A Discrete Model of Cellular/Humoral Responses

  • R. Puzone
  • B. Kohler
  • P. Seiden
  • F. Celada
Conference paper

Abstract

The IMMSIM model of the immune system, an automaton that simulates discrete encounters and cell-cell/cell-molecule interactions, has been extended to include both humoral and cell-mediated responses. This article describes and analyses the responses against a family of infective, cytopathic viruses obtained by varying three parameters at random. Depending on the composition of the virus experimental runs end in cure, or death, with differential engagement of the two branches of the immune system, which appear to cooperate but also to compete with each other.

Keywords

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Copyright information

© Springer-Verlag London Limited 2001

Authors and Affiliations

  • R. Puzone
    • 1
  • B. Kohler
    • 2
  • P. Seiden
    • 3
  • F. Celada
    • 2
    • 4
  1. 1.Nat. Inst. Cancer ResearchGenoaItaly
  2. 2.Hospital for Joint DiseasesNYUNew YorkUSA
  3. 3.IBM Research CenterYorktown HeightsUSA
  4. 4.University of GenoaItaly

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