Hepatosplenic gamma delta T cell lymphoma

  • E. S. Jaffe


This rare disorder was initially listed in the REAL classification as a provisional malignancy, because very few reports had been published at that time, but there is certainly now convincing evidence that it is a distinctive sub-type of lymphoma. It was initially described by Farcet and colleagues in 1990 as a “hepatosplenic T-cell lymphoma”.1 They identified several patients presenting with striking hepatosplenomegaly and a unique type of T cell lymphoma.


Cell Lymphoma Large Granular Lymphocyte Human Lymphoma Neutrophil Leukocytosis Produce Interferon Gamma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Farcet JP, Gaulard P, Marolleau J et al. Hepatosplenic T-cell lymphoma: sinusal/sinusoidal localization of malignant cells expressing the T-cell receptor γδ. Blood 1990; 75: 2213–9.PubMedGoogle Scholar
  2. 2.
    Cooke CB, Krenacs L, Stetler-Stevenson M et al. Hepatosplenic T-cell lymphoma: a distinct clinicopathologic entity of cytotoxic γδ T-cell origin. Blood 1996; 88:4265–74.PubMedGoogle Scholar
  3. 3.
    Wang CC, Tien HF, Lin MT et al. Consistent presence of isochromosome 7q in hepatosplenic T gamma/delta lymphoma: a new cytogenetic-clinicopathologic entity. Genes Chromosom Cancer 1995; 12: 161–4.PubMedCrossRefGoogle Scholar
  4. 4.
    Alonsozana EL, Stamberg J, Kumar D et al. Isochromosome 7q: the primary cytogenetic abnormality in hepatosplenic γδ T-cell lymphoma. Leukemia 1997; 11:1367–72.PubMedCrossRefGoogle Scholar

Further Reading

  1. Burg G, Dummer R, Wilhelm M et al. A subcutaneous delta-positive T-cell lymphoma that produces interferon gamma. N Engl J Med 1991; 325: 1078–81.PubMedCrossRefGoogle Scholar
  2. Ross CW, Schnitzer B, Sheldon S, Braun DK, Hanson CA. Gamma/delta T-cell post transplantation lymphoproliferative disorder primarily in the spleen. Am J Clin Pathol 1994; 102:310–5.PubMedGoogle Scholar

Copyright information

© Springer-Verlag London 1999

Authors and Affiliations

  • E. S. Jaffe

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