or they may be due to a focal structural lesion for which there is an effective treatment.
KeywordsMultiple Sclerosis Expand Disability Status Scale Optic Neuritis Lesion Load Definite Multiple Sclerosis
Unable to display preview. Download preview PDF.
- Barkhof F, Filippi M, Tas MW et al. (1994) Towards specific MR imaging criteria for early MS. Proceedings of the European Committee for Treatment and Research in Multiple Sclerosis, 10th Congress. University Studio Press, Athens. p 9Google Scholar
- Davie CA, Barker GJ, Webb S et al. (1994) Proton magnetic resonance spectroscopy (MRS) study of cerebellar dysfunction in multiple sclerosis. J Neurol 341(Suppl l):S151Google Scholar
- Matthews WB (1991) Clinical aspects. In: Matthews WB (ed) McAlpine’s multiple sclerosis, 2nd edn. Churchill Livingstone, London, pp 43–300Google Scholar
- Miller DH, McDonald WI, Johnson G et al. (1987b) Gadolinium-DTPA enhanced MRI of the brain and orbits in patients with clinically isolated optic neuritis. Proceedings of the Society of Magnetic Resonance in Medicine, 6th annual meeting, vol 1. Society of Magnetic Resonance in Medicine, Berkeley, p 143Google Scholar
- Perkin GD, Rose FC (1979) Optic neuritis and its differential diagnosis. Oxford University Press, OxfordGoogle Scholar
- Thompson AJ, Miller DH (1992) Magnetic resonance imaging in clinical practice. In: Kennard C (ed) Recent advances in clinical neurology, vol 7. Churchill Livingstone, London, pp 199–219Google Scholar
- Youl BD (1992) Magnetic resonance imaging studies of optic neuritis [thesis]. University of Melbourne, MelbourneGoogle Scholar