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Calcium in Internal Medicine pp 225–259Cite as

Parathyroid Hormone Toxicity in Chronic Renal Failure

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Abstract

One of the major hormonal disturbances in uraemia is the state of secondary hyperparathyroidism and the elevation in blood levels of parathyroid hormone (PTH) [1]. In an editorial published in 1977, Massry suggested that the state of chronic excess of PTH in patients with chronic renal failure (CRF) may exert a widespread adverse effect on many organs, and that PTH may be a uraemic toxin [2]. Indeed, the available evidence shows that PTH satisfies the strict criteria of a uraemic toxin in that its nature and structure is known, its blood levels are elevated, a relationship between it and the uraemic manifestation(s) exists, an improvement in many signs and symptoms of uraemia follows a reduction in its blood levels, and the administration of PTH to experimental animals with normal renal function produces derangements similar to those seen in uraemic patients.

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Authors
  1. S. G. Massry
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  2. M. Smogorzewski
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Editors and Affiliations

  1. 2nd Department of Internal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, 545-8585, Abeno-ku Osaka, Japan

    Hirotoshi Morii MD, PhD (Professor Emeritus) & Yoshiki Nishizawa MD, PhD (Professor Emeritus) & 

  2. Division of Nephrololgy Raulston Memorial Research Building, Room 104 Keck School of Medicine, University of Southern California, 2025 Zonal Avenue, 90033, Los Angeles, CA, USA

    Shaul G. Massry MD (Professor of Medicine) (Professor of Medicine)

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Massry, S.G., Smogorzewski, M. (2002). Parathyroid Hormone Toxicity in Chronic Renal Failure. In: Morii, H., Nishizawa, Y., Massry, S.G. (eds) Calcium in Internal Medicine. Springer, London. https://doi.org/10.1007/978-1-4471-0667-8_14

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  • DOI: https://doi.org/10.1007/978-1-4471-0667-8_14

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