The diagnosis of HCL rests on the identification of HCs; a combination of characteristics — typical nuclear, membrane and cytoplasmic features — should be sought.
The membrane hairs are the most obvious feature and are distinguished from those in other conditions by their frequency and fine nature. However, hairs may be absent from some or occasionally most HCs.
The principal cytochemical feature of HCs is TRAP, and 95% of cases show strong positivity in some or all HCs. Weak TRAP reactivity may occur in related conditions.
KeywordsSurface Projection Hairy Cell Cortical Actin Myeloid Growth Factor Cortical Actin Network
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