Hepatosplenic gamma delta T cell lymphoma

  • E. S. Jaffe


This rare disorder was initially listed in the REAL classification as a provisional malignancy, because very few reports had been published at that time, but there is certainly now convincing evidence that it is a distinctive sub-type of lymphoma. It was initially described by Farcet and colleagues in 1990 as a “hepatosplenic T-cell lymphoma”.1 They identified several patients presenting with striking hepatosplenomegaly and a unique type of T cell lymphoma.


Lymphoma Leukemia Anemia Interferon Thrombocytopenia 


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  1. 1.
    Farcet JP, Gaulard P, Marolleau J et al. Hepatosplenic T-cell lymphoma: sinusal/sinusoidal localization of malignant cells expressing the T-cell receptor γδ. Blood 1990; 75: 2213–9.PubMedGoogle Scholar
  2. 2.
    Cooke CB, Krenacs L, Stetler-Stevenson M et al. Hepatosplenic T-cell lymphoma: a distinct clinicopathologic entity of cytotoxic γδ T-cell origin. Blood 1996; 88:4265–74.PubMedGoogle Scholar
  3. 3.
    Wang CC, Tien HF, Lin MT et al. Consistent presence of isochromosome 7q in hepatosplenic T gamma/delta lymphoma: a new cytogenetic-clinicopathologic entity. Genes Chromosom Cancer 1995; 12: 161–4.PubMedCrossRefGoogle Scholar
  4. 4.
    Alonsozana EL, Stamberg J, Kumar D et al. Isochromosome 7q: the primary cytogenetic abnormality in hepatosplenic γδ T-cell lymphoma. Leukemia 1997; 11:1367–72.PubMedCrossRefGoogle Scholar

Further Reading

  1. Burg G, Dummer R, Wilhelm M et al. A subcutaneous delta-positive T-cell lymphoma that produces interferon gamma. N Engl J Med 1991; 325: 1078–81.PubMedCrossRefGoogle Scholar
  2. Ross CW, Schnitzer B, Sheldon S, Braun DK, Hanson CA. Gamma/delta T-cell post transplantation lymphoproliferative disorder primarily in the spleen. Am J Clin Pathol 1994; 102:310–5.PubMedGoogle Scholar

Copyright information

© Springer-Verlag London 1999

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  • E. S. Jaffe

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