Corticosterone and the hypothalamic-pituitary-adrenal (HPA) axis in autoimmune diseases

  • Francisco Ramírez
  • Don Mason

Abstract

Antigen-specific immune responses, which have evolved to protect the mammalian host from disease-causing organisms, are elicited when lymphocytes recognize pathogen-derived antigens and receive simultaneously the appropriate co-stimuli from the antigen-presenting cell. Following the initial triggering steps the immune system can activate a variety of effector mechanisms to eliminate or control the pathogenic organisms that produce the antigens in question. The activation and the development of effector mechanisms are complex events which require the participation of many components of the immune system. As many of the biological parameters are susceptible to genetic variation, it is not surprising that inbred strains of laboratory animals differ strikingly in the way that they respond to various antigens. The differences concern two aspects of immunity.

Keywords

Arthritis Corticosteroid Hydrocortisone Tuberculosis Interferon 

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© Springer-Verlag London Limited 1997

Authors and Affiliations

  • Francisco Ramírez
  • Don Mason

There are no affiliations available

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