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What Are the Risks of Thrombophilia?

  • Gordon D. O. Lowe
  • Ann Rumley

Abstract

Deep vein thrombosis of the leg (DVT), whether symptomatic or asymptomatic, is a common cause of venous insufficiency (calf pump failure syndrome): when there is evidence of previous DVT from the history or at venography the term “post- thrombotic syndrome” is used [1]. The incidences of the post-thrombotic syndrome, and of recurrent DVT, in a large, prospective observational study were recently reported [2]. The cumulative incidence of recurrence following conventional treatment of acute DVT with heparin followed by 3 months of warfarin was 17.5% after 2 years, 25% after 5 years and 30% after 8 years. The cumulative incidence of the post-thrombotic leg syndrome was 23%, 28% and 29% respectively, and was strongly associated with ipsilateral recurrent DVT. Recurrence was associated positively with thrombophilias and with malignant disease, and negatively with DVT following recent trauma, fracture or surgery [2].

Keywords

Deep Vein Thrombosis Factor Versus Population Attributable Risk Venous Insufficiency Factor Versus Leiden Mutation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag London Limited 1999

Authors and Affiliations

  • Gordon D. O. Lowe
  • Ann Rumley

There are no affiliations available

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