A Discrete Model of Cellular/Humoral Responses
The IMMSIM model of the immune system, an automaton that simulates discrete encounters and cell-cell/cell-molecule interactions, has been extended to include both humoral and cell-mediated responses. This article describes and analyses the responses against a family of infective, cytopathic viruses obtained by varying three parameters at random. Depending on the composition of the virus experimental runs end in cure, or death, with differential engagement of the two branches of the immune system, which appear to cooperate but also to compete with each other.
KeywordsCellular Automaton Affinity Maturation Free Virus Idiotypic Network Dendritic Antigen Present Cell
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