What Are the Risks of Thrombophilia?
Deep vein thrombosis of the leg (DVT), whether symptomatic or asymptomatic, is a common cause of venous insufficiency (calf pump failure syndrome): when there is evidence of previous DVT from the history or at venography the term “post- thrombotic syndrome” is used . The incidences of the post-thrombotic syndrome, and of recurrent DVT, in a large, prospective observational study were recently reported . The cumulative incidence of recurrence following conventional treatment of acute DVT with heparin followed by 3 months of warfarin was 17.5% after 2 years, 25% after 5 years and 30% after 8 years. The cumulative incidence of the post-thrombotic leg syndrome was 23%, 28% and 29% respectively, and was strongly associated with ipsilateral recurrent DVT. Recurrence was associated positively with thrombophilias and with malignant disease, and negatively with DVT following recent trauma, fracture or surgery .
KeywordsDeep Vein Thrombosis Factor Versus Population Attributable Risk Venous Insufficiency Factor Versus Leiden Mutation
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Browse NL, Burnand KG, Lea Thomas M. Diseases of the veins: pathology, diagnosis and treatment. London: Edward Arnold, 1988.Google Scholar
Prandoni P, Lensing AWA, Cogo A, et al. The long-term clinical course of acute deep venous thrombosis. Ann Intern Med 1996;125:1–7.PubMedGoogle Scholar
Lowe GDO. Venous thromboembolism. In: Pathy MSJ, editor. Principles and practice of geriatric medicine. Chichester: Wiley, 1998.Google Scholar
Lane DA, Mannucci PM, Bauer KA, et al. Inherited thrombophilia. Thromb Haemost 1996;76:651–662, 824-834.PubMedGoogle Scholar
British Committee for Standards in Haematology. Guidelines on the investigation and management of thrombophilia. J Clin Pathol 1990;43:703–709.CrossRefGoogle Scholar
Koster T. Deep-vein thrombosis. A population-based case-control study: Leiden Thrombophilia Study. MD Thesis, University of Leiden, 1995.Google Scholar
Ridker PM, Glynn RJ, Miletich JP, Goldhaber SZ, Stampfer MJ, Hennekens CH. Age-specific incidence rates of venous thromboembolism among heterozygous carriers of Factor V Leiden mutation. Ann Intern Med 1997;126:528–531.PubMedGoogle Scholar
Goldhaber SZ, Savage DD, Garrison RJ, et al. Risk factors for pulmonary embolism: the Framingham Study. Am J Med 1983;74:1023PubMedCrossRefGoogle Scholar
Woodward M, Lowe GDO, Rumley A, et al. Epidemiology of coagulation factors, inhibitors and activation markers: the Third Glasgow MONICA Survey. II. Relationships to cardiovascular risk factors and prevalent cardiovascular disease. Br J Haematol 1997;97:785–797.PubMedCrossRefGoogle Scholar
Lowe GDO, Rumley A, Woodward M, Reid E. Oral contraceptives and venous thromboembolism. Lancet 1997;349:1623.PubMedCrossRefGoogle Scholar
Thromboembolic Risk Factors (THRIFT) Consensus Group. Risk of and prophylaxis for venous thromboembolism in hospital patients. BMJ 1992;305:567–574.CrossRefGoogle Scholar
Vandenbroucke JP, Rosendaal FR. End of the line for “third-generation” pill controversy? Lancet 1997;349:1113–1114.PubMedCrossRefGoogle Scholar
Vandenbroucke JP, Heimerhorst FM. Risk of venous thrombosis with hormone-replacement therapy. Lancet 1996;348:972.PubMedCrossRefGoogle Scholar
Baglin C, Brown K, Luddington R, Baglin T. Risk of recurrent venous thromboembolism in patients with the factor V Leiden (FVR506Q) mutation: effects of warfarin and prediction by predisposing factors. Br J Haematol 1998;100:764–768.PubMedCrossRefGoogle Scholar
Sarasin FP, Bounameaux H. Decision analysis model of prolonged anticoagulant treatment in factor V Leiden carriers with first episode of deep vein thrombosis. BMJ 1998;316:95–99.PubMedGoogle Scholar
Brandjes DP, Buller HR, Heijboer H, Huisman MV, de Rijk M, Jagt H, ten Cate JW. Randomised trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosis. Lancet 1997;349:759–762.PubMedCrossRefGoogle Scholar
Wadworth AN, Faulds D. Hydroxyethylrutosides: a review of its pharmacology, and therapeutic efficacy in venous insufficiency and related disorders. Drugs 1992;44:1013–1032.PubMedCrossRefGoogle Scholar
Chabanel A, Horellou MH, Conard J, Samama MM. Red blood cell aggregability in patients with a history of leg vein thrombosis: influences of post-thrombotic treatment. Br J Haematol 1994;88:174–179.PubMedCrossRefGoogle Scholar
Chabanel A, Zuccarelli F, Samama MM. Red cell aggregability increases with the severity of venous insufficiency. Int Angiol 1995;14:69–73.PubMedGoogle Scholar
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