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Perinatal Viral Infections as a Cause of Intrauterine Growth Restriction

  • Chapter
Intrauterine Growth Restriction

Abstract

IUGR is a major cause of perinatal morbidity and mortality; indeed with increasing incidence of detection and “salvage” of the very low birthweight fetus such complications will continue to rise [1].

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References

  1. Ounsted M, Moar V, Scott WA. Perinatal morbidity and mortality in small-for-dates babies: the relative importance of some maternal factors. Early Hum Dev 1981;5:367–9.

    Article  PubMed  CAS  Google Scholar 

  2. Teberg AJ, Walther FJ, Pena IC. Mortality, morbidity and outcome of small for gestational age infants. Semin Perinatol 1988;11:84–9.

    Google Scholar 

  3. Lin C-C, Su S-J, River LP. Comparisons of associated high risk factors and perinatal outcome between symmetric and asymmetric fetal intrauterine growth retardation. Am J Obstet Gynecol 1991;164:1535–9.

    PubMed  CAS  Google Scholar 

  4. Klein JO, Remington JS, Marcy SM. Current concepts of infection of the fetus and newborn. In: Remington JS, Klein JO, editors. Infectious disease of the fetus and newborn, 3rd edn, ch. 1. Philadelphia: WB Saunders, 1990;11–15.

    Google Scholar 

  5. Krebs C, Macara LM, Leiser R, Bowman AW, Greer IA, Kingdom JC. Intrauterine growth restriction with absent end diastolic flow velocity in the umbilical artery is associated with mal- development of the placental terminal villous tree. Am J Obstet Gynecol 1996;175:1534–42.

    Article  PubMed  CAS  Google Scholar 

  6. Benirschke K, Kaufmann P, editors. Pathology of the human placenta, 3rd edn. London: Springer- Verlag, 1995.

    Google Scholar 

  7. Alford CA, Stagno S, Pass RF, Britt WJ. Congenital and perinatal cytomegalovirus infection. Rev Infect Dis 1990;12:S745–53.

    Article  PubMed  Google Scholar 

  8. Banatavala JE ,Best JM. Rubella in Topley and Wilson’s principles of bacteriology, virology and immunology, 8th edn, vol 4.1991.

    Google Scholar 

  9. Best JM, Banatvala JE. Rubella. In: Zuckerman AJ, Banatvala JE, Patterson JR, editors. Principles and practice of clinical virology, 3rd edn,ch. 11. Chichester: John Wiley, 1995;363–400.

    Google Scholar 

  10. Alford CA Jr.Rubella. In: Remington JS, Klein JO, editors. Infectious diseases of the fetus and newborn. Philadelphia:WB Saunders, 1976;356–8.

    Google Scholar 

  11. Bart SW, Steller HC, Prebuld SR. Fetal risk associated with rubella vaccine: an update. Rev Infect Dis 1985;7:595–9.

    Google Scholar 

  12. Harrison CJ, Myers MG. Relation of maternal CMV viraemia and antibody response to the rate of congenital infection and intrauterine growth restriction. J Med Virol 1990;31:222–8.

    Article  PubMed  CAS  Google Scholar 

  13. Balducci J, Rodis JF, Rosengren S. Pregnancy outcome following first trimester varicella infection. Obstetr Gynaecol 1992;79:5–9.

    CAS  Google Scholar 

  14. Bulterys M, Chao A, Munyemana S, Kurawige JB, Nawrocki P. Maternal human immunodeficiency virus I infection and intrauterine growth: a prospective cohort study in Butare, Rwanda. Paediatr Infect Dis J 1994;13:94–100.

    Article  CAS  Google Scholar 

  15. Creasy RK, Resnik R (1994) Intrauterine growth restriction. In: Maternal fetal medicine. Principles and practice, 3rd edn, ch. 36. Philadelphia: WB Saunders, 1994;561.

    Google Scholar 

  16. Branch DW, Scott JR. Immunology of pregnancy. In: Creasy RK, Resnik R, editors. Maternal-fetal medicine principles and practice, 3rd edn, ch. 6. Philadelphia: WB Saunders, 1994; 115–27.

    Google Scholar 

  17. Bennett P, Nicolini U. Fetal infections: In: Fisk MN, Moise KJ, editors. Fetal therapy: invasive and transplacental, ch. 8. Cambridge: Cambridge University Press, 1997;92–116.

    Google Scholar 

  18. Morell A, Sidiropoulos D, Herrmann U. IgG sub-classes in antibodies to group B streptococci, pneumococci and tetanus toxoid in pre-term neonates after intravenous infusions of immunoglobulins to the mother. Paediatr Res 1986;20:933–6.

    Article  CAS  Google Scholar 

  19. Weiler TH. The cytomegaloviruses: the difficult years. J Infect Dis 1970;122:532–9.

    Article  Google Scholar 

  20. Grose C, Weiner CP. Prenatal diagnosis of congenital cytomegalovirus infection: Two decades later. Am J Obstet Gynecol 1990;163:447–50.

    PubMed  CAS  Google Scholar 

  21. Hanshaw JB. Congenital cytomegalovirus infection: a fifteen year prospective study. J Infect Dis 1971;123:555–9.

    Article  PubMed  CAS  Google Scholar 

  22. Hanshaw JB, Scheiner AP, Moxley AW. School failure and deafness after “silent” congenital cytomegalovirus infection. N Engl J Med 1976;295:468–71.

    Article  PubMed  CAS  Google Scholar 

  23. Ryan M, Miller E, Waight P. Public Health Laboratory Survey: Communicable disease report. Cytomegalovirus infection in England and Wales: 1992 and 1993. London: Public Health Laboratory, 1995; R74–6.

    Google Scholar 

  24. Stagno S, Pass RF, Cloud G, Britt WJ, Henderson RE, Walton PD, et al. Primary cytomegalovirus infection in pregnancy: Incidence, transmission to fetus and clinical outcome. JAMA 1986;256:1904–8.

    Article  PubMed  CAS  Google Scholar 

  25. Balfour CL, Balfour HH. Cytomegalovirus is not an occupational risk for nurses in renal transplant and neonatal units. JAMA 1986;256:1909–12.

    Article  PubMed  CAS  Google Scholar 

  26. Chandler SH, Alexander ER, Holmes HE. Epidemiology of cytomegalovirus infection in a heterogenous population of pregnant women. J Infect Dis 1985;152:249–54.

    Article  PubMed  CAS  Google Scholar 

  27. Monif GRG, Egan EA, Held B. The correlation of maternal cytomegalovirus infection during varying stages of gestation and neonatal involvement. J Paediatr 1972;80:17–21.

    Article  CAS  Google Scholar 

  28. Stanier P, Kitchen AD, Taylor DL, Tyms AS. Detection of human cytomegalovirus in peripheral mononuclear cells and urine samples using polymerase chain reaction. Mol Cell Probes 1992;6:51–8.

    Article  PubMed  CAS  Google Scholar 

  29. Griffiths PD, Stagno S, Pass RF, Smith RJ, Alfred CA. Infection with cytomegalovirus in pregnancy: specific IgM antibodies as a marker of recent infection. J Infect Dis 1982;145:647–53.

    Article  PubMed  CAS  Google Scholar 

  30. Demmler GJ. Summary of a workshop on surveillance for congenital cytomegalovirus disease. Rev Infect Dis 1991;13:315–27.

    Article  PubMed  CAS  Google Scholar 

  31. Lamy ME, Mulongo KN, Gadisseux JF, Lyon G, Gaudey V, van Lierde M. Prenatal diagnosis of fetal cytomegalovirus infection. Am J Obstet Gynecol 1992;166:91–4.

    PubMed  CAS  Google Scholar 

  32. Stagno S, Pass RF, Dworsky ME, Alford CA. Maternal cytomegalovirus infection and perinatal transmission. Clin Obstet Gynaecol 1982;25:563–76.

    Article  CAS  Google Scholar 

  33. Tookey PA, Peckham CS. Cytomegalovirus. In: Greenhough A, Osbourne J, Sutherland S, editors. Congenital perinatal and neonatal infection. London: Churchill Livingstone, 1992;49–61.

    Google Scholar 

  34. Stern J, Tucker SM. Prospective study of cytomegalovirus infection in pregnancy. BMJ 1973;2:268–71.

    Article  PubMed  CAS  Google Scholar 

  35. Stagno S, Whitley RJ. Herpes virus infection in pregnancy. I: Cytomegalovirus and Epstein Barr Virus Infection. N Engl J Med 1985a;313:1270–4.

    CAS  Google Scholar 

  36. Ghidini A, Sirtori M, Regarni P, Marini S, Tucci E, Scola GC. Fetal intracranial calcifications. Am J Obstet Gynecol 1989;160:86–7.

    PubMed  CAS  Google Scholar 

  37. Estroff JA, Parad RB, Teele RL. Echogenic vessels in the fetal thalami and basal ganglia associated with cytomegalovirus infection. J Ultrasound Med 1992;11:687–8.

    Google Scholar 

  38. Fakhry J, Khoury A. Fetal intracranial calcifications - the importance of periventricular hypo- echogenic foci without shadowing. J Ultrasound Med 1991;10:51–4.

    PubMed  CAS  Google Scholar 

  39. Twickler DM, Perlman J, Maeberry MC. Congenital cytomegalovirus presenting as cerebral ventriculomegaly on antenatal ultrasonography. Am J Perinatol 1993;10:404–6.

    Article  PubMed  CAS  Google Scholar 

  40. Drose JA, Dennis MA, Thickman D. Infection in-utero; ultrasound findings in 19 cases. Radiology 1991;178:369–74.

    PubMed  CAS  Google Scholar 

  41. Forouzan I. Fetal abdominal echogenic mass: an early sign of intrauterine cytomegalovirus infection. Obstet Gynaecol 1992;80:535–7.

    CAS  Google Scholar 

  42. Monteagudo A, Matera C, Marx F. In-utero sonographic diagnosis of congenital cytomegalovirus infection. Society of Perinatal Obstetrics - 10th Annual Meeting, Houston, Texas, 1990;326 [abst]

    Google Scholar 

  43. Amirhessami-Aghili N, Manaio P, Hall MR, Tibbits FD, Ort CA, Afsari A (1987). Human CMV infection of human placental expiants in culture. Am J Obstet Gynecol. 156:1365–74.

    PubMed  CAS  Google Scholar 

  44. Liu B, Tao W, Liu D. The relationship between placental pathology and certain pathogens detected in paraffin embedded tissues in cases of intrauterine growth restriction. Chin J Obstet Gynaecol 1996;31:90–2.

    CAS  Google Scholar 

  45. Ljubic A, Cvetkovic M, Sulovic V, Novakov A, Kokai D, Bujko M, et al. Essential and non-essential amnio acids in appropriate and small for gestational age fetuses with congenital cytomegalovirus infection. Clin Exp Obstet Gynaecol 1997;24:207–8.

    Google Scholar 

  46. Pass RF, Stanno S, Myers GJ. Outcome of symptomatic congenital cytomegalovirus infection; results of long term longitudinal follow up. Pediatrics 1980;66:758–62.

    PubMed  CAS  Google Scholar 

  47. Peckham CS, Johnson C, Ades A, Pearl K, Chin KS. Early acquisition of cytomegalovirus infection. Arch Dis Child 1987;62:780–5.

    Article  PubMed  CAS  Google Scholar 

  48. Preece PM, Pearl KN, Peckham CS. Congenital cytomegalovirus infection. Arch Dis Child 1984;59:1120.

    Article  PubMed  CAS  Google Scholar 

  49. Lynch L, Daffos F, Emanuel D, Giovangrandi Y, Meisel R, Forestirer F, Cathomas G, Berkowitz RL. Prenatal diagnosis for cytomegalovirus infection. Am J Obstet Gynecol 1991;156:714–18.

    Google Scholar 

  50. Nicolini U, Kustermann A, Tassis B, Fogliani R, Fogliani R, Gamberti A, et al. Prenatal diagnosis of congenital human cytomegalovirus. Prenat Diagn 1994;14:903–6.

    Article  PubMed  CAS  Google Scholar 

  51. Hohlfeld P, Daffos F, Costa JM, Thulliez P, Forestirer F, Vidaud M. Prenatal diagnosis of congenital toxoplasmosis with a polymerase chain reaction test in amniotic fluid. N Engl J Med 1994;331:695–9.

    Article  PubMed  CAS  Google Scholar 

  52. Wen L, Wu S, Lu S. The epidemiological study of human cytomegalovirus infection of pregnant women and the maternal fetal transmission in 3 Chinese metropolis. Chin J Obstet Gynaecol 1996;31:714–17.

    CAS  Google Scholar 

  53. Ruellan-Eugene G, Barjot P, Campet M, Vabret A, Herlicoviez M, Muller G, et al. The evaluation of virological procedures to detect fetal human cytomegalovirus infection; avidity of IgG antibodies, virus detection in amniotic fluid and maternal serum. J Med Virol 1996;50:9–15.

    Article  PubMed  CAS  Google Scholar 

  54. Revello MG, Baldanti F, Furione M, Sarasini A, Percivalle E, Zavattoin M, et al. Polymerase chain reaction for prenatal diagnosis of human congenital cytomegalovirus infection. J Med Virol 1995;47:462–6.

    Article  PubMed  CAS  Google Scholar 

  55. Hagay ZY, Biran G, Ornoy A, Reece EA. Congenital cytomegalovirus infection: a longstanding problem still seeking a solution. Am J Obstet Gynecol 1996;174:241–5.

    Article  PubMed  CAS  Google Scholar 

  56. Einsele H, Eininger G, Steidle M, Vallbracht A, Mueller M, Schmidt H, et al. Polymerase chain reaction to evaluate antiviral therapy for cytomegalovirus. Lancet 1991;338:1170–2.

    Article  PubMed  CAS  Google Scholar 

  57. Revello MG, Percivalle E, Baldanti F. Prenatal treatment of congenital human cytomegalovirus infection by intravascular administration of Ganciclovir to the fetus. Clin Diagn Virol 1993;1:61–7.

    Article  Google Scholar 

  58. Fisk NM, Moise KJ, editors. Fetal therapy: invasive and transplacental. Cambridge: Cambridge University Press, 1997.

    Google Scholar 

  59. Collaborative DHPG treatment study group: treatment of serious cytomegalovirus infection with 9-(1–3-dihydroxypropoxymethyl) quanine in a patient with AIDS and other deficiencies. N Engl J Med 1986;314:801–3.

    Article  Google Scholar 

  60. Merigan TC, Runlund DG, Keay S. A controlled trial of Ganciclovir to prevent cytomegalovirus disease after heart transplantation. N Engl J Med 1992;326:1182–3.

    Article  PubMed  CAS  Google Scholar 

  61. Miller E, Maight PA, Vurdien JE. Rubella surveillance to December 1992: Second joint report from the PHLS and national rubella surveillance programme. CDR Rev 1993;3:R35–40.

    CAS  Google Scholar 

  62. Hermann KL. Available rubella serological tests. Rev Obstet Dis 1985;7:S109.

    Google Scholar 

  63. Sidle N. Rubella in pregnancy. London: SENSE, 1985.

    Google Scholar 

  64. Best JM, O’Shea S. Rubella virus. In: Schmidt N, Emmons RW, editors. Diagnostic procedures for viral rickettsial and chlamydial infections, 6th edn. Washington DC: American Public Health Association, 1989.

    Google Scholar 

  65. Morgan-Capner P, Miller A, Vurdien JE, Ramsay MEB. Outcome of pregnancy after maternal reinfection with rubella. CDR Rev 1991;l:R57–9.

    Google Scholar 

  66. Gregg NM. Cataract following German measles in the mother. Trans Ophth Soc Aust 1941;3:34–6.

    Google Scholar 

  67. Horn LC, Buttner W, Horn E (1993). Rotelnbedingte Plazentaveranderungen. Perinatal Med. 5:5–10.

    Google Scholar 

  68. Ender G, Nickerl-Pacher U, Muller E, Craddock-Watson JE. Outcome of confirmed preconceptual maternal rubella. Lancet 1988;i: 1445–7.

    Google Scholar 

  69. Ornoy A, Segal S, Nishmi M, Simcha A, Polishuk W. Fetal and placental pathology in gestational rubella. Am J Obstet Gynecol 1973;116:949–56.

    PubMed  CAS  Google Scholar 

  70. Daffos F, Forestier F, Grangeot-Keros L, Pavlovsky MC, Lebon P, Chartier M, et al. Prenatal diagnosis of congenital rubella. Lancet 1984;ii:l–3.

    Google Scholar 

  71. Morgan-Capner P. The detection of rubella specific antibody. Public Health Lab Serv Microbiol Dig 1983;1:6–11.

    Google Scholar 

  72. Stagno S, Whitney RJ. Herpes virus infection of pregnancy. 2. Herpes simplex virus and varicella zoster virus infection. N Engl J Med 1985b;313:1327–30.

    CAS  Google Scholar 

  73. Smego RA, Asperilla MO. Use of Acyclovir for varicella pneumonia during pregnancy. Obstet Gynaecol 1991;78:1112–15.

    Google Scholar 

  74. Pastuszak AL, Levy M, Schick B, Zuber C, Feldkamp M. Outcome after maternal varicella infection in the first 20 weeks of pregnancy. N Engl J Med 1994;330:901–5.

    Article  PubMed  CAS  Google Scholar 

  75. Alkalay AL, Pomerance JJ, Rimoin DL. Fetal varicella syndrome. J Pediatr 1987;111:320–3.

    Article  PubMed  CAS  Google Scholar 

  76. Pretorius DH, Haywood I, Jones KL. Sonographic evaluation of pregnancies with maternal varicella infection. J Ultrasound Med 1992;11:459–63.

    PubMed  CAS  Google Scholar 

  77. Department of Health, Welsh Office, Scottish Home and Health Departments. Immunization against infectious disease. London: HMSO, 1990.

    Google Scholar 

  78. Davison AJ, Scott JE. The complete DNA sequence of varicella zoster virus. J Genet Virol 1986;67:1759–78.

    Article  CAS  Google Scholar 

  79. Lewis SH, Reynolds-Kohler C, Fox HE, Nelson JA. HIV I in trophoblastic and villus Hofbauer cells and haematological precursors in the eight week fetus. Lancet 1990;335:565–8.

    Article  PubMed  CAS  Google Scholar 

  80. Sever JL. HIV biology and immunology. ClinObstet Gynaecol 1989;32:423–39.

    CAS  Google Scholar 

  81. Barton JJ, O’Connor TM, Cannon MJ, Weldon-Linne CM. Prevalence of human immunodeficiency virus in the general prenatal population. Am J Gynecol 1989;160:1316–24.

    CAS  Google Scholar 

  82. European Collaborative Study. Risk factors for mother to child transmission of HIV Lancet 31992;39:1007–12.

    Google Scholar 

  83. European Collaborative Study. Caesarean section and the risk of vertical tranmission of HIV I infection. Lancet 1994;343:1464–7.

    Article  Google Scholar 

  84. Brandt CD, Rakusan TA, Sisson AV, Saxena ES, Ellaurie M, Sever JL. Human immunodeficiency virus infection in infants during the first two months of life: reliable detection and evidence of in- utero transmission. Arch Paediatr Adolesc Med 1994;148:250–4.

    Article  CAS  Google Scholar 

  85. Mundey DC, Schinazi RF, Gerber AR, Nahmias AJ, Randle HW. The human deficiency virus isolated from amniotic fluid. Lancet 1987;2:459–60.

    Article  Google Scholar 

  86. Hill RC, Bolton V, Carlson JR. Isolation of acquired immune deficiency syndrome virus from the placenta. Am J Obstet Gynecol 1987;157:10–13.

    PubMed  CAS  Google Scholar 

  87. Jauniaux E, Nessmann C, Imbert MC, Meuris S, Puissant F, Hustin J. Morphological aspects of placenta in HIV pregnancies. Placenta 1988;9:633–42.

    Article  PubMed  CAS  Google Scholar 

  88. Kalter SS, Helmke RJ, Heberling RL, Panigel M, Fowler AK, Strickland JE, et al. C type particles in normal human placenta. J Natl Cancer Inst 1973;50:1081–3.

    PubMed  CAS  Google Scholar 

  89. Horton R. Women as women with HIV. Lancet 1995;345:531–2.0.

    Google Scholar 

  90. Moodley D, Bobat RA, Cautsoudis A, Coovadia HM. Caesarean section and vertical transmission of HIV-1. Lancet 1994;334:338.

    Article  Google Scholar 

  91. Connor EM, Sperling RS, Gelber R, Kiselev P, Scott G, O’Sullivan MJ, et al. Reduction of maternal- infant transmission of HIV type I with Zidovudin treatment. N Engl J Med 1994;331:1173–80.

    Article  PubMed  CAS  Google Scholar 

  92. Concorde Co-ordinating Committee, Concorde, MRC/ANRS. Randomised double-blind controlled trial of immediate and deferred Zidovudin in symptom free HIV. Lancet 1994;343:871–81.

    Google Scholar 

  93. [Anonymous]. A positive response to perinatal HIV. Lancet 1999;353:511–12.

    Google Scholar 

  94. Leonova ES, Karmysheva V, Siannikova NV. Characteristics of experimental alpha virus infection during pregnancy and in the early stages of ontogeny in mice. Vopr Virusol 1983;28:53–9.

    PubMed  CAS  Google Scholar 

  95. Ando Y. Studies on the placental damage and intrauterine growth restriction caused by intra- vaginal inocculated herpes simplex virus type 2 during pregnancy. Acta Obstetr Gynaecol Japon 1981;33:681–9.

    CAS  Google Scholar 

  96. Duffell SJ, Sharp MW, Winkler CE, Terlecki S, Richardson C, Done JT, et al. Bovine virus diarrhoea — mucosal disease virus; induced fetopathy in cattle. Efficacy of prophylactic maternal preexposure. J Vet. Sci 1984;68:192–5.

    Google Scholar 

  97. Done JT, Terlecki S, Richardson C, Harkness JW, Sands JJ, Paterson DS, et al. Bovine virus, diarrhoea — mucosal disease virus: pathogenicity for fetal calf following maternal infection. Vet Ree 1980;106:473–9.

    Article  CAS  Google Scholar 

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Authors
  1. Mark Kilby
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  2. Sheena Hodgett
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Editors and Affiliations

  1. Maternal-Fetal Medicine, Mount Sinai Hospital, Suite 775B, University of Toronto, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada

    John Kingdom MD FRCS MRCP MRCOG

  2. School of Human Development, City Hospital, Nottingham University, Hucknall Road, NG5 1PB, Nottingham, UK

    Philip Baker BM BS MRCOG

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Kilby, M., Hodgett, S. (2000). Perinatal Viral Infections as a Cause of Intrauterine Growth Restriction. In: Kingdom, J., Baker, P. (eds) Intrauterine Growth Restriction. Springer, London. https://doi.org/10.1007/978-1-4471-0735-4_3

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  • DOI: https://doi.org/10.1007/978-1-4471-0735-4_3

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