Abstract
The histologic hallmark of classical Hodgkin’s disease is the hiatus between the bizarre Reed-Sternberg cells (and their mononuclear variants) and the background infiltrate, which features a diversity of cellular elements [49.1] and [49.2]. This chapter considers types of Hodgkin’s disease other than “lymphocyte predominance” [49.3] starting with the lymphocyte-rich subgroup. This is not an entirely satisfactory term but it was adopted in the REAL classification to make a distinction from lymphocyte predominance disease.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Lukes RJ, Butler JJ, Hicks EB. Natural history of Hodgkin’s disease as related to its pathologic picture. Cancer 1966; 19: 317–344.
Lukes RJ, Craver RF, Hall TC, et al. Report of the nomenclature committee. Cancer 1966; 26: 1311.
Poppema S, Kaiserling E, Lennert K. Nodular paragranuloma and progressively transformed germinal centers. Ultrastructural and immunohistologic findings. Virchows Arch B Cell Pathol Incl Mol Pathol 1979; 31: 211–25.
Harris NL, Jaffe ES, Stein H et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994; 84: 1361–92.
Doggett RS, Colby TV, Dorfman RF. Interfollicular Hodgkin’s disease. Am J Surg Pathol 1983; 7: 145–9.
Lukes RJ, Butler JJ. The pathology and nomenclature of Hodgkin’s disease. Cancer Res 1966; 26: 1063–83.
Jackson H. and Parker H. Hodgkin’s Disease and Allied Disorders. New York: Oxford University Press 1947; 28–33.
Küppers R, Rajewsky K, Zhao M et al. Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci USA 1994; 91: 10962–6.
Further Reading
Banks PM. The pathology of Hodgkin’s disease. Sem Oncol 1990; 17: 683–95.
Butler JJ. The histologic diagnosis of Hodgkin’s disease. Semi Diag Pathol 1992; 9: 252–6.
Gulley ML, Eagan PA, Quintanilla-Martinez L et al. Epstein-Barr virus DNA is abundant and monoclonal in the Reed-Sternberg cells of Hodgkin’s disease: Associated with mixed cellularity subtype and Hispanic American ethnicity. Blood 1994; 83: 1595–602.
Hummel M, Ziemann K, Lammert H, Pileri S, Sabattini E, Stein H. Hodgkin’s disease with monoclonal and polyclonal populations of Reed-Sternberg cells. N Engl J Med 1995; 333: 901–6.
Kamel OW, Chang PP, Hsu FJ et al. Clonal VDJ recombination of the immunoglobulin heavy chain gene by PCR in Classical Hodgkin’s disease. Am J Clin Pathol 1995; 104: 419–23.
McBride JA, Rodriguez J, Luthra R, Ordóñez, Cabanillas F, Pugh WC.T-cell-rich B large-cell lymphoma simulating lymphocyte-rich Hodgkin’s disease. Am J Surg Pathol 1996; 20: 193–201.
MacLennan KA, Bennett MH, Tu A et al. Relationship of histopathologic features to survival and relapse in nodular sclerosing Hodgkin’s disease. A study of 1659 patients. Cancer 1989; 64: 1686–93.
Patsouris E, Noël H, Lennert K. Cytohistologic and immunohisto-chemical findings in Hodgkin’s disease, mixed cellularity type, with a high content of epithelioid cells. Am J Surg Pathol 1982; 13: 1014–22.
Weber-Matthiesen K, Deerberg J, Poetsch M, Grote W, Schlegelberger B. Numerical chromosome aberrations are present within the CD30+ Hodgkin and Reed-Sternberg cells in 100% of analyzed cases of Hodgkin’s disease. Blood 1995; 86: 1464–8.
Weiss LM, Lopategui JR, Sun L-H, Kamel OW, Koo CH, Glackin C. Absence of the t(2;5) in Hodgkin’s disease. Blood 1995; 85: 2845–7.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer-Verlag London
About this chapter
Cite this chapter
Banks, P.M. (1999). Morphologic, immunologic and genetic features of “Classical” Hodgkin’s disease. In: Mason, D.Y., Harris, N.L. (eds) Human Lymphoma: Clinical Implications of the REAL Classification. Springer, London. https://doi.org/10.1007/978-1-4471-0857-3_49
Download citation
DOI: https://doi.org/10.1007/978-1-4471-0857-3_49
Publisher Name: Springer, London
Print ISBN: 978-1-4471-1218-1
Online ISBN: 978-1-4471-0857-3
eBook Packages: Springer Book Archive