WERNICKE, Carl

1848–1904
  • Peter Beighton
  • Greta Beighton

Abstract

WERNICKE disease, or encephalopathy, comprises mental confusion, paralysis of the external ocular muscles, nystagmus and ataxia. Although associated with alcoholism, thiamine deficiency in genetically predisposed persons is now regarded as the major determinant of the condition.

Keywords

Dementia Convolution Thiamine Pyrophosphate Aphasia 

References

  1. Blass JP, Gibson GE (1977) Abnormality of a thiamine-requiring enzyme in patients with Wernicke-Korsakoff syndrome. New Engl J Med 297:1367–1370PubMedCrossRefGoogle Scholar
  2. Blass JP, Gibson GE (1979) Genetic factors in Wernicke-Korsakoff syndrome. Alcoholism Clin Exp Res 3:126–134CrossRefGoogle Scholar
  3. Gayet M (1875) Affection encéphalique (Encéphalite diffuse probable). Localisée aux étages supérieurs des pédoncules cérébraux et aux couches optiques, ainsi qu’au plancher du quatrième ventricule et aux parois latérales du troisième. Observation recueillie. Arch Physiol Norm Path, Paris 2: 341–351Google Scholar
  4. Obituary (Siemerling) (1905) Arch Psychiat, Berl 40:1016–1019Google Scholar
  5. Obituary (Ziehen) (1905) Mschr Psychiat 18:1–4Google Scholar
  6. Wernicke C (1881) Die acute hämorrhagische Polioencephalitis superior. In: Lehrbuch der Gehirnkrankheiten. Fischer, Kassel, pp. 229–242Google Scholar

Copyright information

© Springer-Verlag London Limited 1997

Authors and Affiliations

  • Peter Beighton
    • 1
  • Greta Beighton
    • 1
  1. 1.Department of Human GeneticsUniversity of Cape Town Medical SchoolSouth Africa

Personalised recommendations