What Are the Risks of Thrombophilia?

  • Gordon D. O. Lowe
  • Ann Rumley


Deep vein thrombosis of the leg (DVT), whether symptomatic or asymptomatic, is a common cause of venous insufficiency (calf pump failure syndrome): when there is evidence of previous DVT from the history or at venography the term “post- thrombotic syndrome” is used [1]. The incidences of the post-thrombotic syndrome, and of recurrent DVT, in a large, prospective observational study were recently reported [2]. The cumulative incidence of recurrence following conventional treatment of acute DVT with heparin followed by 3 months of warfarin was 17.5% after 2 years, 25% after 5 years and 30% after 8 years. The cumulative incidence of the post-thrombotic leg syndrome was 23%, 28% and 29% respectively, and was strongly associated with ipsilateral recurrent DVT. Recurrence was associated positively with thrombophilias and with malignant disease, and negatively with DVT following recent trauma, fracture or surgery [2].


Deep Vein Thrombosis Factor Versus Population Attributable Risk Venous Insufficiency Factor Versus Leiden Mutation 
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© Springer-Verlag London Limited 1999

Authors and Affiliations

  • Gordon D. O. Lowe
  • Ann Rumley

There are no affiliations available

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